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Het fenomeen ‘leven’ is onlosmakelijk verbonden met de aanwezigheid van een aantal bijzondere chemische stoffen: de biomoleculen. Zonder de wisselwerking tussen deze biomoleculen, het hoofdthema van de biochemie, is er geen leven. De wisselwerking is het gevolg van hun structuur, die hun functie dicteert. Het begrijpen van structuur-functierelaties van biomoleculen, en van eiwitten in het bijzonder, is dan ook essentieel om inzicht te krijgen in de complexiteit van verschillende levensnoodzakelijke processen in organismen. Verstoring van biochemische processen leidt tot ziekte. Om via wetenschappelijk onderzoek het ontstaan van ziektes te kunnen ontrafelen en om de werking van de klassieke geneesmiddelen te begrijpen, zijn inzichten in de biochemie van groot belang. Het boek Algemene Biochemie. Functionele bouwstenen van het leven start met een algemene situering en gaat verder met een uitgebreide bespreking van de verschillende bouwstenen van cellen (suikers, nucleotiden, lipiden en eiwitten). De structuurniveaus van eiwitten worden in extenso behandeld en gradueel gekoppeld aan hun functie (en aan de regulatie ervan). Dat culmineert in een hoofdstuk waarin biochemische concepten en mechanismen gekaderd worden in de context van biologische processen of toepassingen: de bloedstolling, de werking van een antibioticum, actinegestuurde celmigratie en vertering. Er wordt aandacht besteed aan ziektebeelden en andere medisch relevante onderwerpen. Dit boek bespreekt de basisaspecten van de biochemie. Daarom is het geschikt als handboek voor studenten uit richtingen die algemene biochemie als verplicht onderdeel in hun curriculum hebben (geneeskunde, tandheelkunde, biomedische wetenschappen, biochemie en biotechnologie, biologie, scheikunde), maar het kan ook worden gebruikt als naslagwerk voor studenten uit de toegepaste biologische wetenschappen, de opleiding tot dierenarts en relevante richtingen uit de hogescholen.
Biochemie --- 577.1 --- General biochemistry --- suiker --- biochemie --- eiwitten --- enzymen --- aminozuren
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Organic spectroscopy --- Histology. Cytology --- General biochemistry --- Molecular biology --- biosynthese --- massaspectrometrie --- polypeptiden --- cytologie --- genetische manipulatie --- histologie --- moleculaire biologie --- aminozuren
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This book summarizes all the important aspects of CRLs (Cullin-RING E3 Ubiquitin Ligases), while providing details of mechanistic specifics that go beyond protein ubiquitination and neddylation. Ubiquitin ligases, including the CRLs, which are activated by neddylation, play an important role in diverse biological processes and are involved in various human diseases, particularly cancer. The book covers various topics, such as CRL structure, biology, genetics, its regulation by neddylation, its pivotal role in human disease, and its potential in drug discovery and targeted therapies. The book appeals to biochemists and biologists working in other fields, and, given the importance of CRLs in all aspects of cell biology and the great promise of targeting these complexes for therapy, is a valuable resource anyone interested in modern biology or medicine.
Organic spectroscopy --- Histology. Cytology --- General biochemistry --- Molecular biology --- biosynthese --- massaspectrometrie --- polypeptiden --- cytologie --- genetische manipulatie --- histologie --- moleculaire biologie --- aminozuren
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Organic spectroscopy --- Organic chemistry --- Chemistry --- Genetics --- Histology. Cytology --- General biochemistry --- Molecular biology --- biosynthese --- massaspectrometrie --- polypeptiden --- organische chemie --- proteomics --- cytologie --- genetische manipulatie --- celprocessen --- genexpressie --- proteïnen --- aminozuren
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Organic spectroscopy --- General biochemistry --- Immunology. Immunopathology --- Allergy --- Pathology of the organs of movement --- biosynthese --- immunologie --- massaspectrometrie --- polypeptiden --- reumatologie --- allergieën --- genetische manipulatie --- aminozuren
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This book presents pioneering findings on the characterization of cellular regulation and function for three recently identified protein posttranslational modifications (PTMs): lysine malonylation (Kmal), glutarylation (Kglu) and crotonylation (Kcr). It addresses three main topics: (i) Detecting Kmal substrates using a chemical reporter, which provides important information regarding the complex cellular networks modulated by Kmal; (ii) Identifying Kglu as a new histone PTM and assessing the direct impact of histone Kglu on chromatin structure and dynamics; and (iii) Revealing Sirt3’s value as a regulating enzyme for histone Kcr dynamics and gene transcription, which opens new avenues for examining the physiological significance of histone Kcr. Taken together, these studies provide information critical to understanding how these protein PTMs are associated with various human diseases, and to identifying therapeutic targets for the dysregulation of these novel protein markers in various human diseases.
Organic spectroscopy --- Organic chemistry --- Chemistry --- Genetics --- Histology. Cytology --- General biochemistry --- Molecular biology --- biosynthese --- massaspectrometrie --- polypeptiden --- organische chemie --- proteomics --- cytologie --- genetische manipulatie --- celprocessen --- genexpressie --- proteïnen --- aminozuren
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This book will address the growing roles of epigenetics in disease pathogenesis, and review the contribution of epigenetic modifications to disease onset and progression. The roles that epigenetics plays in facilitating effects of the environment on allergy and immunologic diseases will be reviewed. The book is divided into three parts – the first is an introduction to epigenetics and the methods that have been developed to study epigenetics, the second addresses epigenetics in allergic diseases and the third part will cover epigenetics in autoimmune diseases. With the rapid expansion of knowledge of how genes are regulated and how this regulation affects disease phenotypes, this book will be attractive to experienced researchers as well as those just launching an epigenetics research program. It will also be of interest to allergist, immunologists, rheumatologists and dermatologist who are engaged in clinical practice as a resource for understanding the basis for personalized and precision medicine. For example, the role that epigenetics plays in the pathogenesis in various allergic and autoimmune disorders and how this determines disease phenotypes will be covered extensively in this book. This book will thus help fill the gap in available resources on epigenetics in allergy and autoimmune diseases.
Organic spectroscopy --- General biochemistry --- Immunology. Immunopathology --- Allergy --- Pathology of the organs of movement --- biosynthese --- immunologie --- massaspectrometrie --- polypeptiden --- reumatologie --- allergieën --- genetische manipulatie --- aminozuren
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