Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

organohalide respiration --- Microbial reductive dehalogenation --- Dehalococcoides --- electron transport chain --- reductive dehalogenase --- Community composition and function --- bioremediation

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This is a Special Issue on Molecular Electronics which provides an overview of the field and will be useful for both theoreticians and experimentalists. Topics include protein-based electronics, field-induced trans-to-cis isomerisation, phonon thermal conductance, spin-dependent transport, attenuation factors, HOMO-LUMO gap corrections and nanofabrication techniques.

molecular electronics --- self-assembly films --- Langmuir-Blodgett films --- electrografting --- top-contact electrode --- molecular junctions --- attenuation factor --- density functional theory --- graphene --- single molecule junctions --- metal/molecule interface --- energy level alignment --- conductance --- electron transport --- DFT + Σ --- thermoelectricity --- phonon --- thermal conductance --- OPE3 --- anchor groups --- pyridyl --- thiol --- methyl sulphide --- carbodithioate --- spin polarization --- magnetic chain with AAH modulation --- light irradiation --- single-molecule junctions --- STM break-junction --- in-situ isomerisation --- carotenoids --- azurin --- solid-state junction --- biomolecular electronics --- electronic transport --- molecular dynamics --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book, entitled “Mesoporous Metal Oxide Films”, contains an editorial and a collection of ten research articles covering fundamental studies and applications of different metal oxide films. Mesoporous materials have been widely investigated and applied in many technological applications owing to their outstanding structural and physical properties. In this book, important developments in this fast-moving field are presented from various research groups around the world. Different preparation methods and applications of these novel and interesting materials have been reported, and it was demonstrated that mesoporosity has a direct impact on the properties and potential applications of such materials. The potential use of mesoporous metal oxide films and coatings with different morphology and structures is demonstrated in many technological applications, particularly chemical and electrochemical sensors, supercapacitors, solar cells, photoelectrodes, bioceramics, photonic switches, and anticorrosion agents.

SnO2 --- Metglas --- hemin --- H2O2 --- cyclic voltammetry --- magnetoelastic resonance --- sensor --- titanium dioxide --- mesoporous --- thin film --- multi-layered --- photoanode --- semiconductor --- photoelectrochemical water oxidation --- Mn2O3 --- mesoporous materials --- electrochemical characterizations --- electrode --- supercapacitors --- gadolinium oxide --- hydrazine --- p-nitrophenol --- electrochemical sensing --- amperometric --- selective sensor --- nanocrystal --- ZnO --- density of states --- optical and electrical properties --- TiO2 films --- Ag nanoparticles --- optical properties --- spectroelectrochemistry --- surface plasmon --- Fe-doped TiO2 --- hydrothermal --- GCE --- chemical sensor --- amperometry --- dye-sensitized solar cells --- working electrode --- TiO2 --- NiO nanoparticles --- electron transport --- corrosion --- guar gum --- coatings --- electrochemical impedance spectroscopy (EIS) --- SECM --- AFM --- calcium phosphate silicate --- PEG --- bioceramics --- sol-gel preparation --- hard tissue engineering --- metal oxide --- sol-gel --- supercapacitor --- photoelectrode --- dye sensitized solar cell --- NiO

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis and still represents one of the global health threats to mankind. The World Health Organization estimated more than 10 million new cases and reported more than 1.5 million deaths in 2019, thus ranking TB among the main causes of death due to a single pathogen. Standard anti-TB therapy includes four first-line antibiotics that should be administered for at least six months. However, in the case of multi- and extensively drug-resistant TB, second-line medications must be used and these frequently cause severe side effects resulting in poor compliance. Developing new anti-TB drug candidates is therefore of outmost importance. In this Special Issue dedicated to Tuberculosis Drug Discovery and Development, we present the main and latest achievements in the fields of drug and target discovery, host-directed therapy, anti-virulence drugs, and describe the development of two advanced compounds: macozinone and delpazolid. In addition, this Special Issue provides an historical perspective focused on Carlo Forlanini, the inventor of pneumothorax for TB treatment, and includes an overview of the state-of-the-art technologies which are being exploited nowadays in TB drug development. Finally, a summary of TB vaccines that are either approved or undergoing clinical trials concludes the Special Issue.

