Narrow your search

Library

KU Leuven (1758)

KBR (1154)

National Bank of Belgium (348)

UGent (344)

UAntwerpen (321)

VUB (277)

ULB (266)

UCLouvain (224)

ULiège (202)

LUCA School of Arts (140)

More...

Resource type

dissertation (1088)

book (1005)

article (2)

digital (1)

periodical (1)


Language

English (1956)


Year
From To Submit

2023 (4)

2022 (2)

2021 (5)

2020 (3)

2019 (5)

More...
Listing 1 - 10 of 1956 << page
of 196
>>
Sort by

Book
A handbook of plant form for students of design, art schools, teachers & amateurs. One hundred plates comprising nearly 800 illustrations, drawn and described, and with an introductory chapter on design and a glossary of botanical terms
Author:
Year: 1909 Publisher: London Batsford

Loading...
Export citation

Choose an application

Bookmark

Abstract

Keywords

745.043


Book
The principles of stockbreeding
Author:
Year: 1912 Publisher: London Vinton and Co

Loading...
Export citation

Choose an application

Bookmark

Abstract

Keywords

63.6.043


Book
The floral symbolism of the great masters
Author:
Year: 1913 Publisher: London Kegan Paul, Trench, Trübner and Co

Loading...
Export citation

Choose an application

Bookmark

Abstract


Dissertation
Olivine mineralogy of young and evolved stars
Authors: ---
ISBN: 9789086496464 Year: 2013 Publisher: Leuven Katholieke Universiteit Leuven

Loading...
Export citation

Choose an application

Bookmark

Abstract

The spectral characteristics of crystalline olivine can be used as a probe of thephysical and chemical properties of circumstellar environments. In this thesisare presented the first Herschel Space Telescope observations of the 69 µmband of crystalline olivine in the debris disk of ß Pictoris and the circumstellarenvironment of evolved stars. The observed 69 µm band and other features of crystalline olivine are used todetermine the composition and location of the olivine crystals in the youngplanetary system of ß Pictoris. This analysis shows that the olivine crystals arepart of the collisional debris of relatively small (<10 km) comet-like planetesimalsorbiting in a Kuiper belt-like region of the planetary system. It is shown thatthe composition of the crystals is remarkably similar to those in comets of ourSolar System. A large set of Herschel/PACS observations of the 69 µm band of crystallineolivine in the circumstellar environment of evolved stars is presented. Thissample consists out of many different types of evolved stars, among whichOH/IR stars, post-AGB stars and planetary nebulae. The 69 µm bands of thesestars show that all these different types of evolved sources all produce the samepure magnesium-rich crystalline olivine. The OH/IR subsection of the large sample of Herschel/PACS observations isanalyzed in more detail. It is shown that the current and dense superwindof these objects has started no longer than 1200 years ago and that the dustin their outflows contains 2-14 % crystalline olivine (by mass). Depending onthe progenitor mass of the star the short time-scales that are found for thesuperwind causes a conundrum. The stars with a high mass progenitor starneed to go through several of these superwinds in order to lose enough massto leave the Asymptotic Giant Branch. Until now no such previously emittedsuperwinds have been detected as extended shells around such objects and thefurther evolution of these objects is not known.


Dissertation
Metabolic modeling of Streptomyces lividans, a cell factory for heterologous protein production
Authors: ---
ISBN: 9789460187698 Year: 2013 Publisher: Leuven Katholieke Universiteit Leuven

