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A long time has passed since the war act on Cancer declared by former USA president Nixon, almost half a century ago. Today, after so many years of feverish research and uncountable efforts worldwide, the end of the war appears far as ever, whereas the fight is leading researchers to newer and newer battlefronts while frontiers in bioscience are continuously being surpassed. In this scenario, “The Selfish Cell” is a script record of the most important strategic points gathered during these years of war, with the goal to provide solid ground onto which to step ahead for future assaults against this terrible disease. At the same time, it is an attempt to shift the debate on cancer toward a more peaceful and possibly productive semantic terrain, where to reflect with the aid of superior wisdom to finally get out of that terrible chaos of fight and death dominating our days. In this perspective, “The selfish cell” becomes an occasion for reflecting the limits of our human selfishness and their consequences on both our social and natural environment.

Cancer cells. --- Cells --- Evolution. --- Cell evolution --- Cellular evolution --- Evolution (Biology) --- Pathology, Cellular --- Oncology. --- Oncology  . --- Molecular ecology. --- Ethics. --- Evolution (Biology). --- Cancer Research. --- Molecular Ecology. --- Evolutionary Biology. --- Animal evolution --- Animals --- Biological evolution --- Darwinism --- Evolutionary biology --- Evolutionary science --- Origin of species --- Biology --- Evolution --- Biological fitness --- Homoplasy --- Natural selection --- Phylogeny --- Deontology --- Ethics, Primitive --- Ethology --- Moral philosophy --- Morality --- Morals --- Philosophy, Moral --- Science, Moral --- Philosophy --- Values --- Ecology --- Molecular biology --- Tumors --- Molecular aspects --- Cancer research. --- Evolutionary biology. --- Cancer research

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Histology. Cytology --- Molecular biology --- Cells --- Cytology --- Cytologie --- Biologie moléculaire --- Molecular Biology --- Cytology. --- Molecular biology. --- Cells. --- Molecular Biology. --- Biochemical Genetics --- Biology, Molecular --- Genetics, Biochemical --- Genetics, Molecular --- Molecular Genetics --- Biochemical Genetic --- Genetic, Biochemical --- Genetic, Molecular --- Molecular Genetic --- Cell --- Cell Biology --- #GBIB:CBMER --- celleer --- cytologie --- moleculaire biologie --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cell biology --- Cellular biology --- Biology --- Cytologists --- Basic Sciences. Molecular Biology --- Molecular Biology (General) --- Genetic Phenomena --- Molecular Biology (General). --- Biologie moléculaire --- cellular biology --- Cellular biochemistry --- Cell evolution --- Cancer induction(DNA Alteration)

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The evolution of multicellularity raises questions regarding genomic and developmental commonalities and discordances, selective advantages and disadvantages, physical determinants of development, and the origins of morphological novelties. It also represents a change in the definition of individuality, because a new organism emerges from interactions among single cells. This volume considers these and other questions, with contributions that explore the origins and consequences of the evolution of multicellularity, addressing a range of topics, organisms, and experimental protocols.Each section focuses on selected topics or particular lineages that present a significant insight or challenge. The contributors consider the fossil record of the paleontological circumstances in which animal multicellularity evolved; cooptation, recurrent patterns, modularity, and plausible pathways for multicellular evolution in plants ; theoretical approaches to the amoebozoa and fungi (cellular slime molds having long provided a robust model system for exploring the evolution of multicellularity), plants, and animals; genomic toolkits of metazoan multicellularity ; and philosophical aspects of the meaning of individuality in light of multicellular evolution.

Evolution (Biology) --- Cells --- Self-organizing systems. --- Learning systems (Automatic control) --- Self-optimizing systems --- Cybernetics --- Intellect --- Learning ability --- Synergetics --- Cell evolution --- Cellular evolution --- Animal evolution --- Animals --- Biological evolution --- Darwinism --- Evolutionary biology --- Evolutionary science --- Origin of species --- Biology --- Evolution --- Biological fitness --- Homoplasy --- Natural selection --- Phylogeny --- Evolution. --- Paleobotany. --- Paleoecology. --- Plants --- BIOMEDICAL SCIENCES/Evolution --- BIOMEDICAL SCIENCES/General --- Plant evolution --- Palaeoecology --- Ecology --- Paleobiology --- Fossil botany --- Palaeobotany --- Botany --- Paleontology --- Multicellularity. --- Self-organizing systems --- Developmental Biology --- Morphogenesis --- Cell interaction --- Growth and Development. --- Eukaryota. --- Physiological Phenomena. --- Genetic Phenomena. --- Biological Phenomena. --- Biological Science Disciplines. --- Organisms --- Cell Physiological Phenomena. --- Natural Science Disciplines. --- Biophysics --- Paleobotany --- Geology --- Molecular evolution. --- Biocomplexity. --- Growth and Development --- Eukaryota --- Physiological Phenomena --- Genetic Phenomena --- Biological Science Disciplines --- Cell Physiological Phenomena --- Natural Science Disciplines

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The enormous recent success of molecular developmental biology has yielded a vast amount of new information on the details of development. So much so that we risk losing sight of the underlying principles that apply to all development. To cut through this thicket, John Tyler Bonner ponders a moment in evolution when development was at its most basic--the moment when signaling between cells began. Although multicellularity arose numerous times, most of those events happened many millions of years ago. Many of the details of development that we see today, even in simple organisms, accrued over a long evolutionary timeline, and the initial events are obscured. The relatively uncomplicated and easy-to-grow cellular slime molds offer a unique opportunity to analyze development at a primitive stage and perhaps gain insight into how early multicellular development might have started. Through slime molds, Bonner seeks a picture of the first elements of communication between cells. He asks what we have learned by looking at their developmental biology, including recent advances in our molecular understanding of the process. He then asks what is the most elementary way that polarity and pattern formation can be achieved. To find the answer, he uses models, including mathematical ones, to generate insights into how cell-to-cell cooperation might have originated. Students and scholars in the blossoming field of the evolution of development, as well as evolutionary biologists generally, will be interested in what Bonner has to say about the origins of multicellular development--and thus of the astounding biological complexity we now observe--and how best to study it.

