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Book
Celdeling en kanker : de genetische basis van een ontregeling.
Authors: --- ---
ISBN: 907303535X Year: 1995 Publisher: Maastricht Natuur en techniek

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Abstract

Wanneer onderzoekers ziekten en andere lichamelijke afwijkingen bestuderen, komen ze vaak veel aan de weet over dewetmatigheden van normale levensprocessen. Dat gaat zeker op bij pogingen om de oorzaken van kanker te achterhalen. Dat onderzoek heeft allerlei inzichten opgeleverd over de normale vermeerdering en ontwikkeling van cellen. Deze verhelderingen en de bijdragen daarvan in de strijd tegen kanker vormen de kern van dit uniek boek. Celdeling en kanker is geschreven door twee vooraanstaande en vermaarde biomedische onderzoekers: Harold Varmus en Robert Weinberg. Zij laten zien hoe bepaalde inzichten in het verschijnsel kanker ons begrip van normale biologische functies hebben verhelderd. Wat verstoort nu eigenlijk de fundamentele regelmechanismen van celgroei, en waardoor ontstaat de onbelemmerde, onvoorspelbare woekering die kenmerkend is voor het begin van kanker? In Celdeling en kanker lezen we hoe onderzoekers deze vragen hebben verkend door het ontstaan van kanker, de carcinogenese, tot in de vroegst waarneembare, submicroscopische stadia te volgen. Puttend uit klassieke en recente onderzoeksresultaten, leggen de auteurs uit hoe erfelijke aanleg kan samengaan met andere factoren (zoals zonlicht, straling, tabak of bepaalde virusinfecties) waardoorde genetische code radicaal verandert en een normaal gen in een kankerverwekkend gen verandert. Varmus en Weinberg beschrijven wat er bekend is over de werking van genen die kanker lijken te bevorderen (de oncogenen) en van tumor-suppressorgenen, die het optreden van tumoren juist voorkomen en inperken. De auteurs besluiten met een vooruitblik op mogelijke manieren om kanker te beheersen, gebaseerd op huidige vorderingen in het onderzoek. Dit boek is een verslag van de frontlinies van een van de belangrijkste en boeiendste wetenschappelijke ondernemingen van deze tijd. Door te lezen over het onderzoek naar het ontstaan, de aard en de mechanismen van kanker krijgt men meer inzicht in de natuurlijke ontwikkeling [onvolledig]

Keywords

Molecular biology --- Oncology. Neoplasms --- Carcinogens. --- Oncogenes. --- Cell Transformation, Neoplastic. --- Cancer cells --- 001 wetenschappen --- 616-006 --- 616-008 --- celdeling --- genetica --- kanker --- oncologie --- 600.2 --- 605.91 --- DNA --- biologie --- celdelingen --- erfelijkheidsleer --- exacte wetenschappen --- geneeskunde --- gezondheidszorg --- kwaadaardige gezwellen --- proto-oncogenen --- therapie --- tumor-suppressorgenen --- 616 --- Celdeling --- Kanker --- kwaadaardige gezwellen (kanker, sarcoom) --- oncologie (gezwelziekten) --- Celbiologie en kanker --- Cells --- Pathology, Cellular --- Neoplastic Cell Transformation --- Transformation, Neoplastic Cell --- Tumorigenic Transformation --- Neoplastic Transformation, Cell --- Cell Neoplastic Transformation --- Cell Neoplastic Transformations --- Cell Transformations, Neoplastic --- Neoplastic Cell Transformations --- Neoplastic Transformations, Cell --- Transformation, Cell Neoplastic --- Transformation, Tumorigenic --- Transformations, Cell Neoplastic --- Transformations, Neoplastic Cell --- Transformations, Tumorigenic --- Tumorigenic Transformations --- Cell Line, Transformed --- Oncogene --- Transforming Gene --- Transforming Genes --- Gene, Transforming --- Genes, Transforming --- Oncogens --- Tumor Initiators --- Tumor Promoters --- Initiators, Tumor --- Promoters, Tumor --- Benzidines --- Neoplasms --- Erfelijkheidsleer --- Oncologie --- (zie ook: endocrinologie, gynecologie, hematologie) --- Carcinogenesis --- Oncogenes --- CELL TRANSFORMATION, NEOPLASTIC --- Kanker. --- Carcinogenesis. --- CELL TRANSFORMATION, NEOPLASTIC. --- Cell transformation, neoplastic. --- Carcinogens --- Cell Transformation, Neoplastic --- Carcinogen --- Oncogen --- Tumor Initiator --- Tumor Promoter --- Initiator, Tumor --- Promoter, Tumor

Air quality guidelines for Europe
Author:
ISSN: 03782255 ISBN: 9289013583 9789289013581 Year: 2000 Volume: no. 91 Publisher: Copenhagen : OMS (Organisation Mondiale de la Santé), bureau régional de l'Europe = W.H.O., regional office for Europe,

