Listing 1 - 10 of 109 | << page >> |
Sort by
|
Choose an application
Choose an application
Choose an application
Bioorganic chemistry has expanded rapidly over the past two decades, enriching the disciplines of biology and chemistry and providing important insights into the workings of biological systems at a molecular level. Recently, this growing field has witnessed some very exciting results in applying design and synthesis techniques to many problems in molecular biology. Bridging the gap between chemistry and biology, Topics in Bioorganic and Biological Chemistry: A Series of Books in Support of Teaching and Research will serve the needs of the many graduate students and researchers who work in and study this discipline. This second volume, Bioorganic Chemistry: Peptides and Proteins, provides a broad overview of the topic. It covers the chemical synthesis of peptides and proteins and modern methods for analysis of protein structure and folding, reviews the ways in which proteins function as catalysts, and compares enzymes with antibody catalysts. The text is comprised of 14 chapters, making it ideal for use in a one-semester graduate level special topic course in peptides and proteins. Each chapter begins with an introduction that includes basic principles, a summary of key findings which support current research in the field, and an overview of current research activity. The remainder of each chapter deals in greater detail with a number of recent studies that illustrate the nature of ongoing activity in the field. All chapters have been written by leading researchers, and numerous references are given. Topics in Bioorganic and Biological Chemistry is the first series specifically designed to facilitate the education of graduate students and postdoctoral researchers. The first three volumes in the series, Bioorganic Chemistry: Nucleic Acids, Peptides and Proteins, and Carbohydrates, will also prove helpful to research workers who wish to gain familiarity with specific research topics.
Choose an application
Protein engineering. --- Proteins --- Proteins. --- Analysis.
Choose an application
Proteins --- Biochemistry --- Proteins --- chemistry --- analysis
Choose an application
How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, and structure? Are you tired of scanning review articles, primary papers, and databases to locate that elusive fact? The Academic Press FactsBook Series has established itself as the best source of easily-accessible and accurate facts about protein groups. Described as ""a growing series of excellent manuals"" by Molecular Medicine Today and ""essential works of reference"" by Trends in Biochemical Sciences, the FactsBo
Biomembranes --- General biochemistry --- Carrier proteins. --- Binding proteins --- Transport proteins --- Biological transport --- Protein binding --- Proteins
Choose an application
The chapters in this book thoroughly cover the structure, regulation, and function of matrix metalloproteinases, and provide information on the latest strategies to inhibit enzyme activity. This work will be an indispensable reference tool for investigators with an interest in extracellular matrix biology, matrix turnover, enzymology and biochemistry of proteinases, developmental biology, pathology, and therapeutic interventions.Key Features* Provides state-of-the-art information on a field with broad implications to many areas of biology* Includes detailed coverage of the stru
Metalloproteinases. --- Extracellular matrix proteins. --- Matrix proteins --- Metalloproteases --- Proteins --- Metalloenzymes --- Proteinase --- Extracellular matrix proteins --- Metalloproteinases
Choose an application
Choose an application
The investigation of membrane protein structures classically starts with the detection of transmembrane spans and the determination of their secondary structure. There are many methods devoted to this goal, which are mainly based on the hydrophobicity analysis. The methods developed here thus assume that this result is established. There are intended to determine the topography of transmembrane segments and from that to construct a 3D model. The topography is obtained by considering the mutation distribution of an alignment of homologous sequences together with their mean hydrophobicity. The 3D model is obtained by Monte Carlo energy minimization. To account for the membrane effect on the transmembrane segment assembly, specific restraints, based on a continuous model of the membrane, are added to classical energy terms (van der Waals, Coulomb, and torsion) during minimization. It is shown that this leads to a correct prediction of the conformation (adsorbed or transmembrane) of alpha helices and facilitates the optimization of a transmembrane dimer (glycophorin A). The software has been developed for a computer cluster, that is to say that it runs simultaneously on several computers to solve a single problem. Because the Monte Carlo algorithm is linear, its parallelization on such a system poses several problems for the solution of which various ways have been explored.
Listing 1 - 10 of 109 | << page >> |
Sort by
|