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Oryzias latipes, known as medaka, is a model organism from East Asia. Breeding of this small, egg-laying freshwater teleost fish has long been popular among hobbyists in Japan. Now, as biological science has entered the genome era, the medaka provides significant advantages that make it one of the most valuable vertebrate models: a large collection of spontaneous mutants collected over a century, the presence of highly polymorphic inbred lines established over decades, and a recently completed genome sequence. This book is the first comprehensive monograph to cover a variety of medaka research. It opens with a historical view of medaka, followed by a series of research topics in the four major areas where the medaka is increasingly important: genomics, genetics, and resources; organogenesis and disease models; germ cells, sex determination, and reproduction; and evolution. Readers will find state-of-the-art information on medaka genetics and genomics such as the first isolation of active transposons in vertebrates, the influence of chromatin structure on sequence variation, fine QTL analysis, and versatile mutants as human disease models.

Fish culture. --- Fishes -- Diseases -- Chemotherapy. --- Veterinary pharmacology. --- Oryzias latipes --- Diseases --- Fish as laboratory animals --- Models, Biological --- Embryonic and Fetal Development --- Biological Evolution --- Models, Animal --- Animal Population Groups --- Biology --- Animal Diseases --- Beloniformes --- Animals --- Smegmamorpha --- Biological Science Disciplines --- Morphogenesis --- Biological Processes --- Genetic Processes --- Models, Theoretical --- Reproduction --- Investigative Techniques --- Eukaryota --- Biological Phenomena --- Growth and Development --- Genetic Phenomena --- Reproductive Physiological Processes --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Natural Science Disciplines --- Fishes --- Vertebrates --- Phenomena and Processes --- Reproductive Physiological Phenomena --- Organisms --- Disciplines and Occupations --- Physiological Processes --- Chordata --- Reproductive and Urinary Physiological Phenomena --- Physiological Phenomena --- Disease Models, Animal --- Organogenesis --- Oryzias --- Animals, Laboratory --- Evolution, Molecular --- Genetics --- Zoology --- Health & Biological Sciences --- Zoology - General --- Functional genomics --- Animal models --- Oryzias latipes. --- Aplocheilus latipes --- Haplochilus latipes --- Medaka --- Poecilia latipes --- Life sciences. --- Developmental biology. --- Evolutionary biology. --- Animal genetics. --- Transgenic organisms. --- Animal models in research. --- Life Sciences. --- Animal Models. --- Developmental Biology. --- Evolutionary Biology. --- Transgenics. --- Animal Genetics and Genomics. --- Laboratory animals. --- Evolution (Biology). --- Genetically engineered organisms --- Genetically modified organisms --- GEOs (Genetically engineered organisms) --- GMOs (Genetically modified organisms) --- Genetic engineering --- Animal evolution --- Biological evolution --- Darwinism --- Evolutionary biology --- Evolutionary science --- Origin of species --- Evolution --- Biological fitness --- Homoplasy --- Natural selection --- Phylogeny --- Development (Biology) --- Growth --- Ontogeny --- Animals, Experimental --- Animals in research --- Experimental animals --- Lab animals --- Animal culture --- Laboratory organisms --- Working animals --- Animal experimentation --- Biological models --- Laboratory animals --- Research