Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The journal publishes, in a strictly practice-oriented manner, scientific and technical contributions, short communications, discussion and position papers as well as other information on all aspects relevant to quality and reliability in chemical measurement. The journal gives special attention to border crossing and transnational problems and to problem solving for practitioners, e.g. accreditation practice and implementation of quality assurance schemes in all laboratories involved in chemical measurement. The journal also aims at providing an information forum for the exchange of views and to foster cooperation between all national and international bodies operating in the fields of accreditation, certification, validation, quality assurance and traceability. The journal will focus on the following topics: Accreditation, Certification, EN-45000 standards, ISO 9000 series, GLP, Quality assurance, Traceability, Measurement uncertainty, Validation, Calibration, Proficiency testing, Reference materials, Definitions, and, Quantities and units.

Chemistry --- Chemical laboratories --- Chemistry, Analytic --- Chimie --- Chimie analytique --- Quality control --- Periodicals. --- Accreditation --- Laboratoires --- Qualité --- Contrôle --- Périodiques --- Agrément --- Chemistry Techniques, Analytical --- Laboratories --- Accreditation. --- Quality Control. --- standards. --- Qualité --- Contrôle --- Agrément --- Business, Economy and Management --- General and Others --- Applied Chemistry --- Business, Economy and Management. --- Applied Chemistry. --- Chemistry. --- Control, Quality --- Controls, Quality --- Quality Controls --- Accreditations --- Analysis, Chemical --- Analytical chemistry --- Chemical analysis --- Chemistry laboratories --- Scientific Experimental Error --- Total Quality Management --- Certification --- Licensure --- Metallurgical analysis --- Mineralogy, Determinative --- Journal --- Periodicals --- E-journals --- Analytic chemistry

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The volumes in the series, Methods in Molecular Biology, are conceived with the biochemist and molecular biologist in mind. The present book, Crystallographic Methods andProtocols, concentrates on the use of X-ray crystallography to solve the detailed three­ dimensional structuresofproteins, nucleic acids, andtheir complexes. Such a structure determination is a major undertaking, demands expertise in a range of skills, and requires considerable resources. The biologically trained worker will probably first become involved when identifying an important scientific problem whose solution would benefit from a full structure. The protein or nucleic acid at issue must be sequenced and prepared to high purity in appropriate quantities, probably by either chemical synthesis for nucleic acids or genetic engineering for proteins. CrystallographicMethods andPro­ tocols aims to give biologically trained workers an insight into the techniques used to crystallize their proteins, obtain the raw X-ray data, and solve and refine the structure. The aim ofa crystal structure determination is to provide infor­ mation that will solve biologically relevant problems; that process normally requires a high resolution structure. The preparationofsuit­ able crystals for a high resolution structure remains the major bottle­ neck in structure determination, and the effective application of appropriate genetic engineering and biochemical techniques in the initial stages pays ahandsome dividend later. The productionofsuit­ able proteins by recombinant methods and the preparationofcrystal­ line derivatives are covered by Skelly and Madden in Chapter 2. Before beginning the data collection required for a high resolution structure, a preliminary characterizationofthe crystals is carried out.

Proteins --- Nucleic acids --- X-ray crystallography --- Protéines --- Acides nucléiques --- Radiocristallographie --- Structure. --- Technique. --- Structure --- Technique --- Nucleic Acids --- Crystallography, X-Ray --- Nucleic Acids, Nucleotides, and Nucleosides --- X-Ray Diffraction --- Amino Acids, Peptides, and Proteins --- Crystallography --- Chemicals and Drugs --- Chemistry Techniques, Analytical --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Animal Biochemistry --- Human Anatomy & Physiology --- Health & Biological Sciences --- 548.73 --- -Proteins --- -X-ray crystallography --- -#WSCH:MACV --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Polynucleotides --- X-ray analysis (Roentgen radiography) of crystals. X-ray investigation of properties. X-ray structure --- 548.73 X-ray analysis (Roentgen radiography) of crystals. X-ray investigation of properties. X-ray structure --- Protéines --- Acides nucléiques --- #WSCH:MACV --- Chemistry. --- Analytical chemistry. --- Analytical Chemistry. --- Analysis, Chemical --- Analytical chemistry --- Chemical analysis --- Metallurgical analysis --- Mineralogy, Determinative --- Physical sciences --- Analytical biochemistry. --- Analytic biochemistry --- Biochemistry --- Chemistry, Analytic --- Bioanalytic chemistry --- Bioanalytical chemistry