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General embryology. Developmental biology --- Cell Aging. --- Cell Survival. --- Cells --- Cellules --- Aging. --- Vieillissement --- Aging --- Cell Viability --- Cell Viabilities --- Survival, Cell --- Viabilities, Cell --- Viability, Cell --- Cell Growth Processes --- Aging, Biological --- Biological Aging --- Senescence --- Mutation Accumulation --- Cellular Senescence. --- Cell Survival --- Cells - Aging

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Stresses which arise in bioreactors can influence process performance considerably. Recent molecular biological investigations indicate that stress caused by fluid dynamical effects and extreme values of process variables and toxic substances cause similar responses in the cells. These molecular fundamentals, as well as quantitative evaluation of fluid dynamical stresses and, their effects on microorganisms, animal and plant cells and proteins are treated in this volume.

Chemistry --- Biotechnology --- Chemical engineering --- Microbiology --- Cellules--Physiologie --- Cellules--Croissance--Régulation --- Régulation cellulaire --- Cell Physiological Phenomena --- Cell Division --- Cells --- Cell Proliferation --- Phenomena and Processes --- Genetic Processes --- Cell Cycle --- Anatomy --- Genetic Phenomena --- Cell Physiological Processes --- Cell Growth Processes --- Growth --- Growth and Development --- Physiological Processes --- Physiological Phenomena --- Cell physiology. --- Cellular control mechanisms. --- Regulation. --- Biotechnology. --- Chemical engineering. --- Microbiology. --- Industrial Chemistry/Chemical Engineering. --- Microbial biology --- Biology --- Microorganisms --- Chemistry, Industrial --- Engineering, Chemical --- Industrial chemistry --- Engineering --- Chemistry, Technical --- Metallurgy --- Genetic engineering --- Cell Division. --- Stress (microbial)

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This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods providing a a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as ""yet another"" general hallmark of canc

Biochemistry -- Analysis. --- Biochemistry -- Technique. --- Biotechnology -- Methodology. --- Cells -- Laboratory manuals. --- Enzymes -- Analysis. --- Enzymes. --- Diseases --- Metabolism --- Cell Physiological Processes --- Drug Therapy --- Growth --- Metabolic Phenomena --- Therapeutics --- Cell Physiological Phenomena --- Growth and Development --- Phenomena and Processes --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Physiological Processes --- Physiological Phenomena --- Molecular Targeted Therapy --- Cell Growth Processes --- Neoplasms --- Metabolic Networks and Pathways --- Cancer --- Cell metabolism --- Cancer cells --- Cytopathology --- Research --- Methodology. --- Biochemistry. --- Cancer. --- Cancers --- Carcinoma --- Malignancy (Cancer) --- Malignant tumors --- Biocatalysts --- Ferments --- Soluble ferments --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Composition --- Tumors --- Catalysts --- Proteins --- Enzymology --- Biology --- Chemistry --- Medical sciences

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Stem Cell Biology in Health and Disease presents an up-to-date overview about the dual role of stem cells in health and disease. The Editors have drawn together an international team of experts providing chapters which, in this fully-illustrated volume, discuss: - the controversial debate on the great expectations concerning stem cell based regeneration therapies raised by the pluripotency of various stem cells. - the advantages and concerns about embryonic stem cells (ES cells), induced pluripotent stem cells (iPS cells) and adult stem cells, such as bone marrow-derived stem cells (BMDCs). - the type of stem cells, which has become of interest in the past decade, namely so-called cancer stem cells (CSCs). CSCs are now in the focus of cancer research since the eradication of tumour initiating cells would raise the changes of definitely cure cancer. Professor Dittmar and Professor Zänker have edited a must-read book for researchers and professionals working in the field of regenerative medicine and/or cancer.

