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Immunology. Immunopathology --- immunologie --- interferon

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The type I interferon (IFN) signaling pathway is well recognized as a pathway activated by viral infections. It is activated by a variety of microbial pattern recognition receptors including the Toll-like receptors, NOD-like receptors and several cytosolic receptors. Activation of the type I IFN pathway leads to the production of both antiviral factors and products that influence immune cell function. More recently it has been shown that bacteria are also capable of activating this pathway. Bacterial Activation of Type I Interferons reviews both the current understanding of how different bacterial species are able to activate this pathway as well as the influence type I IFNs have on the outcome to infection. Several different bacterial species are covered, spanning Gram positive and Gram negative, intracellular, extracellular, and different host infection sites. An introduction to the pathogenesis of each organism is provided, and the signaling molecules involved in the activation of the type I IFN pathway and the role it plays in animal infection models are also covered.

Histology. Cytology --- Biology --- Immunology. Immunopathology --- Infectious diseases. Communicable diseases --- immunologie --- patroonherkenning --- biologie --- bacteriologie --- besmettelijke ziekten --- interferon --- moleculaire biologie

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This book introduces readers to Direct Acting Antiviral (DAAs) agents, newly developed drugs to treat chronic hepatitis C virus infection, which have an excellent anti-viral effect on virus replication. These drugs have been developed to enhance the effect of interferon and ribavirin, as the resistant strains against each drug have been described both in vitro and in vivo and the existences of naturally occurring variants have been reported. However, since the combination of different classes of DAAs is sufficient to completely eradicate the virus without the need for interferon or ribavirin, the current treatment regimen does not include interferon. Ribavirin is used in combination with sofosbuvir, a potent polymerase inhibitor, to enhance its antiviral effects. Hepatitis C Virus Treatment offers readers a comprehensive guide to hepatitis C; describing the resistance profiles against these drugs and shedding light on the difficulties involved in DAA therapy and the direction of future treatments, it will equip doctors to understand the essentials of treating the disease. It also describes in detail new and innovative DAA treatments, the effects of the agents, and the characteristics of resistance, providing cutting-edge information not only for hepatologists, but also for researchers, clinical residents, and medical students.

Pharmacology. Therapy --- Medical microbiology, virology, parasitology --- Gastroenterology --- Human medicine --- resistentie (farmacologie) --- geneesmiddelentolerantie --- medische virologie --- farmacologie --- geneeskunde --- virologie --- gastro-enterologie --- leverziekten --- hepatitis C --- drugs --- interferon --- polymeren

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Tuberculosis --- Tuberculose --- Periodicals. --- Périodiques --- Tuberculosis. --- tuberculosis --- mycobacterium tuberculosis --- Consumption (Disease) --- Lungs --- Phthisis --- Pulmonary tuberculosis --- TB (Disease) --- Chest --- Mycobacterial diseases --- Mycobacterium tuberculosis --- Koch's Disease --- Kochs Disease --- Mycobacterium tuberculosis Infection --- Infection, Mycobacterium tuberculosis --- Infections, Mycobacterium tuberculosis --- Koch Disease --- Mycobacterium tuberculosis Infections --- Tuberculoses --- Antitubercular Agents --- Tuberculin Test --- Interferon-gamma Release Tests --- Diseases --- Human medicine --- Infectious Diseases

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Interferon --- Genetic engineering --- Recombinant proteins --- Genetic Engineering. --- Interferons. --- Recombinant Proteins. --- Genetic engineering. --- Interferon. --- Recombinant proteins. --- Agriculture Sciences --- Chemistry --- Engineering --- Life Sciences --- Agricultural Biotechnology --- Soil Chemistry, Microbiology, Fertility & Fertilizers --- Biochemistry --- Biotechnology --- biotechnology --- biomedicine --- biosciences --- microbiology --- molecular genetics --- immunology --- Genetically engineered proteins --- Proteins --- Interferons --- Designed genetic change --- Engineering, Genetic --- Gene splicing --- Genetic intervention --- Genetic surgery --- Proteins, Biosynthetic --- Proteins, Recombinant DNA --- Biosynthetic Proteins --- DNA Recombinant Proteins --- DNA Proteins, Recombinant --- Proteins, DNA Recombinant --- Proteins, Recombinant --- Recombinant DNA Proteins --- Recombinant Proteins, DNA --- Intervention, Genetic --- Genetic Intervention --- Genetic Interventions --- Interventions, Genetic --- Recombinant molecules --- Antineoplastic agents --- Antiviral agents --- Glycoproteins --- Lymphokines --- Genetic recombination --- Transgenic organisms --- Bioreactors --- Viral Interference --- Cloning, Molecular --- DNA, Recombinant --- Industrial Microbiology --- Artificial Gene Fusion --- Organisms, Genetically Modified --- Animals, Genetically Modified --- Plants, Genetically Modified --- biotechnologie --- Biosynthetic Protein --- Recombinant Protein --- Protein, Biosynthetic --- Protein, Recombinant