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Theoretical chemistry has been an area of tremendous expansion and development over the past decade; from an approach where we were able to treat only a few atoms quantum mechanically or make fairly crude molecular dynamics simulations, into a discipline with an accuracy and predictive power that has rendered it an essential complementary tool to experiment in basically all areas of science. This volume gives a flavour of the types of problems in biochemistry that theoretical calculations can solve at present, and illustrates the tremendous predictive power these approaches possess.
General biochemistry
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Biochemistry.
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Analytical biochemistry.
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As in Volumes 35 and 36, the chapters in this new volume complement, with personal recollections, the History of Biochemistry that was covered in the Comprehensive Biochemistry Series, Volumes 30-33 by M. Florkin and Volume 34A by P. Laszlo. The biographical and autobiographical chapters will convey to the reader a lively, albeit at times subjective, view of the scientific and social environment in which the authors have worked, resulting in new concepts and theories on the biological sciences.
General biochemistry --- Biochemistry --- History.
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These volumes are of interest to bioscientists and to historians alike. Many authors, both as individuals and as scientists, lived and worked in the 'age of extremes' in the so-called 'short 20th century', and yet contributed significantly to the unprecedented development of life sciences in this period. These 'oral histories', set against a backdrop of the Second World War, Holocaust, and Stalinist terror, are thus of interest and relevance to older and younger generations alike. Perhaps the lessons learned from these first-hand accounts may contribute in some way to ensuring that future scientists can enjoy the fascination of science undisturbed by the avoidable tragedy of man-made events. The contributors to this volume in the Comprehensive Biochemistry series encompass a wide variety of experiences in many different countries and in very different fields of biochemistry. Some have worked close to the laboratory bench throughout their scientific life and are continuing to do so. Others have been closely engaged in organizational matters, both nationally and internationally. All mention incidents in their own career or have observed those in others that will be of interest to future historians who will record and assess the period in which our contributors have lived and worked. It was an extremely exciting time for the life sciences. It was also a period of major and often tragic historical events that deeply affected the life and work of the generation to which our contributors belong.
General biochemistry --- Biochemistry --- History.
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How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, sequence information, gene organization? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact? The Academic Press FactsBook series will satisfy scientists and clinical researchers suffering from information overload. Each volume provides a catalogue of the essential properties of families of molecules. Gene organization, sequence information, physicochemical properties, and biological activity are presented using a common, easy to follow format. Taken together they compile everything you wanted to know about proteins but were too busy to look for. In a set of four inter-related volumes, The Ion Channel FactsBook provides a comprehensive framework of facts about channel molecules central to electrical signalling phenomena in living cells. The first volume is devoted to Extracellular Ligand-Gated Integral Receptor-Channel Families including those molecular complexes activated by: 5-Hydroxytryptamine, ATP, Glutamate, Acetylcholine, GABA, Glycine. Key Features * Nomenclature * Expression * Sequence analyses * Structure and function * Electrophysiology * Pharmacology * Information retrieval.
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Flow-through sensors are more suitable than classical probe-type sensors for addressing real (non-academic) problems. The external shape and operation of flow-through (bio)chemical sensors are of great practical significance as they facilitate sample transport and conditioning, as well as calibration and sensor preparation, maintenance and regeneration, all of which result in enhanced analytical features and a wider scope of application. This is a systematic presentation of flow-through chemical and biochemical sensors based on the permanent or transient immobilization of any of the ingredients of a (bio)chemical reaction (i.e. the analyte, reagent, catalyst or product) where detection is integrated with the analytical reaction, a separation process (dialysis, gas diffusion, sorption, etc.) or both. The introductory chapter provides an overview of (bio)chemical sensors and their impact on analytical chemistry. Essential concepts of flow-through (bio)chemical sensors including their definition, classification, the types of flow-cells where the sensing microzone can be accommodated, continuous-flow configurations to which they can be coupled, the measurement modes available and the types of transient signals obtained, among others, are the subject of Chapter 2. The remaining chapters classify the most relevant types of flow-through (bio)chemical sensors according to the processes taking place at the sensing (recognition) microzone, as well as their position in space and time. The book deals critically with most types of flow-through sensors, discussing their possibilities and shortcomings to provide a realistic view of the state-of-the-art in the field. The large numbers of figures, the wealth of literature references and the extensive subject index complement the text.
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Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds available. It will be invaluable for everyone who wants to choose the most suitable PDE inhibitor for their research or who is dealing with such drugs in a clinical setting. Key Features * Utilizes actual testing and research of new PDE inhibitors * Valuable for researchers and students alike.
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The Academic Press FactsBooks series has established itself as the best source of easily-accessible and accurate facts about protein groups. Described as 'a growing series of excellent manuals' by Molecular Medicine Today, and 'essential works of reference' by Trends in Biochemical Sciences, the FactsBooks have become the most popular comprehensive data resources available. As they are meticulously researched and use an easy-to-follow format, the FactsBooks will keep you up-to-date with the latest advances in structure, amino acid sequences, physicochemical properties, and biological activity. In a set of four interrelated volumes, The Ion Channel FactsBook provides a comprehensive framework of facts about channel molecules central to electrical signaling phenomena in living cells. The fourth volume is devoted to Voltage-gated Channel Families, including those molecular complexes activated or modulated by calcium, potassium, and chloride. Key Features * Nomenclature * Expression * Sequence Analyses * Structure and function * Electrophysiology * Pharmacology * Information retrieval.
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