Cell interaction. --- Cells -- Evolution. --- Developmental biology. --- Developmental cytology. --- Cell Differentiation --- Signal Transduction --- Biological Evolution --- Genetic Processes --- Cell Physiological Processes --- Biochemical Processes --- Biological Processes --- Biochemical Phenomena --- Biological Phenomena --- Cell Physiological Phenomena --- Chemical Processes --- Genetic Phenomena --- Phenomena and Processes --- Chemical Phenomena --- Biophysics --- Biology --- Health & Biological Sciences --- Biologic Phenomena --- Biological Phenomenon --- Biological Process --- Phenomena, Biological --- Phenomena, Biologic --- Phenomenon, Biological --- Process, Biological --- Processes, Biological --- Biochemical Concepts --- Biochemical Phenomenon --- Biochemical Process --- Phenomena, Biochemical --- Biochemical Concept --- Concept, Biochemical --- Concepts, Biochemical --- Phenomenon, Biochemical --- Process, Biochemical --- Processes, Biochemical --- Molecular Biology --- Cell Physiological Phenomenon --- Cell Physiological Process --- Physiology, Cell --- Cell Physiology --- Phenomena, Cell Physiological --- Phenomenon, Cell Physiological --- Physiological Process, Cell --- Physiological Processes, Cell --- Process, Cell Physiological --- Processes, Cell Physiological --- Cells --- Genetic Concepts --- Genetic Phenomenon --- Genetic Process --- Concept, Genetic --- Concepts, Genetic --- Genetic Concept --- Phenomena, Genetic --- Phenomenon, Genetic --- Process, Genetic --- Processes, Genetic --- Evolution, Biological --- Sociobiology --- Receptor Mediated Signal Transduction --- Signal Transduction Pathways --- Signal Transduction Systems --- Cell Signaling --- Receptor-Mediated Signal Transduction --- Signal Pathways --- Pathway, Signal --- Pathway, Signal Transduction --- Pathways, Signal --- Pathways, Signal Transduction --- Receptor-Mediated Signal Transductions --- Signal Pathway --- Signal Transduction Pathway --- Signal Transduction System --- Signal Transduction, Receptor-Mediated --- Signal Transductions --- Signal Transductions, Receptor-Mediated --- System, Signal Transduction --- Systems, Signal Transduction --- Transduction, Signal --- Transductions, Signal --- Cell Communication --- Receptor-CD3 Complex, Antigen, T-Cell --- Receptor Cross-Talk --- Feedback, Physiological --- Gasotransmitters --- Differentiation, Cell --- Cell Differentiations --- Differentiations, Cell --- Embryo, Mammalian --- Gene Expression Regulation --- Cell Lineage --- Chemical Phenomenon --- Chemical Process --- Physical Chemistry Phenomena --- Physical Chemistry Process --- Physicochemical Phenomenon --- Physicochemical Process --- Chemical Concepts --- Physical Chemistry Concepts --- Physical Chemistry Processes --- Physicochemical Concepts --- Physicochemical Phenomena --- Physicochemical Processes --- Chemical Concept --- Chemistry Process, Physical --- Chemistry Processes, Physical --- Concept, Chemical --- Concept, Physical Chemistry --- Concept, Physicochemical --- Concepts, Chemical --- Concepts, Physical Chemistry --- Concepts, Physicochemical --- Phenomena, Chemical --- Phenomena, Physical Chemistry --- Phenomena, Physicochemical --- Phenomenon, Chemical --- Phenomenon, Physicochemical --- Physical Chemistry Concept --- Physicochemical Concept --- Process, Chemical --- Process, Physical Chemistry --- Process, Physicochemical --- Processes, Chemical --- Processes, Physical Chemistry --- Processes, Physicochemical --- physiology --- Cell interaction --- Developmental biology --- Developmental cytology --- 57.017.22 --- 575.853 --- Cell evolution --- Cellular evolution --- Evolution (Biology) --- Evolution --- 575.853 The cell and subcellular structure --- The cell and subcellular structure --- 57.017.22 Origin. Formation. Precursors --- Origin. Formation. Precursors --- Cytology --- Development (Biology) --- Growth --- Ontogeny --- Cell-cell interaction --- Cell communication --- Cellular communication (Biology) --- Cellular interaction --- Intercellular communication --- Cellular control mechanisms --- Signal Transduction. --- Biological Evolution. --- Cell Differentiation. --- Origin of Life. --- Genesis of Life --- Life Geneses --- Life Genesis --- Life Origin --- Life Origins --- Organelle Biogenesis --- Prebiotic Chemical Evolution --- Chemical Evolution, Prebiotic --- Evolution, Prebiotic Chemical --- Prebiotic Chemical Evolutions