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Novel Anticancer Strategies reviews important findings and updates within the cancer therapy field, of great interest to those in academic research studying the development and validation of novel anticancer approaches. The Editor invited preeminent specialists to contribute to original and review articles devoted to key areas of major progress and expectations. Key features: Nanoparticle-based drug delivery in cancer therapy; Extracellular vesicles for anticancer drug delivery; Peptide-based drug conjugates; Cancer stem cells as a valuable target to eradicate tumor relapse; Spheroids in preclinical model for cancer research; and cancer immunotherapy.

Cancer. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors

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This book offers remarkable coverage of liver cancer from etiology to prevention and treatment. It provides an updated and new vision of this major cancer that continues to affect hundreds of thousands of people and remains one of the leading causes of cancer deaths around the world. To ensure the high quality of this book, important insights are included and rigorously discussed in a simple and authentic way. The book includes detailed and updated descriptions of the main causes of liver cancer and also the prevention and treatment of this disease. This book is a relevant source of knowledge, very useful for researchers, medical doctors, medical residents, students, healthcare providers, public health decision makers, and all individuals interested in the prevention of this disease.

Liver Cancer. --- Liver Neoplasms. --- Cancer of the Liver --- Cancer, Hepatocellular --- Hepatic Neoplasms --- Hepatocellular Cancer --- Neoplasms, Hepatic --- Neoplasms, Liver --- Cancer of Liver --- Hepatic Cancer --- Liver Cancer --- Cancer, Hepatic --- Cancer, Liver --- Cancers, Hepatic --- Cancers, Hepatocellular --- Cancers, Liver --- Hepatic Cancers --- Hepatic Neoplasm --- Hepatocellular Cancers --- Liver Cancers --- Liver Neoplasm --- Neoplasm, Hepatic --- Neoplasm, Liver --- Medicine --- Gastrointestinal Oncology --- Oncology --- Health Sciences

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Urologic cancers are an umbrella term for cancers of the prostate, kidney, bladder, penis, and testis. Routine use of advanced imaging modalities for various reasons has increased the incidental detection of some of these cancers at an early stage. Robot-assisted surgery for nephrectomy, prostatectomy, cystectomy, and retroperitoneal lymph node dissection have improved surgical outcomes of localized disease. The introduction of targeted therapies since 2006 has revolutionized the management of metastatic kidney cancer. Despite these advances, the five-year survival of patients with advanced renal cancer is still poor and we need a better understanding of the disease. The book Urologic Cancers brings together an international team of clinicians and basic scientists to provide an up-to-date overview of a wide spectrum of topics that comprise epidemiological, pathological, clinical, and biological aspects of urologic cancers. From the epidemiological spectrum, the most recent information on the epidemiology of testicular cancer and penile cancer are presented. From the clinical spectrum, the characteristics and management of divergent urothelial neoplasms, the role of surgery in the management of testicular and kidney cancer, biopsy approaches for better detection and diagnosis of prostate cancer, the role of family history and germline genetics in prostate cancer disease profiling and screening, and the need for the implementation of quality assurance programs to improve prostate cancer care discussed. The biological aspects of disease mechanisms focus on various emerging molecular pathways and how these can be targeted to develop novel therapeutics. The contents of the book will be of interest to healthcare professionals, basic scientists and clinicians interested in urologic cancers.

urologic cancers --- prostate cancer --- kidney cancer --- testicular cancer --- bladder cancer --- penile cancer

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The process of Epithelial-Mesenchymal-Transition (EMT) is known to result in a phenotype change in cells from a proliferative state to a more invasive state. EMT has been reported to drive the metastatic spread of various cancers and has also been associated with drug resistance to cytotoxics and targeted therapeutics. Recently phenotype switching akin to EMT has been reported in non-epithelial cancers such as metastatic melanoma. This process involves changes in EMT-Transcription Factors (EMT-TFs), suggesting that phenotype-switching may be common to several tumour types. It remains unclear as to whether the presence of both Epilthelial-like and Mesenchymal-like cells are a pre-requisite for phenotype switching within a tumour, how this heterogeneity is regulated, and if alteration of cell phenotype is sufficient to mediate migratory changes, or whether drivers of cell migration result in an associated phenotype switch in cancer cells. Similarly it has yet to be clarified if cells in an altered phenotype can be refractory to drug therapy or whether mediators of drug resistance induce a concurrent phenotypic change. Little is known today about the underlying genetic, epigenetic and transient changes that accompany this phenotypic switch and about the role for the tumor micro-environment in influencing it. Hence this is currently an area of speculation and keen interest in the Oncology field with wide-ranging translational implications. In this Frontiers Research Topic, we discuss our current understanding of these concepts in various cancer types including breast cancer, colorectal cancer and metastatic melanoma. This topic covers how these processes of cellular and phenotypic plasticity are regulated and how they relate to cancer initiation, progression, dormancy, metastases and response to cytotoxics or targeted therapies.

Cancer --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors --- crosstalk --- Immune System --- Phenotype-switching --- plasticity --- Exosomes --- EMT --- Therapy-resistance --- signalling --- heterogeneity

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This book is a comprehensive treatise of the potential risk factors associated with NPC development, the tools employed in the diagnosis and detection of NPC, the concepts behind NPC patients who develop neuro-endocrine abnormalities and ear-related complications after radiotherapy and chemotherapy, the molecular mechanisms leading to NPC carcinogenesis, and the potential therapeutic molecular targets for NPC.

Carcinogenesis. --- Cancer. --- Cancer --- Diagnosisa. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Tumors --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Pathology --- Genetic toxicology --- Pathogenesis --- Oncology