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Genetics --- Histology. Cytology --- Molecular biology --- cytologie --- histologie --- moleculaire biologie --- genexpressie

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Modern medicine is increasingly focused on integrating the results of basic scientific research and clinical research, translational medicine  to provide improved patient care. This collaborative approach which is a two way street  has proven very useful in various fields in cardiovascular medicine.     Translational Vascular Medicine: Pathogenesis, Diagnosis, and Treatment provides extensive information on new and exciting advances in such topics as surgery and non-pharmacological treatments for atherosclerotic disease of the aorta, pulmonary arterial hypertension, cytoprotective mechanisms in the vasculature, and the Broken Heart Syndrome . The Editors and their expert panel of contributors have explored the bi-directional and integrated approaches of translational cardiovascular medicine, linking basic science to patient care.   This book is a highly useful method to understand these complex topics and provides considerable insight into important areas of translational cardiovascular medicine and key bibliographies for the reader.

Genetics --- Molecular biology --- Human physiology --- Pathology of the circulatory system --- cardiologie --- fysiologie --- moleculaire biologie --- genexpressie

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The silencing of gene expression by small interfering RNAs has been recognized for only a relatively short time, but this has transformed our understanding of both transcriptional and post-transcriptional gene regulatory mechanisms. Multiple pathways culminate in formation of an RNA-induced silencing complex (RISC) containing a member of the Argonaute protein family bound to a 22-nt RNA strand that interacts with a target mRNA or gene through Watson-Crick base pairing. One consequence is mRNA-specific inhibition of protein synthesis. Evidence has been presented for diverse mechanisms, but there is not universal agreement in the field of how RISCs affect the translational machinery. The chapters collected in this volume represent contribution by leaders in the search to understand how miRNAs affect translation. They include chapters representing work in plants and Caenorhabditis elegans, the biological systems that originally led to the discovery of small interfering RNAs, but also include chapters on mammalian systems, with special emphasis on regulation of a key tumor suppressor and a protein that restricts human immunodeficiency virus 1 (HIV-1).

Genetics --- Histology. Cytology --- General biochemistry --- Molecular biology --- biochemie --- cytologie --- histologie --- moleculaire biologie --- genexpressie

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Genetics --- Histology. Cytology --- General biochemistry --- Molecular biology --- Oncology. Neoplasms --- celmembranen --- biochemie --- genetica --- oncologie --- genexpressie

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Genetics --- Histology. Cytology --- General biochemistry --- Molecular biology --- Oncology. Neoplasms --- celmembranen --- biochemie --- genetica --- oncologie --- genexpressie