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Immunohistochemistry is the use of specific antibodies to stain particular molecular species in situ. This technique has allowed the identification of many more cell types than could be visualized by classical histology, particularly in the immune system and among the scattered hormone-secreting cells of the endocrine system, and has the potential to improve diagnosis, prognosis and therapeutic options of cancer. This book discusses all aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. It provides step-by-step instructions on the methods of additional molecular technologies such as DNA microarrays, and microdissection, along with the benefits and limitations of each method. The topics of region-specific gene expression, its role in cancer development and the techniques that assist in the understanding of the molecular basis of disease are relevant and necessary in science today. This book is the second volume of three planned, individually-sold volumes on this topic. Like Volume 1, this book fully explains the principles and applications of modern techniques used in the field of molecular genetics. It will be of particular interest to pathologists and molecular pathologists conducting both academic and/or clinical research. * The only book available that translates molecular genetics into cancer diagnosis * The results of each Immunohistochemical and in situ hybridization method are presented in the form of color illustrations * Methods discussed were either developed or refined by expert contributors in their own laboratories.
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The sixth edition of this classic dictionary addresses the need of students and professionals to have access to an up-to-date reference source that not only defines the most recently coined terms, but in many cases also presents important ancillary encyclopedic information. The text has a very broad range, including definitions of strictly genetic words along with a variety of non-genetic terms often encountered in the literature of genetics. There are about 70,000 definitions with tables and drawings to illustrate some. There are also Appendices featuring the classification of living organisms; a chronology of the discoveries and inventions that have led to advances in genetics, cell biology, and the study of evolution; a bibliography of useful books; and a listing of internet sites and databases relevant to genetics and molecular biology.
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