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RNA Viruses: A Practical Approach is wide ranging in scope, from emerging technology such as reverse genetics and retrovirus vectors, to money saving tips - how to make your own silica particles for high efficiency RNA extraction and liposomes for cell transfection! Chapter one covers the fundamentals of investigating RNA virus genome structure at a molecular level. Chapters two and three describe techniques for mutagenesis of RNA genomes and analysis of transcription. Chapter four deals with RNA virus-encoded proteinases, an important aspect of the control of RNA virus gene expression. Chapter five considers retrovirus oncogenesis and chapter six analysis of RNA virus quasispecies. Chapter seven describes systems for investigation of in vitro replication of positive-stranded viruses and chapter eight the packaging of RNA virus genomes. In addition to the technical aspects of reverse genetics and retrovirus vectors, both of the final two chapters also consider ethical aspects of these new technologies.

virologie --- General virology --- RNA (ribonucleic acid) --- RNA viruses --- Research --- Methodology. --- RNA Viruses --- Methodology --- RNA Viruses. --- moleculaire biologie --- mutageniteit --- RNA VIRUSES --- RETROVIRIDAE --- ONCOGENIC VIRUSES --- GENETICS --- ULTRASTRUCTURE

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This book brings together what is currently known in terms of basic research in the field of long noncoding RNAs (lncRNAs) and builds on this to delve more deeply in the specific roles that lncRNAs are playing during inflammation. The book provides readers with basic knowledge on lncRNAs: from understanding the complexity of the transcriptome, conservation, structure and the tools used to investigate these aspects, to how we use this information to study lncRNAs in a specific biological context. The volume covers the emerging roles of lncRNAs in the initial stages of inflammation as well as their roles in specific inflammatory diseases including arthritis, lupus, diabetes and cardiovascular disease. The book also shows the emerging interest in using lncRNAs as a therapeutic target and how this could impact our ability to diagnose and treat inflammatory diseases in the future.

Biomathematics. Biometry. Biostatistics --- Immunology. Immunopathology --- Human genetics --- immunologie --- medische genetica --- bio-informatica --- Non-coding RNA. --- RNA --- Inflamació

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Medical microbiology, virology, parasitology --- Retroviruses --- Virology --- Rétrovirus --- Virologie --- Periodicals --- Research --- Périodiques --- Recherche --- Retroviridae. --- Retroviridae Infections. --- Retroviruses. --- Retrovirology. --- C-type RNA viruses --- Leukemogenic viruses --- Leukoviruses --- Oncornaviruses --- Oncoviruses --- Retroviridae --- RNA tumor viruses --- Infections, Retroviridae --- Infections, Retrovirus --- Retrovirus Infections --- Infection, Retroviridae --- Infection, Retrovirus --- Retroviridae Infection --- Retrovirus Infection --- Leukemogenic Viruses --- Oncovirinae --- Oncoviruses, Type C --- RNA Tumor Viruses --- Type C Oncoviruses --- C Oncovirus, Type --- C Oncoviruses, Type --- Leukemogenic Virus --- Leukovirus --- Oncornavirus --- Oncovirus --- Oncovirus, Type C --- RNA Tumor Virus --- Retrovirus --- Tumor Virus, RNA --- Tumor Viruses, RNA --- Type C Oncovirus --- Virus, Leukemogenic --- Virus, RNA Tumor --- Viruses, Leukemogenic --- Viruses, RNA Tumor --- retrovirus --- human retroviruses --- animal retroviruses --- HIV --- HTLV --- Oncogenic viruses --- RNA viruses --- XMRV Infection --- Xenotropic MuLV-related Virus Infection --- Xenotropic Murine Leukemia Virus-related Virus Infection --- Infection, XMRV --- Infections, XMRV --- XMRV Infections --- Xenotropic MuLV related Virus Infection --- Xenotropic Murine Leukemia Virus related Virus Infection --- Allergy --- allergieën --- Microbiology & Immunology --- hiv --- htlv

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Organic chemistry --- General biochemistry --- Molecular biology --- RNA (ribonucleic acid) --- organische chemie --- biochemie --- genetische manipulatie --- DNA (deoxyribonucleic acid) --- moleculaire biologie

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This book describes the development of novel protein-RNA-binding assays and their applications in a high-throughput manner for the identification of small-molecule modulators of protein-RNA interactions to treat cancer and COVID-19. Modulating protein-RNA interactions with small molecules is expected to provide novel biological insights of the interrelation of diseases with the protein-RNA interactome. The modulations may also be exploited therapeutically. For these reasons, the development of a simple, reliable, and sensitive protein-RNA-binding assay is necessary for high-throughput screening to discover new effective chemical entities capable of acting on diverse protein-RNA interactions. This book discusses the discovery of small-molecule modulators targeting protein-RNA interactions that are potentially valuable to treat cancer and COVID-19 by constructing novel high-throughput screening methods. The results of this dissertation provide valuable insights into the regulation of protein-RNA interactions in chemical biology and drug development.

General biophysics --- Biotechnology --- biofysica --- biotechnologie --- COVID-19 (Disease) --- Cancer --- Neoplasms --- RNA --- COVID-19 --- Proteins --- Molecular aspects. --- therapy. --- genetics.