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This book entitled “Cancer Stem Cell Markers and Related Network Path-ways” is about cancer stem cell (CSC) markers and the molecular network pathways. CSCs play an important role in the cancer drug resistance, metastasis and recurrence. Epithelial-mesenchymal transition (EMT) is closely related to CSC phenotype. This book covers various aspects of the molecular networks related to CSCs including the important phenotypic change such as EMT. Readers will discover the importance of the identification of CSC markers and EMT-related molecules in CSC network pathways. The CSC signaling pathways and EMT molecular network pathways attract researchers in the field to define the cancer therapeutic targets. Cancer environment is important in the acquisition of CSC phenotype in cells. The revealing of this CSC mystery is across 7 chapters. The topic of this book is particularly relevant to research in the field of cancer and stem cells, as well as the network pathways. We hope that this book helps the readers to be interested in understanding why the CSC concept is important and attractive.
Biology --- Human genetics --- Medical microbiology, virology, parasitology --- Pathological biochemistry --- Human medicine --- medische microbiologie --- medische biochemie --- medische genetica --- biologie --- biomedische wetenschappen --- Biochemical markers. --- Stem cells. --- Internal Medicine --- Medical --- Cèl·lules mare --- Marcadors bioquímics --- Citodiagnòstic
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This book aims to present the age-related alterations in redox signaling networks and their diagnostic biomarkers in aging cells using multidisciplinary approach. Establishing sensitive and specific biomarkers of dynamic redox homeostasis is crucially important in the development of effective antiaging and senolytic interventions. Recent years have seen tremendous advances in the understanding of redox signaling events which highlight the process of aging and age-related pathologies. A major challenge in biological aging research is developing reliable biomarkers to determine the consequences of disrupted redox signaling networks long before the clinical diagnosis of age-related diseases is made. Therefore, we have chosen to concentrate on aging-induced aberrant redox signaling networks, their biomarkers, and pathological consequences in this book. Although oxidation is a natural metabolic process, the imbalance in the level of oxidants and antioxidants causes oxidative stress and eventually leads to inflammatory conditions, diabetes, neurodegenerative diseases, and cancer. Novel redox-sensitive biomarkers for the evaluation of aging-induced proteinopathies such as amyloid ß and tau proteins in Alzheimer's disease, α-synuclein in Parkinson's disease, and islet amyloid polypeptides in type 2 diabetes mellitus recently drew the attention of researchers. Inside this textbook, readers will find comprehensive perspectives on the association between redox homeostasis and the aging process both at the molecular and clinical levels. Due to the inherent relationship between impaired metabolic activities and oxidative stress, the temporal interaction between intermediary metabolism and disturbed redox status can lead to greater susceptibility to aging-induced diseases and disorders, such as cardiovascular diseases, hypertension, and diabetes. This knowledge could be a key to continued research toward improving medication regimens such as in cancer and cardiovascular therapies, and procedural outcomes for patients. This book brings together current research evidence and knowledge on redox signaling and biomarkers in aging in chapters written by leading global experts in this rapidly evolving field. We hope that this textbook is of interest to a wide group of researchers, advanced students, scientifically curious non-specialist readers and clinicians alike. .
General biochemistry --- Physiology: reproduction & development. Ages of life --- Geriatrics --- veroudering (biologie) --- biochemie --- geriatrie --- Biochemical markers. --- Oxidation-reduction reaction. --- Aging --- Molecular aspects. --- Vellesa --- Marcadors bioquímics --- Oxidació fisiològica --- Reacció d'oxidació-reducció --- Molecular aspects
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Disease --- Disease Susceptibility --- Pathology --- Disease susceptibility --- Pathologie --- Prédisposition morbide --- pathology --- periodicals. --- Periodicals. --- Périodiques --- Pathology. --- Disease Susceptibility. --- Disease susceptibility. --- Pathologies --- Susceptibility, Disease --- Diathesis --- Diatheses --- Disease Susceptibilities --- Susceptibilities, Disease --- Periodicals --- Health Sciences --- Life Sciences --- General and Others --- Cytology, Cell Biology --- Genetics --- Micro and Molecular Biology --- Virology --- disease markers --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Disease predisposition --- Disease proneness --- Predisposition to disease --- Proneness to disease --- Susceptibility to disease --- Constitutional diseases --- Susceptibility --- Causes and theories of causation --- Oncology. Neoplasms --- Human medicine --- Marcadors bioquímics. --- Patologia.
