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This book brings together an international group of clinicians and researchers from a broad swath of inter-related disciplines to offer the most up-to-date information about clinical and preclinical research into ketamine and second-generation “ketamine-like” fast-acting antidepressants. Currently available antidepressant medications act through monoaminergic systems, are ineffective for many individuals suffering from depression, and are associated with a delayed onset of peak efficacy of several months. The unexpected emergence of ketamine, an anesthetic N-methyl-D-aspartate (NMDA) receptor antagonist, as a rapid-acting antidepressant has reinvigorated CNS drug discovery research and catalyzed investigation in patient populations historically ignored in antidepressant drug development programs, particularly treatment-resistant patients and those with suicidality. Recent industry and academic research efforts have coalesced to explore NMDA receptor and glutamatergic molecular targets that lack ketamine’s psychotomimetic side effects and abuse liability but retain its rapid onset of efficacy. However, many fundamental questions remain regarding the neurobiological mechanisms underlying ketamine’s rapid antidepressant effects and the puzzling persistence of benefits observed in some patients following a single dose. This book examines how insights from these studies are forging new conceptual models of the neurobiology of stress-related affective, anxiety, and addictive disorders and the nature of treatment resistance. It also discusses how ketamine’s rapid antidepressant effects provide a scientific platform to facilitate innovation in clinical trial designs pertaining to patient selection, choice of control group, outcome measures, and dose-optimization. This book brings together data and insights from this rapidly expanding and extraordinarily promising field of study. Readers will be able to extract integrated themes and useful insights from the material contained in these diverse chapters and appreciate the paradigm-shifting contributions of ketamine to modern psychiatry and clinical neuroscience research. .

Pharmacology. Therapy --- farmacologie --- psychofarmaca

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This book is a comprehensive resource on psychotropic medications, detailing the latest methods for defining their characteristics, their use in different patient populations, and drug-drug interactions; an important collection of information forclinicians, students, researchers, and members of the pharmaceutical industry alike. The first section provides the foundational principles of these drugs. Mathematical modeling of parameters that affect their entryto,and exit from, the central nervous system (CNS) compartment are presented on an individual basis and then applied to target populations with specific disease states. Methods and characteristics that inform the transfer of these drugs from the laboratory bench to use in patient care are discussed, including imaging techniques, genetics and physiological barriers, such as the blood-brain barrier. The second section describes the characteristics of specific agents,nominally arranged intodifferent therapeutic categories and with reference crossover use in different disease states. The pharmacologic characteristics of different drug formulations are explored in the context of their ability to improve patient adherence. The third section focuses on drug-drug interactions.Psychotropic medications from different categories are frequently prescribed together,or alongside medications used to treat comorbid conditions, and the information provided is directly relevant to the clinic, as a result. The clinical application of pharmacokinetics and pharmacodynamics of CNS agents has made significant progress over the past 50 years and new information is reported by numerous publications in psychiatry, neurology, and pharmacology.Our understanding of the interrelationship between these medications, receptors, drug transporters, as well as techniques for measurement and monitoring their interactions,isfrequently updated. However, with information presented on a host of different platforms, and in different formats, obtaining the full picture can be difficult. This title aims to collate this information into a single source that can be easily interpreted and applied towards patient care by the clinical practitioner, and act as a reference for all others who have an interest in psychopharmacological agents.

Pharmacology. Therapy --- farmacologie --- psychofarmaca --- drugbeleid

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Antiepileptic Drug Interactions: A Clinical Guide, Second Edition provides a pocket-sized, systematic description of the most clinically relevant drug interactions that occur between AEDs and also between AEDs and non-AEDs. AEDs are presented alphabetically and by drug class in three sections for easy access: Drug interactions between AEDs; Drug interactions between AEDs and non-AEDs: Interactions affecting AEDs; and Drug interactions between AEDs and non-AEDs: Interactions affected by AEDs.   Antiepileptic Drug Interactions: A Clinical Guide, Second Edition should help physicians make more rational choices when polytherapy regimens are indicated and should be of interest to all who treat patients with epilepsy: neurologists and neurosurgeons, trainees at all levels, general practitioners and epilepsy nurse specialists.

Pharmacology. Therapy --- Neuropathology --- farmacologie --- hersenen --- neurochirurgie --- psychofarmaca

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This concise guide provides psychiatrists (including trainees) and general practitioners with a comprehensive overview of the most clinically relevant assessment scales and tools in order to assist with and enhance diagnostic outcomes in depression. Depression is one of the most common mood disorders across the globe, with a lifetime prevalence across all people of 8-10%. Despite being relatively common, depression remains severely underdiagnosed across all age groups and nationalities.

Pharmacology. Therapy --- Psychiatry --- psychiatrie --- farmacologie --- psychotherapie --- psychofarmaca

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Dit boek biedt een toegankelijk overzicht van alle facetten van de moderne psychiatrie: van diagnose tot behandeling. Daarbij wordt nadrukkelijk ingegaan op innovatieve bewegingen in de Nederlandse GGZ, zoals eigen regie, herstel, gezamenlijke besluitvorming, zelfmanagement en ervaringsdeskundigheid. Het boek is gericht op iedereen die in zijn werk of studie te maken krijgt met psychische problematiek.De zesde druk van Psychiatrie: Van diagnose tot behandeling is inhoudelijk verbeterd, geactualiseerd en uitgebreid, waardoor het completer is geworden. De nieuwe opmaak met tal van illustraties maakt het boek aantrekkelijker en overzichtelijker. In ieder hoofdstuk is een studieblok opgenomen met samenvattingen, kernbegrippen en doelen. Ook biedt deze editie studenten ruime mogelijkheden om hun kennis en inzicht te oefenen en te toetsen met flashcards én 260 multiplechoicevragen. De uitgebreide website bij dit boek heeft behalve links naar video's, films, websites en boeken, ook videoclips die belangrijke aspecten van de hoofdstukken toelichten. Door deze toevoegingen offline en online is het boek uitermate geschikt als studiemateriaal.Een ander belangrijk nieuw element zijn de psycho-educatieve teksten. Deze maken duidelijk wat zorgprofessionals te bieden hebben, maar vooral wat cliënten en hun directe omgeving zélf kunnen doen. Hiermee richt het boek zich ook op mensen met psychische problematiek.Psychiatrie: Van diagnose tot behandeling is geschreven door drs. Ron van Deth. Hij is psycholoog en publicist en verbonden aan het Europees Instituut voor Educatie in Driebergen. Hij was jarenlang eindredacteur van PsychoPraktijk en schreef onder andere Psychotherapie: Van theorie tot praktijk, Inleiding in de psychopathologie en (als co-auteur) Pedagogische adviezen voor speciale kinderen.

Psychiatry --- sociale psychiatrie --- psychotherapie --- psychofarmaca --- psychodiagnostiek