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Disorder. --- Management. --- Obsessive-compulsive disorder. --- Obsessive-compulsive. --- Ocd. --- Stereotypy.

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Disorder. --- Electrical stimulation. --- Human. --- Internal capsule. --- Limb. --- Obsessive-compulsive disorder. --- Obsessive-compulsive. --- Stimulation.

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Obsessive-compulsive disorder --- Obsessive-Compulsive Disorder. --- Obsessive-compulsive disorder. --- Psychiatric Disorders, Individual --- Compulsive disorder --- Fixed ideas --- Obsession (Psychology) --- Obsessive-compulsive neuroses --- Obsessive-compulsive neurosis --- OCD (Disease) --- Neuroses --- Compulsive behavior --- Anankastic Personality --- Neurosis, Obsessive-Compulsive --- Anankastic Personalities --- Disorder, Obsessive-Compulsive --- Disorders, Obsessive-Compulsive --- Neuroses, Obsessive-Compulsive --- Neurosis, Obsessive Compulsive --- Obsessive Compulsive Disorder --- Obsessive-Compulsive Disorders --- Obsessive-Compulsive Neuroses --- Obsessive-Compulsive Neurosis --- Personalities, Anankastic --- Personality, Anankastic --- Compulsive Behavior --- Health Sciences --- Psychiatry & Psychology

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Objective: Investigation of deep brain stimulation (DBS) as a last-resort treatment alternative to capsulotomy in treatment-refractory obsessive-compulsive disorder (OCD). Method: Prospective single-case based design with evaluation of DBS impact on emotions, behaviour, personality traits and executive function in three patients with OCD. Results: Two patients experienced sustained improvement of OCD symptoms with DBS. Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) dropped 12 points and 23 points to baseline and Y-BOCS self-rating scale (Y-BOCS-SRS) and Profile of Mood States (POMS) for depression and tension decreased with increasing stimulation amplitude. Total Maladjustment Score on the Brief Psychiatric Rating Scale reduced with 44 and 59% to baseline. Reduction in psychopathology was sustained under continuous stimulation. No deleterious impact of DBS on neuropsychological testing or personality traits measured on a self-rated personality inventory was detected. Conclusion: These preliminary findings demonstrate that DBS may have important therapeutic benefits on psychopathology in OCD. No harmful side-effects were detected during follow-up (33/33/39 months, respectively)

Behaviour. --- Brain. --- Depression. --- Design. --- Disorder. --- Emotion. --- Function. --- Investigation. --- Method. --- Mood. --- Obsessive-compulsive disorder. --- Obsessive-compulsive. --- Ocd. --- Personality. --- Psychopathology. --- Reduction. --- Stimulation. --- Treatment.

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8-oh-dpat. --- Accumbens. --- Alternation behaviour. --- Behaviour. --- Electrical stimulation. --- Electrolytic lesion. --- Lesion. --- Nucleus accumbens. --- Nucleus-accumbens. --- Nucleus. --- Obsessive-compulsive disorder. --- Obsessive-compulsive. --- Rat. --- Rats. --- Stimulation. --- T-maze.