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Neuropathology --- Electrodiagnosis --- Nervous system --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Diagnostic Techniques and Procedures --- Diseases --- Nervous System Diseases --- Diagnosis --- Methods

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Human medicine --- Recreation. Games. Sports. Corp. expression --- Sports medicine --- Medicine --- Investigative Techniques --- Wounds and Injuries --- Diseases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Health Occupations --- Disciplines and Occupations --- Athletic Injuries --- Methods --- Sports Medicine

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High Throughput Bioanalytical Sample Preparation: Methods and Automation Strategies is an authoritative reference on the current state-of-the-art in sample preparation techniques for bioanalysis. This book focuses on high throughput (rapid productivity) techniques and describes exactly how to perform and automate these methodologies, including useful strategies for method development and optimization. A thorough review of the literature is included within each of these chapters describing high throughput sample preparation techniques: protein removal by precipitation; equilibrium dialysis and ultrafiltration; liquid-liquid extraction; solid-phase extraction; and various on-line techniques. The text begins with an introductory overview of the role of bioanalysis in pharmaceutical drug development. Fundamental understanding of the strategies for sample preparation is reinforced next, along with essential concepts in extraction chemistry. Several chapters introduce and discuss microplates, accessory products and automation devices. Particular strategies for efficient use of automation within a bioanalytical laboratory are also presented. The subject material then reviews protein precipitation, liquid-liquid extraction, solid-phase extraction and various on-line sample preparation approaches. The book concludes with information on recent advances in sample preparation, such as solid-phase extraction in a card format and higher density extraction plates. Important objectives that can be accomplished when the strategies presented in this book are followed include: improved efficiency in moving discovery compounds to preclinical status with robust analytical methods; return on investment in automation for sample preparation; and improved knowledge and expertise of laboratory staff. Shows the reader exactly how to perform modern bioanalytical sample preparation techniques, complete with detailed strategies Thorough literature review and summary of published information Detailed discussion and examples of the method development process.

Drugs --- Pharmaceutical industry --- Metabolic Phenomena --- Pharmacological Phenomena --- Kinetics --- Natural Science Disciplines --- Investigative Techniques --- Fluids and Secretions --- Chemicals and Drugs --- Evaluation Studies as Topic --- Drug Discovery --- Body Fluids --- Chemistry --- Methods --- Drug Evaluation, Preclinical --- Chemistry Techniques, Analytical --- Metabolism --- Pharmacokinetics --- Pharmaceutical Preparations --- Biochemical Phenomena --- Phenomena and Processes --- Physiological Phenomena --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Anatomy --- Disciplines and Occupations --- Chemical Phenomena --- Analysis --- Technological innovations

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Neuropathology --- Magnetic brain stimulation --- Diseases --- Physics --- Musculoskeletal and Neural Physiological Phenomena --- Physical Stimulation --- Phenomena and Processes --- Investigative Techniques --- Natural Science Disciplines --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Disciplines and Occupations --- Electric Stimulation --- Magnetics --- Nervous System Diseases --- Nervous System Physiological Phenomena

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This book represents an essential reference manual for all of the well-characterized leukemia-lymphoma cell lines currently available. It provides the most important facts, using the succinct and user-friendly format that has made the FactsBooks so popular with scientists and clinical researchers. Introductory chapters provide background and perspective for culturing malignant hematopoietic (blood forming) cell lines. These chapters are followed by over 400 comprehensive individual entries. Each cell line entry highlights essential clinical, immunological, genetic, and functional featur

Human histology. Human cytology --- Human medicine --- Cancer cells. --- Cell Line. --- Cell lines. --- Hematologic Neoplasms. --- Hematopoietic stem cells. --- Human cell culture. --- Leukemia. --- Leukemia, Experimental. --- Leukemia, Experimental--Handbooks, manuals, etc. Lymphomas--Handbooks, manuals, etc. Cancer cells--Handbooks, manuals, etc. Human cell culture--Handbooks, manuals, etc. Hematopoietic stem cells--Handb. --- Lymphoma. --- Lymphomas. --- Research. --- Tumor Cells, Cultured. --- Neoplasms by Histologic Type --- Lymphoproliferative Disorders --- Cells, Cultured --- Culture Techniques --- Neoplasms --- Lymphatic Diseases --- Cells --- Clinical Laboratory Techniques --- Immunoproliferative Disorders --- Anatomy --- Diseases --- Investigative Techniques --- Immune System Diseases --- Hemic and Lymphatic Diseases --- Cell Culture Techniques --- Leukemia --- Lymphoma --- Tumor Cells, Cultured --- Medicine --- Health & Biological Sciences --- Hematologic Diseases