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Keywords

Air Pollutants --- Air Pollution --- Carcinogens. --- Air --- -Air quality management --- -Environmental monitoring --- -351.777 EUR --- Biomonitoring (Ecology) --- Ecological monitoring --- Environmental quality --- Monitoring, Environmental --- Applied ecology --- Environmental engineering --- Pollution --- Air pollution control --- Air quality --- Control of air pollution --- Environmental protection --- Atmosphere --- Oncogens --- Tumor Initiators --- Tumor Promoters --- Initiators, Tumor --- Promoters, Tumor --- Benzidines --- analysis. --- adverse effects. --- prevention & control. --- -Analysis --- -Measurement --- Monitoring --- Measurement --- Control --- Management --- Europe. --- Northern Europe --- Southern Europe --- Western Europe --- Air Pollution, Indoor --- Environmental Exposure --- prevention and control --- Air Pollution. --- Environmental Monitoring. --- Air quality management --- Environmental monitoring --- Carcinogens --- 351.777 EUR --- Analysis --- analysis --- adverse effects --- prevention & control --- toxicity --- Analysis. --- Carcinogen --- Oncogen --- Tumor Initiator --- Tumor Promoter --- Initiator, Tumor --- Promoter, Tumor --- Environmental monitoring. --- Air Pollution - prevention and control --- Air Pollutants - adverse effects --- Air Pollutants - toxicity --- Air Pollution, Indoor - prevention and control --- Air - Pollution - Analysis - Europe --- Air quality management - Europe --- Environmental monitoring - Europe --- AIR POLLUTION --- STANDARDS, LEGAL AND PERMISSIVE --- ORGANIC COMPOUNDS --- INDUSTRIAL CHEMICALS --- ENVIRONMENTAL POLLUTION --- BIOLOGICAL STUDIES


Book
Summary report on the evaluation of short-term tests for carcinogens (collaborative study on In Vivo tests)
Author:
ISSN: 0250863X ISBN: 9241571098 Year: 1990 Volume: vol 109 Publisher: Geneva WHO

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Keywords

Carcinogenese -- Testen --- Carcinogenese -- Tests --- Carcinogenicity testing --- Determination de la mutagenicite --- Mutagenicity testing --- Mutageniteitsbepaling --- Carcinogens --- Mutagens --- Mutagenicity Tests --- Evaluation Studies as Topic --- analysis --- Biological Assay. --- Carcinogenicity Tests. --- Evaluation Studies as Topic. --- Mutagenicity Tests. --- 576.385.5 --- .001.4 --- $?$91/02 --- Kanker --- Tests, Genetic Toxicity --- Toxicity Tests, Genetic --- Genetic Toxicity Tests --- Genotoxicity Tests --- Mutagen Screening --- Genetic Toxicity Test --- Genotoxicity Test --- Mutagen Screenings --- Mutagenicity Test --- Screening, Mutagen --- Screenings, Mutagen --- Test, Genotoxicity --- Tests, Genotoxicity --- Toxicity Test, Genetic --- Carcinogenicity Tests --- Critique --- Evaluation --- Evaluation Indexes --- Evaluation Methodology --- Evaluation Report --- Evaluation Research --- Methodology, Evaluation --- Pre-Post Tests --- Qualitative Evaluation --- Quantitative Evaluation --- Theoretical Effectiveness --- Use-Effectiveness --- Critiques --- Effectiveness, Theoretical --- Evaluation Methodologies --- Evaluation Reports --- Evaluation, Qualitative --- Evaluation, Quantitative --- Evaluations --- Evaluations, Qualitative --- Evaluations, Quantitative --- Indexes, Evaluation --- Methodologies, Evaluation --- Pre Post Tests --- Pre-Post Test --- Qualitative Evaluations --- Quantitative Evaluations --- Report, Evaluation --- Reports, Evaluation --- Research, Evaluation --- Test, Pre-Post --- Tests, Pre-Post --- Use Effectiveness --- Carcinogen Tests --- Carcinogenesis Tests --- Carcinogenic Activity Tests --- Carcinogenic Potency Tests --- Tumorigenicity Tests --- Carcinogen Test --- Carcinogenesis Test --- Carcinogenic Activity Test --- Carcinogenic Potency Test --- Carcinogenicity Test --- Potency Test, Carcinogenic --- Potency Tests, Carcinogenic --- Test, Carcinogen --- Test, Carcinogenesis --- Test, Carcinogenic Activity --- Test, Carcinogenic Potency --- Test, Carcinogenicity --- Test, Tumorigenicity --- Tests, Carcinogen --- Tests, Carcinogenesis --- Tests, Carcinogenic Activity --- Tests, Carcinogenic Potency --- Tests, Carcinogenicity --- Tests, Tumorigenicity --- Tumorigenicity Test --- Assay, Biological --- Assays, Biological --- Biologic Assay --- Biologic Assays --- Bioassay --- Assay, Biologic --- Assays, Biologic --- Bioassays --- Biological Assays --- Cancer --- Biological Assay

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