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This book presents recently discovered design principles that govern the structure and behavior of biological networks such as gene circuits, highlighting simple, recurring circuit elements that make up the network. It provides a quantitative theory for which circuits are found in a given environment and a mathematical framework for understanding and even designing biological circuits. The book requires only basic mathematics and includes a review of the necessary background material. It fills a significant need for a textbook and introduction to the concepts, principles, and mathematical tools that will form the basis of future developments in the field. An Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models. •Explains the basic circuitry in transcription regulation, signal transduction, and developmental networks •Includes examples ranging from bacterial chemotaxis through developmental patterning and neuronal circuits to immune recognition •Examines the principle of robustness •Details how constrained evolutionary optimization can be used to understand optimal circuit design •Considers how kinetic proofreading and other mechanisms can minimize errors made in biological information-processing •Includes solved problems after each chapter that detail topics not discussed in the main text Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework which can be used to understand and even design biological circuits. The text avoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles.

Biomathematics. Biometry. Biostatistics --- Mathematical statistics --- Computational biology --- Biological systems --- Bio-informatique --- Systèmes biologiques --- Mathematical models --- Modèles mathématiques --- Systems biology --- Cellule --- cells --- Biologie --- biology --- Développement biologique --- biological development --- Réseau de neurones --- Neural networks --- Mécanisme chimiotactique --- Chemotaxis --- Facteur de transcription --- Transcription factors --- Immunogénétique --- Immunogenetics --- Expression des gènes --- gene expression --- Biosystems --- Systems, Biological --- Biology --- System theory --- Philosophy --- Computational biology. --- Systems biology. --- Basic Sciences. Biology --- Mathematical models. --- Biosystematics --- Biosystematics. --- Systèmes biologiques --- Modèles mathématiques --- Bioinformatics --- Molecular biology --- Biological systems - Mathematical models