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This book provides essential insights into improving protein folding/stability, which is a result of the balance between the intra-molecular interactions of protein functional groups and their interactions with the solvent environment. Even a subtle change in the composition of the solvent environment will alter the fidelity of the protein folding process, and hostile environmental stresses represent one of the basic causes of challenges in protein folding or misfolding. Among the strategies employed in a wide range of species and cell types to circumvent the hostile environmental conditions is the elaboration of small organic molecules called osmolytes, and recent advances have revealed that certain specific osmolytes might be key biomarkers of cancer, infectious diseases and are useful in heterologous protein expression and vaccine flocculation. As such a large pool of data has been collected regarding their potential for therapeutic intervention in neurodegenerative diseases and other metabolic disorders caused by protein aggregation or proteiostasis failure.

Medicine. --- Cancer research. --- Biomedical engineering. --- Biochemistry. --- Plant biochemistry. --- Proteins. --- Cell physiology. --- Biomedicine. --- Biomedical Engineering/Biotechnology. --- Cell Physiology. --- Protein-Ligand Interactions. --- Cancer Research. --- Animal Biochemistry. --- Plant Biochemistry. --- Molecular chaperones. --- Chaperone proteins --- Chaperones, Molecular --- Chaperonins --- Proteins --- RNA-ligand interactions. --- Oncology. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Tumors --- Cell function --- Cytology --- Physiology --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Composition --- Proteins . --- Phytochemistry --- Plant biochemistry --- Plant chemistry --- Biochemistry --- Botany --- Phytochemicals --- Plant biochemical genetics --- Cancer research --- Proteids --- Biomolecules --- Polypeptides --- Proteomics

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This book provides essential insights into improving protein folding/stability, which is a result of the balance between the intra-molecular interactions of protein functional groups and their interactions with the solvent environment. Even a subtle change in the composition of the solvent environment will alter the fidelity of the protein folding process, and hostile environmental stresses represent one of the basic causes of challenges in protein folding or misfolding. Among the strategies employed in a wide range of species and cell types to circumvent the hostile environmental conditions is the elaboration of small organic molecules called osmolytes, and recent advances have revealed that certain specific osmolytes might be key biomarkers of cancer, infectious diseases and are useful in heterologous protein expression and vaccine flocculation. As such a large pool of data has been collected regarding their potential for therapeutic intervention in neurodegenerative diseases and other metabolic disorders caused by protein aggregation or proteiostasis failure.

Chemical structure --- Genetics --- Histology. Cytology --- General biochemistry --- Animal biochemistry --- Human biochemistry --- Pharmacology. Therapy --- Oncology. Neoplasms --- Biochemical engineering --- Biotechnology --- RNA (ribonucleic acid) --- moleculaire structuur --- klinische chemie --- medische biochemie --- protein-ligand binding constant --- protein-engineering --- farmacologie --- biochemie --- biomedische wetenschappen --- oncologie --- besmettelijke ziekten --- biotechnologie --- cytologie --- vaccinatie --- eiwitten --- planten --- moleculaire biologie

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Proteostasis is central to the development of various human diseases caused due to excessive protein misfolding and the disregulation of the protein quality control system. In this book, respected researchers from many leading institutions contribute their insights on proteostasis maintenance. The coverage mainly focuses on the basics of maintaining proteostasis, the consequences of proteostatic system failure, and how chaperone systems constantly maintain proteostasis. In addition, the book presents in detail different treatment strategies for diseases caused by proteostatic system failure, as well as the inhibition of proteostatic failure using small molecule compounds. It examines advances in the modulation of proteopathies, providing a comprehensive source of key mechanistic insights on these diseases. As such, the book offers a valuable resource for beginners and more experienced investigators alike who are looking for detailed and reliable information on protein homeostasis, the diseases that can develop due to related imbalances, and the essential role of molecular and chemical chaperones.

Biochemistry --- Chemistry --- Physical Sciences & Mathematics --- Proteins. --- Proteomics. --- Proteids --- Life sciences. --- Life Sciences. --- Protein Science. --- Protein Structure. --- Protein-Ligand Interactions. --- Molecular biology --- Proteins --- Biomolecules --- Polypeptides --- Proteomics --- Biochemistry. --- RNA-ligand interactions. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Composition --- Proteins .