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Human biochemistry --- massaspectrometrie --- medische biochemie --- biochemie
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Spectrometric and optical chemical analysis --- Chemistry --- massaspectrometrie
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Mass spectrometry (MS) along with its hyphenated techniques is capable of high throughput, sensitivity, accuracy and selectivity for the analysis of structure and composition of almost any product. Like in electrophoresis, MS separates mo- cules based on the mass-to-charge ratio. In case of gel electrophoresis (SDS- PAGE), a well-known and efficient bioanalytical technique, proteins bear negative charges but have the same charge density, so proteins are separated according to their size. Similarly, in case of MS analysis, proteins carry the same charge, and are separated by their molecular weight. Unlike SDS-PAGE, however, modern ultra high resolution MS discerns very small mass differences and can resolve and completely identify in a single experiment species of the same nominal mass in complex biological mixtures. Consequently, MS can be used for the structural characterization, identification and sensitive detection of mixtures of biomolecules or for assessing the quality of isolated proteins (purity, integrity, or post-translational modifications, for example), carbohydrates, nucleic acids, drugs, metabolites, pollutants etc. In the post-genome era, MS is continuously developing as one of the most re- able analytical method for elucidating the structure of molecules originating from various biological matrices. The potential of MS for high-sensitive structural a- lyses became unsurpassable after the introduction of electrospray (ESI) and matrix assisted laser/desorption ionization (MALDI) methods, on one hand, and the pos- bility to deduce in detail unknown biopolymer structures by highly accurate mo- cular mass measurement followed by sequencing using dissociation techniques based on multiple stage MS, on the other.
Analytical chemistry --- General biochemistry --- Biology --- massaspectrometrie --- analytische chemie --- biochemie --- biologie
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Analytical chemistry --- General biochemistry --- Biology --- massaspectrometrie --- analytische chemie --- biochemie --- biologie
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This classic textbook is an introduction to the systematics and the use of stable isotopes in geosciences. It is subdivided into three parts: i) theoretical and experimental principles, ii) fractionation processes of light and heavy elements, iii) the natural variations of geologically important reservoirs. Since the publication of the previous edition advances in multicollector-ICP-mass-spectrometry allow precise measurements of new isotope systems. In this new edition therefore, 42 elements with resolvable natural variations in isotope composition are discussed. New findings from non-traditional isotope systems have been incorporated. Many new references have been added, which enable quick access to recent literature.
Geochemistry --- Hydrosphere --- Geology. Earth sciences --- geochemie --- massaspectrometrie --- geologie --- oceanografie
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Physicochemistry --- Spectrometric and optical chemical analysis --- massaspectrometrie --- fysicochemie --- spectrometrie
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From disease marker identification to accelerated drug development, Protein Arrays, Biochips, and Proteomics offers a detailed overview of current and emerging trends in the field of array-based proteomics. This reference focuses on innovations in protein microarrays and biochips, mass spectrometry, high-throughput protein expression, protein-protein interactions, structural proteomics, and the proteomic marketplace for comprehensive understanding of past, present, and future proteomic research. Offering an abundance of figures and charts, the book compiles a wide variety of technologies and applications ranging from functionalized chip surfaces to strategies for protein expression.
Molecular biology --- Biotechnology --- spectrometry --- bioengineering --- massaspectrometrie --- proteomics --- biotechnologie --- spectrometrie
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543.42 --- absorptiespectrometrie --- chemische analyse --- emissiespectrometrie --- infrarood spectrometrie --- massaspectrometrie --- raman microspectrometrie --- röntgenfluorescentiespectrometrie --- spectrometrie --- spectroscopie --- Spectroscopie --- Absorptiespectrometrie --- Emissiespectrometrie --- Massaspectrometrie --- Röntgenfluorescentiespectrometrie --- IR-spectrometrie --- Raman-spectrometrie
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