Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book presents a comprehensive overview of the roles of ᴅ-amino acids and latest research findings, to reveal their fascinating aspects and to facilitate better understanding of their important roles in physiology and diseases. It also provides useful hints for the development of drugs and functional foods. ᴅ-Amino acids were once called unnatural amino acids and were considered to be insignificant for eukaryotes especially in mammals. However, different ᴅ-amino acids have been revealed to be distributed in various mammalian tissues and to bear important physiological roles. For example, ᴅ-serine is implicated in memory formation and learning, and its abnormal concentration in tissues have been reported in neurological diseases such as schizophrenia and amyotrophic lateral sclerosis. ᴅ-Aspartate is found in a variety of mammalian tissues, particularly in the central nervous system and the genitals. ᴅ-Aspartate facilitates the endocrine secretion of prolactin, inhibits the secretion of melatonin, and plays a peculiar role in the control of reproductive functions in mammals, including the stimulation of testosterone synthesis. Written by the leading scientists in the field, this book is a valuable source of information for researchers in biochemistry, physiology, and neuroscience, as well as in the pharmaceutical and food industries.

General biochemistry --- Biology --- biochemie --- biologie --- geslachtshormonen --- aminozuren

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term “The Glutamate-Glutamine Cycle.” In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book. A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction.

Pathological biochemistry --- Neuropathology --- Human medicine --- medische biochemie --- neurologie --- biochemie --- biomedische wetenschappen --- moleculaire biologie --- enzymen --- aminozuren

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This volume looks at the impact that different cropping systems and tillage have on soil’s biologically active substances. It considers how phytotoxins accumulate and can inhibit the development of cultivated plants. Coverage explores the continuous cropping of rye, crop rotation, no tillage, and conventional tillage. It offers a comprehensive, comparative approach to allelopathic plant-soil interactions. The authors focus on free and bounded biologically active substances such as amino acids, auxins, humic and fulvic acids, transient radicals, and enzymes in light sand soils fertilized with different mineral and organic fertilizers. The chapters address fundamental questions relevant to the environmental challenges we face today and will deal with in the future. The results involve asking basic questions motivated by soil's chemical and biochemical processes. The answers will lead to the improvement of the quality of soil’s organic matter, which, in turn, can lead to increased crop yields. Readers will come to understand the relationship between ecological processes and environmental change on individual levels of biocomplexity as well as on systems in their entirety. The title is ideal for students and teachers for laboratory practical classes. Soil scientists, biochemists, chemists, plant ecophysiologists, “Natural Products” organic chemists, and other environmental scientists and specialists will also find it useful.

Biology --- Pedology --- Agriculture. Animal husbandry. Hunting. Fishery --- Biochemical engineering --- bodemkunde --- bodembescherming --- biochemie --- biologie --- landbouw --- planten --- enzymen --- aminozuren

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book aims to bridge the gap in understanding how protein-tyrosine phosphatases (PTPs), which carry out the reverse reaction of tyrosine phosphorylation, feature in cancer cell biology. The expertly authored chapters will first review the general features of the PTP superfamily, including their overall structure and enzymological properties; use selected examples of individual PTP superfamily members, to illustrate emerging data on the role of PTPs in cancer; and will review the current status of PTP-based drug development efforts. Protein Tyrosine Phosphatases in Cancer,from renowned researchers Benjamin Neel and Nicholas Tonks, is invaluable reading for researchers in oncology, stem cell signaling,and biochemistry. .

Organic spectroscopy --- Histology. Cytology --- General biochemistry --- Oncology. Neoplasms --- Pathological biochemistry --- Human medicine --- biosynthese --- massaspectrometrie --- medische biochemie --- polypeptiden --- stamcellen --- biochemie --- biomedische wetenschappen --- oncologie --- cytologie --- genetische manipulatie --- histologie --- enzymen --- aminozuren

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book is intended to give readers an appreciation of what the future holds, as cutting-edge technologies in synthetic biology and pathway engineering and advanced bioprocessing development pave the way for providing goods and services to benefit humankind that are based on the synergy of two biomasses - i.e. of what a renewable feedstock could yield and an infinite microbial biomass could provide in terms of enzymes and biocatalysts. This 13-chapter book, with an introductory treatise on the guiding principles of green chemistry and engineering metrics, brings together a broad range of research and innovation agendas and perspectives from industries, academia and government laboratories using renewable feedstocks that include macroalgae and lignins. In addition, social-economic aspects and the pillars of competitiveness in regional cluster development are explored as we transition from fossil-fuel-based economies to a circular bioeconomy, with chemurgy and green chemistry being implicit to the innovation movement. The bulk of the book covers specific applications including the bioproduction of amino sugars, dicarboxylic acids, omega-3 fatty acids, starch and fermentable sugars from lignocellulosic materials, and phenolics as building blocks for polymer synthesis. Enzymatic systems for accessing chiral and special-purpose chemicals, as well as the development of specialized enzymes from macroalgae for biofuel and biochemical production are also addressed. Research gaps, hurdles to overcome in various biological processes, and present achievements in the production of biofuels and biochemicals from lignocellulosic materials are discussed. Going beyond the conventional expectation of discussing the production of drop-in chemicals, the book instead emphasizes how the potential of new chemicals and materials can be harnessed through innovative thinking and research. As such, it provides an invaluable reference source for researchers and graduate students interested in Chemurgy and Green Chemistry, as well as for practitioners in the field of industrial biotechnology and biobased industry. Peter C.K. Lau is a Distinguished Professor at Tianjin Institute of Industrial Biotechnology of the Chinese Academy of Sciences, and an Adjunct Professor at the Departments of Chemistry and Microbiology & Immunology, McGill University, Canada.

Chemical thermodynamics --- Chemistry --- Enzymology --- General biophysics --- Relation between energy and economics --- Environmental protection. Environmental technology --- Engineering sciences. Technology --- Production management --- Biotechnology --- Chemical technology --- katalyse --- vetzuren --- biomassa --- energiemanagement (economie) --- thermodynamica --- biologische materialen --- biobrandstoffen --- alternatieve energie --- duurzame energie --- energie-economie --- hernieuwbare energie --- BIT (biochemische ingenieurstechnieken) --- groene chemie --- groene biotechnologie --- bioproducten --- biochemie --- chemie --- industrie --- biotechnologie --- milieuproblematiek --- duurzame ontwikkeling --- ingenieurswetenschappen --- chemische technologie --- polymeren --- enzymen --- aminozuren