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This comprehensive volume discusses in vitro laboratory development of insulin-producing cells. It encompasses multiple aspects of islet biology—from embryonic development and stem cell differentiation to clinical studies in islet transplantation, regulation of islet beta-cell regeneration, pancreatic progenitors, mathematical modelling of islet development, epigenetic regulation, and much more. The chapter authors represent leading laboratories from around the world who contribute their international perspectives and global expertise. Collectively, they provide the reader with a concise yet detailed knowledge of processes and current developments in islet regenerative biology. Pancreatic Islet Biology, part of the Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers and clinicians in stem cells or endocrinology, especially those focusing on diabetes. .
Histology. Cytology --- Biology --- Pharmacology. Therapy --- Pathology of the metabolism --- Pathological endocrinology --- Human medicine --- Manufacturing technologies --- farmacologie --- stamcellen --- biologie --- geneeskunde --- diabetes mellitus --- stamceltransplantatie --- histologie --- Stem cells. --- Regenerative medicine. --- Tissue engineering. --- Diabetes. --- Stem Cells. --- Regenerative Medicine/Tissue Engineering.
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This monograph brings forth biomechanical research methods and outcomes on human tissue experiments such as those of the brain and the heart under a single umbrella. Different mechanical characterization techniques employed in human tissue property estimation are presented in detail. The contents also focus on a hyperelastic constitutive model (e.g., Mooney-Rivlin, Ogden) for both isotropic and anisotropic tissue characterization. It also discusses energy dissipation in soft tissues and associated viscoelasticity. Human tissues, including skin, muscles, connective tissues, and tissues in all functional organs are listed and their mechanical properties are presented in detail. These tissue properties are indispensable for computational modeling of biological systems, validation of biomechanical tissue testing, medical simulation through development of artificial phantoms and surrogates, and testing of medical devices and interventions. This book will serve as a key reference for research in tissue engineering & biomedical engineering, medical simulation, biomechanics, finite element modeling of biological systems, biomaterials, biotechnology, implant and medical device development, and healthcare wearables. .
General biophysics --- Pharmacology. Therapy --- Human medicine --- biologische materialen --- geneeskunde --- histologie --- Biomaterials. --- Regenerative medicine. --- Biomedical Materials. --- Regenerative Medicine and Tissue Engineering.
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Bone regeneration --- Tissue engineering --- Bone regeneration. --- Tissue engineering. --- Bones --- Bone --- Regeneration --- Bones. --- Connective Tissue. --- Regenerative Medicine. --- Biomedical engineering --- Regenerative medicine --- Tissue culture --- Bone remodeling --- Regeneration (Biology) --- Bone Regeneration. --- Tissue Engineering. --- Engineering, Tissue --- Organ Culture Techniques --- Tissue Expansion --- Regenerative Medicine --- Guided Tissue Regeneration --- Cell- and Tissue-Based Therapy --- Osteoconduction --- Bone Regenerations --- Regeneration, Bone --- Regenerations, Bone --- Bone Density Conservation Agents --- Microphysiological Systems
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Tissue engineering --- Tissue culture --- Génie tissulaire --- Tissus (Histologie) --- Periodicals --- Périodiques --- Culture --- Tissue Engineering. --- Tissue engineering. --- Engineering, Tissue --- stem cells --- progenitor cells --- Histology. --- Biological Engineering. --- Tissues --- Tissues. --- Biomedical engineering --- Regenerative medicine --- Histology --- Organs (Anatomy) --- Organ Culture Techniques --- Tissue Expansion --- Regenerative Medicine --- Guided Tissue Regeneration --- Cell- and Tissue-Based Therapy --- General biochemistry --- Medicina regenerativa. --- Enginyeria de teixits --- Enginyeria biomèdica. --- Enginyeria clínica --- Enginyeria mèdica --- Bioenginyeria --- Biofísica --- Enginyeria --- Medicina --- Electrònica mèdica --- Materials biomèdics --- Aparells i instruments mèdics --- Enginyeria tisular --- Reconstrucció d'òrgans --- Reconstrucció de teixits --- Cultiu de teixits --- Enginyeria biomèdica --- Medicina regenerativa --- Regeneració (Biologia) --- Microphysiological Systems
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Regenerative medicine --- Immunology --- Tissue engineering --- Immunology. --- Regenerative medicine. --- Tissue engineering. --- Immune System Phenomena. --- Regenerative Medicine. --- Tissue Engineering. --- Engineering, Tissue --- Organ Culture Techniques --- Tissue Expansion --- Regenerative Medicine --- Guided Tissue Regeneration --- Cell- and Tissue-Based Therapy --- Medicine, Regenerative --- Medicines, Regenerative --- Regenerative Medicines --- Regenerative Endodontics --- Immune System Concepts --- Immune System Phenomenon --- Immune System Process --- Immune System Processes --- Concept, Immune System --- Concepts, Immune System --- Immune System Concept --- Phenomena, Immune System --- Phenomenon, Immune System --- Process, Immune System --- Processes, Immune System --- Seroconversion --- Biomedical engineering --- Tissue culture --- Medicine --- Regeneration (Biology) --- Immunobiology --- Life sciences --- Serology --- Microphysiological Systems
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biologische technieken --- apoptose --- contaminatie --- tissue engineering --- in vitro --- Zoohistology. Zoocytology --- biotechnologie --- cytotoxiciteit --- weefselcultuur --- cytologie --- dierlijke cellenkweek --- Celkweek --- Cellenleer --- Cytologie (celleer) --- In vitro vermeerdering --- Animal biochemistry --- PXL-Tech 2016 --- opleiding agro- en biotechnologie --- celbiologie --- experimenten --- Biology