Loading...
Export citation

Choose an application

Bookmark

Abstract

Streptomycetes are worldwide used for commercial production of antibiotics and industrial enzymes. Nowadays, several genera of Grampositive bacteria are being tested as cell factories for the production of heterologous proteins owing to their ability to efficiently secrete proteins in the culture medium. Among them Streptomyces lividans is the cell factory of choice for the secretory production of heterologous proteins. To acquire a commercially attractive secretion yield of heterologous protein, the availability of suitable nitrogen sources in the medium is often essential. A complex mixture of amino acids, e.g., casamino acids, is usually added to the medium for this purpose. Besides acting as building blocks for biomass production, these amino acids are presumed to play an important role in the biosynthesis of heterologous protein. This dissertation focuses on the qualitative and quantitive characterization of the growth and metabolism of S. lividans TK24 as a cell factory for heterologous protein production. Based on a central set of experimental data, amino acids metabolization is investigated and a framework for the analysis of intracellular fluxes in a complex medium is set up. Experiments are performed with the wild-type and heterologous protein producing S. lividans under controlled bioreactor conditions and in the presence of casamino acids. Mouse Tumor Necrosis Factor alpha is taken as a model heterologous protein. First, the metabolic footprint, also called exometabolome (all extracellular metabolites), is thoroughly analyzed for wild-type and recombinant strain grown in a defined medium supplemented with casamino acids. The metabolite concentration profiles and calculated specific conversion rates reveal amino acid uptake preferences, by-products formation, and the impact and relevance of amino acids on biomass growth and heterologous protein production. In view of optimization of heterologous protein production levels in S. lividans, a deeper understanding of the effects of C- and N-substrates on the (intracellular) metabolism is necessary. Analysis of the intracellular metabolic fluxes via metabolic network modeling techniques is the tool of choice to further unravel this metabolism. To this end, a general metabolic modeling framework is developed to determine metabolic fluxes in S. lividans TK24 grown on a nutrient-rich medium. The plethora of substrates taken up motivates the use of a genome-scale metabolic network model, which makes it also possible to thoroughly study the whole-cell effects (metabolic impact) of heterologous protein production on the host cell’s metabolism in a further stadium. A genome-scale metabolic network model for wild-type S. lividans TK24 is constructed first. Next, the obtained experimental data are confronted with this genome-scale model using a combination of constraint-based stoichiometric metabolic network modeling techniques. Genome-scale hierarchical flux balance analysis and randomized sampling of the solution space are combined to extract maximum information from the exometabolome profiles. In this dissertation, new insights into the metabolic background of S. lividans as a cell factory for heterologous protein production are presented. The results are based on a systems approach and industrial relevant bioreactor conditions. Besides the exhaustive metabolic footprinting returning qualitative information, a systematic and integrative approach is presented to address the hurdles encountered in genomescale flux analysis by using a combination of hierarchical flux balance analysis and randomized sampling of the flux solution space. This general approach can easily be adopted in future studies of S. lividans, e.g., as a host for heterologous protein production


Dissertation
Forming simulation of textile reinforced composite shell structures
Authors: ---
ISBN: 9789460180095 Year: 2008 Publisher: Leuven Katholieke Universiteit Leuven

