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Nature Methods is a forum for the publication of novel methods and significant improvements to tried-and tested techniques in the life sciences and related areas of chemistry. This monthly publication is aimed at a broad, interdisciplinary audience of academic and industry researchers actively involved in laboratory practice. It provides them with new tools to conduct their research and places a strong emphasis on the immediate practical relevance of the work presented. The journal publishes primary research papers as well as overviews of recent technical and methodological developments, and detailed descriptions of important established methods. We are actively seeking primary methods papers of relevance to the biological and biomedical sciences, including methods grounded in chemistry that have a practical application to the study of biological problems. To enhance the practical relevance of each paper, description of the method must be accompanied by its validation, its application to an important biological question and results illustrating its performance in comparison to available approaches. Articles are selected for publication that present broad interest, thorough assessments of methodological performance and comprehensive technical descriptions that facilitate immediate application.

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