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Amino acids --- Amino Acids. --- Amino acids. --- Acids, Amino --- Amino compounds --- Organic acids --- Peptides --- aminozuren --- Biochemistry --- Amino Acid --- Acid, Amino --- Bioquímica. --- Aminoàcids. --- Àcids aminats --- Àcid glutàmic --- Aminoàcids essencials --- Aminoàcids sulfurosos --- Cisteïna --- Glutamina --- Protamines --- Química biològica --- Química fisiològica --- Biologia --- Medicina --- Química --- Absorció (Fisiologia) --- Anàlisi enzimàtica --- Biodegradació --- Biodisponibilitat --- Bioelectroquímica --- Bioenergètica --- Biogeoquímica --- Biologia molecular --- Bioquímica analítica --- Bioquímica clínica --- Bioquímica física --- Bioquímica quàntica --- Biosíntesi --- Centres actius (Bioquímica) --- Citoquímica --- Composició del cos humà --- Cromatografia --- Digestió --- Enginyeria bioquímica --- Enzimologia --- Equilibri àcid-base --- Fitoquímica --- Fixació de proteïnes --- Genètica bioquímica --- Immunoquímica --- Interfícies biològiques --- Lípids --- Lligands (Bioquímica) --- Marcadors bioquímics --- Metabolisme --- Minerals en l'organisme --- Neuroquímica --- Oxidació fisiològica --- Pigments (Biologia) --- Química biorgànica --- Química clínica --- Química microbiològica --- Quimiotaxi --- Quimiotaxonomia --- Toxicologia bioquímica --- Xenobiòtics --- Histoquímica
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Chemistry --- Chemistry, Physical --- Molecular Biology --- Molecular biology --- Biochemistry --- Biophysics --- Biologie moléculaire --- Biochimie --- Biophysique --- Periodicals. --- Périodiques --- Chemistry. --- Chemistry, Physical. --- Molecular Biology. --- Biochemistry. --- Biophysics. --- Molecular biology. --- Molekül --- Molekülphysik --- Molekularbiologie --- Chemie --- Molecular biochemistry --- Molecular biophysics --- Biological physics --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biochemical Genetics --- Biology, Molecular --- Genetics, Biochemical --- Genetics, Molecular --- Molecular Genetics --- Biochemical Genetic --- Genetic, Biochemical --- Genetic, Molecular --- Molecular Genetic --- Physical Chemistry --- Chemistries, Physical --- Physical Chemistries --- Composition --- Biomolecules --- Systems biology --- Biology --- Medical sciences --- Physics --- Genetic Phenomena --- Molekül --- Molekülphysik --- Genetics & Genomics. --- Molecular Chemistry. --- Molecular Physics. --- moleculaire biologie --- Química. --- Bioquímica. --- Biologia molecular. --- Química física. --- Fisicoquímica --- Física química --- Físico-química --- Fisicoquímica teòrica --- Química física i teòrica --- Química teòrica --- Química --- Absorció --- Afinitat química --- Aire líquid --- Anàlisi instrumental --- Àtoms --- Catàlisi --- Classificació periòdica dels elements --- Col·loides --- Compostos de coordinació --- Condicions i lleis de les reaccions químiques --- Crioscòpia --- Cristal·lització --- Dissociació (Química) --- Electròlisi --- Electroquímica --- Enllaços químics --- Equilibri químic --- Estequiometria --- Estructura química --- Fenòmens de relaxació --- Floculació --- Fotoquímica --- Fusió --- Isomeria --- Mescles --- Moments dipolars --- Pes atòmic --- Pesos moleculars --- Punt crític --- Química atmosfèrica --- Química de l'estat sòlid --- Química de superfícies --- Química física inorgànica --- Química física orgànica --- Química nuclear --- Química quàntica --- Química supramolecular --- Nucleació --- Radioquímica --- Regla de les fases i equilibri --- Solucions (Química) --- Sonoquímica --- Taula periòdica (Química) --- Teoria atòmica --- Teoria molecular --- Termoquímica --- Biofísica molecular --- Bioquímica molecular --- Biofísica --- Bioquímica --- Histoquímica --- Biologia molecular vegetal --- Codi genètic --- Diagnòstic molecular --- Endocrinologia molecular --- Evolució molecular --- Farmacologia molecular --- Genètica molecular --- Glicòmica --- Metabolòmica --- Microbiologia molecular --- Neurobiologia molecular --- Patologia molecular --- Proteòmica --- Reconeixement molecular --- Biomolècules --- Química biològica --- Química fisiològica --- Biologia --- Medicina --- Absorció (Fisiologia) --- Anàlisi enzimàtica --- Biodegradació --- Biodisponibilitat --- Bioelectroquímica --- Bioenergètica --- Biogeoquímica --- Biologia molecular --- Bioquímica analítica --- Bioquímica clínica --- Bioquímica física --- Bioquímica quàntica --- Biosíntesi --- Centres actius (Bioquímica) --- Citoquímica --- Composició del cos humà --- Cromatografia --- Digestió --- Enginyeria bioquímica --- Enzimologia --- Equilibri àcid-base --- Fitoquímica --- Fixació de proteïnes --- Genètica bioquímica --- Immunoquímica --- Interfícies biològiques --- Lípids --- Lligands (Bioquímica) --- Marcadors bioquímics --- Metabolisme --- Minerals en l'organisme --- Neuroquímica --- Oxidació fisiològica --- Pigments (Biologia) --- Química biorgànica --- Química clínica --- Química microbiològica --- Quimiotaxi --- Quimiotaxonomia --- Toxicologia bioquímica --- Xenobiòtics --- Ciència --- Àcids --- Espectroscòpia --- Bases (Química) --- Color --- Combustió --- Condensació --- Cosmoquímica --- Elements químics --- Estereoquímica --- Evaporació --- Explosius --- Farmàcia --- Fermentació --- Foc --- Geoquímica --- Microquímica --- Nanoquímica --- Química agrícola --- Química ambiental --- Química analítica --- Química dental --- Química farmacèutica --- Química física --- Química inorgànica --- Química orgànica --- Química sanitària --- Reaccions químiques --- Sals --- Verins --- Ensenyament de la química --- Gastronomia molecular
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