Loading...
Export citation

Choose an application

Bookmark

Abstract

Composietmaterialen kunnen metaal, aluminium of titanium mogelijk vervangen in verscheidene toepassingen als transport, sportartikelen, consumptie artikelen omwille van gewichtsreductie of andere ontwerpredenen. Composieten zijn heterogene materialen, samengesteld uit een versterking en een matrix materiaal. De versterking bestaat meestal uit vezels, en verschaft het composiet stijfheid en sterkte. De matrix is gewoonlijk een plastiek en leidt de krachten door van vezel naar vezel door de vezels onderling te verbinden. Textielcomposieten hebben een textielversterking en vertonen goede weerstand tegen impact en vermoeiing. De productie van schaalproducten uit textielcomposiet vereist het draperen van droge of met matrix geïmpregneerde textielen overheen matrijzen. Tijdens het draperen treden grote vervormingen op in het textiel. Deze vervormingen beïnvloeden de daaropvolgende productiestappen en de productkwaliteit en leiden soms tot vormfouten. De niet-lineaire eindige elementen methode ondersteunt de procesoptimalisatie door de vezelrichtingen en andere vervormingen op het product te voorspellen. Dit vereist de ontwikkeling van specifieke materiaalmodellen die het anisotroop gedrag van deze textielen in rekening brengen en de vezelrichtingen accuraat opvolgen. De eerste doelstelling van dit proefschrift is om twee testmethodes, die het textielgedrag in afschuiving en biaxiale trek karakteriseren, kritisch te evalueren en verbeteren. Deze testen genereren de noodzakelijke invoerdata voor de materiaalmodellen, maar zijn helaas nauwelijks gestandaardiseerd. Een tweede doelstelling betreft het ontwikkelen van een elastisch macroscopisch materiaalmodel dat het drapeergedrag in het vlak accuraat weergeeft. Hiervoor zijn bestaande modellen theoretisch bestudeerd en tweedimensionaal getest. Vervolgens is een nieuw model voorgesteld. Het nieuwe model onderscheidt zich doordat het op een pragmatische manier zowel het trekgedrag als het afschuifgedrag in rekening brengt en arbitraire grote materiaalvervormingen aankan. Tenslotte zijn de voorspelde vezeloriëntaties met experimentele data vergeleken in drie vormgevingsstudies. Hierbij is nagegaan hoe gevoelig de vezeloriëntaties op het product afwijken ten gevolge van wijzigingen in het materiaalgedrag of de procescondities. De plooihouderconfiguratie en matrijsgeometrie waren voor het onderzochte referentiemateriaal de meest invloedrijke parameters. Composites are potential candidates to replace metal, aluminium or titanium for weight reduction or other design reasons in various applications like transportation, sports equipment, consumer goods. Composites are heterogeneous materials composed of a reinforcement and a matrix. The reinforcement usually consists of fibres, and provides the composite stiffness and strength. The matrix is usually a plastic or resin and assures load transfer by binding the fibres together. Textile composites have a textile reinforcement and manifest good impact and fatigue resistance. The production of textile composite shell products requires the drape of dry or matrix-impregnated textile sheets over molds. During the drape forming, the textile undergoes large deformations. These deformations affect the subsequent production steps and final product quality, and may result into drape-related faults. The nonlinear finite element method supports the process optimization by predicting the fibre orientations and other deformations on the product. This requires the development of suitable material models that incorporate the anisotropic drape behaviour of these textiles and that track the fibre orientations. The first objective of the dissertation is to critically evaluate and improve two test methods that characterize the in-plane shear and biaxial tensile behaviour of these textiles. These tests generate necessary input data for the material models, but unfortunately lack standardization. A second objective is the development of an elastic macro-scale material model that accurately incorporates the in-plane drape behaviour. First, state-of-the-art models are theoretically investigated and tested in-plane. Furthermore a new material model is proposed, differing by the fact that it incorporates in a pragmatic manner both typical tensile and shear behaviour, and handles arbitrarily large deformations. Finally, the predicted fibre orientations are compared to experimental data in three forming case studies. Additionally the sensitivity of the fibre orientations to variations in the material data and process conditions are investigated. The blankholder configuration and the mold geometry were the most influential parameters for the studied reference material. Composietmaterialen kunnen metaal, aluminium of titanium mogelijk vervangen in verscheidene toepassingen als transport, sportartikelen, consumptie artikelen omwille van gewichtsreductie of andere ontwerpredenen. Composieten zijn heterogene materialen, samengesteld uit een versterking en een matrix materiaal. De versterking bestaat meestal uit vezels, en verschaft het composiet stijfheid en sterkte. De matrix is gewoonlijk een plastiek en leidt de krachten door van vezel naar vezel door de vezels onderling te verbinden. Textielcomposieten hebben een textielversterking en vertonen goede weerstand tegen impact en vermoeiing. De productie van schaalproducten uit textielcomposiet vereist het draperen van droge of met matrix geïmpregneerde textielen overheen matrijzen. Tijdens het draperen treden grote vervormingen op in het textiel. Deze vervormingen beïnvloeden de daaropvolgende productiestappen en de productkwaliteit en leiden soms tot vormfouten. De niet-lineaire eindige elementen methode ondersteunt de procesoptimalisatie door de vezelrichtingen en andere vervormingen op het product te voorspellen. Dit vereist de ontwikkeling van specifieke materiaalmodellen die het anisotroop gedrag van deze textielen in rekening brengen en de vezelrichtingen accuraat opvolgen. De eerste doelstelling van dit proefschrift is om twee testmethodes, die het textielgedrag in afschuiving en biaxiale trek karakteriseren, kritisch te evalueren en verbeteren. Deze testen genereren de noodzakelijke invoerdata voor de materiaalmodellen, maar zijn helaas nauwelijks gestandaardiseerd. Een tweede doelstelling betreft het ontwikkelen van een elastisch materiaalmodel dat het drapeergedrag in het vlak accuraat weergeeft. Hiervoor zijn bestaande modellen theoretisch bestudeerd en getest. Vervolgens is een nieuw model voorgesteld. Het nieuwe model onderscheidt zich doordat het op een pragmatische manier


Dissertation
Probabilistic graphical models for content representation and applications in monolingual and multilingual settings
Authors: ---
ISBN: 9789460183683 Year: 2011 Publisher: Leuven Katholieke Universiteit Leuven

Loading...
Export citation

Choose an application

Bookmark

Abstract


Dissertation
Wave based modelling techniques for unbounded acoustic problems
Authors: ---
ISBN: 9789460183928 Year: 2011 Publisher: Leuven Katholieke Universiteit Leuven

Loading...
Export citation

Choose an application

Bookmark

Abstract


Dissertation
Automatic detection and classification of argumentation in a legal case
Authors: ---
ISBN: 9789460183966 Year: 2011 Publisher: Leuven Katholieke Universiteit Leuven

Loading...
Export citation

Choose an application

Bookmark

Abstract


Dissertation
New techniques for symbolic execution and state coverage
Authors: ---
ISBN: 9789460183607 Year: 2011 Publisher: Leuven Katholieke Universiteit Leuven

Loading...
Export citation

Choose an application

Bookmark

Abstract

Listing 1 - 10 of 1956 << page
of 196
>>
Sort by