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This volume of the Subcellular Biochemistry series is devoted to the aggregation and fibrillogenesis of the amyloid-forming peptides and proteins, including emphasis on oligomer formation as well as fibril formation. The diverse topics included here are presented within 22 chapters, covering many of the relevant topics from both a basic science and clinical perspective. The authorship of these chapters is thoroughly international, with authoritative contributions from active researchers. Fundamental structural and cellular studies using many different technical approaches are presented, leading through to clinical and therapeutic aspects of the amyloid diseases, considered from both pharmaceutical and natural product view points. It is hoped that this book will be of use to both biomedical scientists and clinicians wishing to keep abreast of this rapidly advancing field, of direct importance to the understanding of cerebral neurodegenerative disease and systemic amyloid disease.

Amyloid. --- Amyloidosis -- Diagnosis. --- Amyloidosis -- Treatment. --- Amyloidosis. --- Amyloid beta-protein --- Aggregation (Chemistry) --- Amyloidosis --- Proteins --- Proteostasis Deficiencies --- Biophysical Processes --- Multiprotein Complexes --- Pathological Conditions, Anatomical --- Biochemical Processes --- Cell Movement --- Physical Processes --- Metabolic Diseases --- Cell Physiological Processes --- Amino Acids, Peptides, and Proteins --- Macromolecular Substances --- Biochemical Phenomena --- Chemical Processes --- Biophysical Phenomena --- Pathological Conditions, Signs and Symptoms --- Nutritional and Metabolic Diseases --- Diseases --- Chemical Phenomena --- Physical Phenomena --- Chemicals and Drugs --- Cell Physiological Phenomena --- Phenomena and Processes --- Protein Folding --- Plaque, Amyloid --- Amyloid --- Cell Aggregation --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Metabolism --- Disorders. --- Protein metabolism disorders --- Amyloid degeneration --- Medicine. --- Entomology. --- Biomedicine. --- Biomedicine general. --- Medicine/Public Health, general. --- Lymphoproliferative disorders --- Disorders --- Insects --- Zoology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce --- Biomedicine, general. --- Medicine --- Biology --- Invertebrates. --- Medical sciences. --- Biomedical Research. --- Invertebrate Zoology. --- Health Sciences. --- Research. --- Invertebrata --- Animals --- Biological research --- Biomedical research --- Basic medical sciences --- Basic sciences, Medical --- Biomedical sciences --- Health sciences --- Preclinical sciences --- Sciences, Medical

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A volume within the Subcellular Biochemistry series is an appropriate setting for the first multi-author book devoted to the new family of antioxidant and cell signalling proteins, the peroxiredoxins. Within the antioxidant and cell signalling fields, even the existence of the peroxiredoxins has yet to be appreciated by many; with this book we aim to rectify this situation. We have tried to select diverse chapter topics to cover relevant aspects of the subject and to persuade knowledgeable authors to contribute a manuscript. As almost inevitable, a few authors let us down by failing to respond, others could not submit a manuscript in time for personal reasons. These unfortunately were two of the pioneers, Earl Stadtman and Sue Goo Rhee, but we appreciate that they communicated a lot of details that helped us to reconstruct the early phase of peroxiredoxin enzymology. We have thus compiled a book that competently covers the peroxiredoxin field from its beginnings through to currently relevant topics. In the introductory Chapter 1 we provide a short historical survey of the subject, based upon the early structural and enzymic studies on peroxiredoxins, and then lead into some of our current personal interests, such as the likely continuing contribution of transmission electron microscopy (TEM) for the study of high molecular mass peroxiredoxin complexes and the association of peroxiredoxins with other proteins, and the targeting of drugs against microbial peroxiredoxins, as future therapeutic approaches.

Proteins. --- Antioxidants. --- Oxidation-reduction reaction. --- Electron transfer reaction --- Oxido-reduction --- Redox reaction --- Chemical reactions --- Chemical inhibitors --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Medical parasitology. --- Biochemistry. --- Cytology. --- Microbiology. --- Bacteriology. --- Parasitology. --- Biochemistry, general. --- Cell Biology. --- Microbiology --- Microbial biology --- Biology --- Microorganisms --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Human beings --- Human parasitology --- Parasitology --- Parasitic diseases --- Composition --- Parasites --- Cell biology.

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The Subcellular Biochemistry series has recently embarked upon an almost encyclopaedic coverage of topics relating to the structure and function of macromolecular complexes (Volumes 82, 83 and 87). The present multi-author text covers numerous aspects of current research into molecular virology, with emphasis upon viral protein and nucleoprotein structure and function. Structural data from cryo-electron microscopy and X-ray crystallography is displayed throughout the book. The 17 chapters in the book cover diverse interesting topics, all currently under investigation, contributed by authors who are active actively involved in present-day research. Whilst structural aspects predominate, there is much consideration of the structure-function relationship. In addition, the book correlates with and extends from Volume 68 of the series “Structure and Physics of Viruses: An Integrated Textbook”. This book is directed primarily at professionals that work in the broad field of Structural Biology and will be of particular interest to Structural Virologists. The editors, David Bhella and Robin Harris, have much experience in virology and protein structure, respectively. Dr Bhella is Director of the Scottish Macromolecular Imaging Centre. Professor Robin Harris is the long-standing Series Editor of the Subcellular Biochemistry series. He has edited and contributed to several books in the series.

Viral proteins. --- Nucleoproteins. --- Molecular virology. --- Life sciences. --- Proteins. --- Life Sciences. --- Protein Science. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Biosciences --- Sciences, Life --- Science --- Nucleoproteins --- Molecular virology --- Viruses --- Molecular microbiology --- Virology --- Ribonucleoproteins --- Nucleic acids --- Proteins --- Microbial proteins --- Molecular aspects --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition --- Proteins .

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General biochemistry --- Neuropathology --- neurologie --- biochemie --- moleculaire biologie

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The Subcellular Biochemistry series has recently embarked upon an almost encyclopaedic coverage of topics relating to the structure and function of macromolecular complexes (Volumes 82, 83 and 87). The present multi-author text covers numerous aspects of current research into molecular virology, with emphasis upon viral protein and nucleoprotein structure and function. Structural data from cryo-electron microscopy and X-ray crystallography is displayed throughout the book. The 17 chapters in the book cover diverse interesting topics, all currently under investigation, contributed by authors who are active actively involved in present-day research. Whilst structural aspects predominate, there is much consideration of the structure-function relationship. In addition, the book correlates with and extends from Volume 68 of the series “Structure and Physics of Viruses: An Integrated Textbook”. This book is directed primarily at professionals that work in the broad field of Structural Biology and will be of particular interest to Structural Virologists. The editors, David Bhella and Robin Harris, have much experience in virology and protein structure, respectively. Dr Bhella is Director of the Scottish Macromolecular Imaging Centre. Professor Robin Harris is the long-standing Series Editor of the Subcellular Biochemistry series. He has edited and contributed to several books in the series.

Chemical structure --- General biochemistry --- protein-engineering --- biochemie --- eiwitten --- moleculaire biologie