mycobacteria --- tuberculosis --- multi-drug resistance --- drug discovery --- promiscuous targets --- Mycobacterium tuberculosis --- rifampin --- isoniazid --- mechanisms of resistance --- mutations --- granulomas --- caseum --- cell envelope --- dormancy --- delpazolid --- macozinone --- DprE1 inhibitor --- clinical studies --- discovery --- mode of action --- drug resistance --- toxicity --- target --- energy metabolism --- electron transport chain --- oxidative phosphorylation --- bedaquiline --- Q203 --- MID3 --- pharmacokinetics --- pharmacodynamics --- drug-drug interactions --- in vitro --- in vivo --- drug development --- tuberculosis treatment --- biomarkers --- drug combination --- clinical trial --- BCG --- tuberculosis vaccines --- TBVI --- EDCTP --- IAVI --- CTVD --- host-directed therapy --- anti-virulence compounds --- TB --- post-treatment sequelae --- surgery --- pulmonary rehabilitation --- Carlo Forlanini --- artificial pneumothorax --- n/a --- structure-based drug design --- target-based drug design --- PknB --- PknG --- DNA gyrase --- antibiotic --- mycobacterium --- genomics --- transcriptomics --- proteomics --- metabolomics --- lipidomics --- target identification --- mechanism of action --- antimicrobial drug resistance (AMR) --- target-based screening --- phenotypic screening --- antituberculosis agents --- antimycobacterial --- anti-TB drug pipeline --- privileged targets --- lead generation

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Mitochondria are the powerhouses of cells; however, mitochondrial dysfunction causes energy depletion and cell death in a variety of diseases. Altered oxidative phosphorylation and ion homeostasis are associated with ROS production resulting from the disassembly of respiratory supercomplexes and the disruption of electron transfer chains. In pathological conditions, the dysregulation of mitochondrial homeostasis promotes Ca2+ overload in the matrix and ROS accumulation, which induces the mitochondrial permeability transition pore formation responsible for mitochondrial morphological changes linked to membrane dynamics, and ultimately, cell death. Finally, studies on the impaired mitochondrial bioenergetics in pathology could provide molecular tools to counteract diseases associated with mitochondrial dysfunction.

aging heart --- Bcl-2 family --- mitochondria --- programmed cell death --- fatty acid oxidation --- palmitate --- oleate --- m.3243A&gt --- G mutation --- MT-ATP6 --- m.8909T&gt --- C --- ATP synthase --- nephropathy --- oxidative phosphorylation --- mitochondrial disease --- cardiolipin --- Barth syndrome --- Sengers syndrome --- respiratory chain --- Dilated Cardiomyopathy with Ataxia --- cardiomyopathy --- mammalian complex I --- NADH dehydrogenase --- complex I assembly --- complex I structure --- complex I deficiency --- supernumerary subunits --- electron transport chain --- mitochondrial dysfunction --- Leigh syndrome --- mitochondrial diseases --- yeast --- Saccharomyces cerevisiae --- pet mutants --- pancreatic endocrine cells --- mathematical model --- cellular bioenergetics --- diabetes --- glucagon --- insulin --- exercise --- immune system --- metabolic disease --- COVID-19 --- mitochondrial dynamics --- viral infections --- MAVS --- RIG-I --- MDA5 --- innate immune response --- SARS CoV-2 --- RSV --- influenza --- respiratory supercomplexes --- ROS --- ATP synthase/hydrolase --- mitochondrial permeability transition pore --- cristae --- cellular signaling --- human disease --- mitochondrial dynamic --- cell signaling --- cancer --- respiratory complexes --- oxidative stress --- mitochondrial DNA --- MTCYB mutations --- cytochrome b --- complex III --- aging --- energy metabolism --- entorhinal cortex --- lipoxidation-derived damage --- neurodegeneration --- oxidative damage --- protein import --- respiratory complex assembly --- supercomplexes --- mitochondrial proteostasis --- heart failure --- bioenergetics --- assembly factor --- atypical myopathy --- high-resolution respirometry --- toxicity assays --- cell culture --- equine primary myoblasts --- fibroblasts --- frozen tissue --- leukocytes --- oxygen consumption --- platelets --- respirometry --- skeletal muscle --- n/a