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Bioengineering --- Biomedical Engineering. --- Bioengineering. --- Engineering, Biomedical --- Clinical Engineering --- Engineering, Clinical --- Biomedical Technology --- Biological engineering --- Life science engineering --- Biology --- Engineering --- Synthetic biology --- Molecular biology --- moleculaire biologie --- Health Sciences --- General and Others --- synthetic biology --- biodesign --- biosensors --- tissue engineering
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Biomedical materials --- Biomatériaux --- Periodicals. --- Périodiques --- Biomedical and Dental Materials. --- Biomedical materials. --- biomaterials --- dental materials --- tissue engineering --- Biocompatible materials --- Biomaterials --- Medical materials --- Medicine --- Biomedical engineering --- Materials --- Biocompatibility --- Prosthesis --- Biotechnology --- biotechnologie --- Biomedical Engineering --- Bioartificial materials --- Hemocompatible materials --- Biomaterials (Biomedical materials)
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The book focuses on the emerging anti-aging approaches for maintaining better health in old age. It provides a current understanding of the underlying principle, possible targets, implementation approaches, and efficacy of the various anti-aging strategies. The chapters include a wide range of topics incorporating the major advances in anti-aging strategies, including telomerase activation, stem cell therapy, autophagy induction, sirtuin activation, and dietary restrictions. Further, it discusses the epigenetic mechanisms underlying aging-related processes and epigenetic strategies to delay and reverse aging-related diseases. The book covers the strategy based on tissue engineering and regenerative medicine for understanding the complexity of aging and restoring the functionalities of organ systems. It further presents the applications of melatonin supplementation-based anti-aging therapeutic intervention. Finally, the book reviews the ethical dimension of anti-aging intervention strategies. This book is immensely useful to scientists and researchers from various disciplines in the life sciences. .
Genetics --- Biology --- Pharmacology. Therapy --- Pathological biochemistry --- Human medicine --- medische biochemie --- biologie --- biomedische wetenschappen --- geneeskunde --- genetica --- histologie --- Regenerative medicine. --- Medicine—Research. --- Biology—Research. --- Genetics. --- Epigenetics. --- Regenerative Medicine and Tissue Engineering. --- Biomedical Research.
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This volume of the Springer book series Advances in Experimental Medicine and Biology covers potency assays, one of the most complex yet fundamental evaluations that critically influence stem cell regenerative medicine. Developing potency assays for cell-based medicinal products comes with numerous challenges due to the highly specialised nature of the application and purpose. This book provides the reader with the knowledge necessary to understand issues governing the successful development of potency assays, highlighting an international outlook of how the various challenges raised are being managed. Stakeholders concerned with potency assay development range from patient and clinician to contract research organisations, small and medium enterprise, regulatory authorities and even politicians. The value of potency assays is poised to increase given the inevitable watershed as early-stage clinical trials addressing safety progress to trials testing efficacy. Contributors from clinical, academic, industrial and regulatory sectors establish a broad point of view for guidance and timely debate. Potency assays require extensive collaboration across disciplines and sectors, as well as compromise and the authors aim to constructively address the many key aspects involved. Potency assays provide a quantitative measure of the biological activity of advanced therapy medicinal products (ATMPs) and thus are required for their market authorization. As the pace of ATMP development accelerates, the need to develop specific, accurate, and robust potency assays for each product is also accelerating. The volume Potency Assays for Stem Cell Advanced Therapy Medicinal Products presents a broad outlook on the development, quality attributes, and implementation of potency assays for ATMPs. The first few chapters introduce a nuanced historical perspective on the science of potency assay development, describe specific quality attributes of an idealized potency assay, indicate pitfalls associated with developing such assays for ATMPs, and review guidance recommended by regulatory authorities on assay suitability for product approval. Subsequent chapters highlight efforts to develop potency assays for specific ATMPs, including skeletal stem cells, mesenchymal stromal cells, extracellular vesicles, CAR T-cells, and discuss emerging technologies/platforms for potency assay design. The volume concludes with a chapter reviewing potency assays used for the release of commercial ATMP products, which amalgamates information contained in previous chapters. Overall, the knowledge contributed from leading authorities in both academia and industry is an ideal resource for technicians, scientists, clinicians, process engineers, and regulators working with ATMPs. —Donald G. Phinney, PhD Professor, Department of Molecular Medicine, Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology .
Histology. Cytology --- Pharmacology. Therapy --- Medical microbiology, virology, parasitology --- Human medicine --- medische microbiologie --- geneeskunde --- stamceltransplantatie --- histologie --- Stem cells. --- Regenerative medicine. --- Medical microbiology. --- Stem Cell Biology. --- Regenerative Medicine and Tissue Engineering. --- Medical Microbiology. --- Biology --- Science
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