Adipose tissues. --- Stem cells -- Research. --- Stem cells. --- Stem cells --- Cancer cells --- Neoplastic Stem Cells --- Stem Cell Transplantation --- Stem Cells --- Cell Growth Processes --- Cell Transplantation --- Cells --- Cell Physiological Processes --- Growth --- Cell Physiological Phenomena --- Anatomy --- Transplantation --- Growth and Development --- Surgical Procedures, Operative --- Phenomena and Processes --- Physiological Processes --- Physiological Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Cytology --- Oncology --- Medicine --- Biology --- Health & Biological Sciences --- Research --- Regulation --- Embryonic stem cells. --- Research. --- Embryonal stem cells --- Medicine. --- Cancer research. --- Immunology. --- Oncology. --- Surgical transplantation. --- Biomedicine. --- Cancer Research. --- Stem Cells. --- Transplant Surgery. --- Oncology  . --- Transplantation of organs, tissu. --- Immunobiology --- Life sciences --- Serology --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Tumors --- Medical transplantation --- Organ transplantation --- Organ transplants --- Organs (Anatomy) --- Surgical transplantation --- Tissue transplantation --- Tissues --- Transplant surgery --- Transplantation surgery --- Transplants, Organ --- Surgery --- Preservation of organs, tissues, etc. --- Procurement of organs, tissues, etc. --- Cancer research

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The two greatest medical fears of the aging population are cancer and Alzheimer’s disease. Despite dramatic advances in understanding the molecular etiology of these disorders, therapeutic options for many patients with advanced disease have changed little and outcomes remain dismal. Paradoxically, recent findings suggest that some of the same molecules and biochemical processes underlying cancer may also participate in neurodegeneration. Therefore, it would be very useful to bring together experts from the fields of cancer research and neurodegeneration for discussions of the latest advances and ideas, with a particular emphasis on areas of overlap, to stimulate transdisciplinary interactions with the hope of accelerating progress. Cancer arises as a consequence of a breakdown in the genetic and epigenetic processes governing cell proliferation and cell death. Alterations in several classes of signaling molecules, both oncogenes and tumor suppressor genes, lead to uncontrolled cell growth. Over the past two decades, details of the intricate signaling pathways, from cell surface receptors through protein kinase cascades, transcription factors and modulators of chromatin, as well as the DNA damage response pathways linked to cell cycle control that guard the genome, have been uncovered. In some instances, key regulatory proteins have provided novel targets for development of small molecule inhibitors that are currently being tested in the clinic. The development of the nervous system relies on many of the signaling pathways and growth control processes that go awry in cancer. However, in mature neurons, the very same signaling proteins participate in transduction cascades linking short-term stimuli, elicited by synaptic stimulation, to long-term alterations in neuronal circuits through the regulation of gene expression and chromatin structure. These long-term adaptive modifications lead to changes in synaptic structure and function that contribute to learning and memory. The persistence of growth regulatory molecules in postmitotic neurons provides an opportunity for their contribution to pathophysiological processes resulting in neuronal loss. Recently, evidence has accumulated suggesting an association of cell cycle proteins and signal transduction proteins with neurodegeneration. Indeed, inhibitors of histone deacetylation have shown promise both as anti-cancer agents and in the prevention of neuronal loss.

Cancer. --- Central Nervous System -- Drug effects. --- Central Nervous System -- Metabolism. --- Hormones -- Metabolism. --- Hormones -- Physiology. --- Neoplasms. --- Nervous system -- Degeneration -- Endocrine aspects. --- Dementia --- Tauopathies --- Physiological Processes --- Cell Growth Processes --- Pathologic Processes --- Diseases --- Cell Physiological Processes --- Physiological Phenomena --- Cell Physiological Phenomena --- Pathological Conditions, Signs and Symptoms --- Brain Diseases --- Delirium, Dementia, Amnestic, Cognitive Disorders --- Neurodegenerative Diseases --- Growth --- Central Nervous System Diseases --- Nervous System Diseases --- Mental Disorders --- Growth and Development --- Phenomena and Processes --- Psychiatry and Psychology --- Alzheimer Disease --- Nerve Degeneration --- Cell Proliferation --- Homeostasis --- Cell Death --- Neoplasms --- Medicine --- Health & Biological Sciences --- Neurology --- Nervous system --- Alzheimer's disease. --- Degeneration. --- Medicine. --- Cancer research. --- Neurosciences. --- Biomedicine. --- Cancer Research. --- Alzheimer disease --- Alzheimer's dementia --- Basal ganglia --- Presenile dementia --- Senile dementia --- Degeneration, Nerve --- Nerve degeneration --- Nervous system degeneration --- Neurodegenerative disease --- Neurodegenerative diseases --- Neurodegenerative disorders --- Neuron degeneration --- Nissl degeneration --- Retrograde degeneration --- Wallerian degeneration --- Degeneration (Pathology) --- Degeneration and regeneration --- Oncology. --- Tumors --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Cancer research