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This book was adapted from graduate courses on signal transduction taught by the editor, where the need for a good overview of recent developments on each of the topics being discussed became apparent. Given the wide range of research topics in signaling, a selection was made that not only reflects the current research interest, but also anticipates those areas that will continue to be of interest over the next several years. The health-relatedness of research was a major criterion for selection, as can be seen in the list of topics covered, such as G protein coupled receptors, growth factors, nuclear receptors, reactive oxygen and nitrogen species, the cell cycle and cancer. The emphasis is on areas of signaling research with direct clinical significance. Another field covered, one rarely highlighted in signal transduction books, is that of signaling platforms, which has been emerging as a significant research area relevant to cellular metabolism, cell proliferation, differentiation, apoptosis, neurodegenerative diseases, and cancer.
Chemical structure --- Chemistry --- Histology. Cytology --- Molecular biology --- Pharmacology. Therapy --- moleculaire structuur --- protein-ligand binding constant --- protein-engineering --- cytologie --- histologie --- eiwitten --- moleculaire biologie --- proteïnen
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Biological processes are driven by complex systems of functionally interacting signaling molecules. Thus, understanding signaling molecules is essential to explain normal or pathological biological phenomena. A large body of clinical and experimental data has been accumulated over these years, albeit in fragmented state. Hence, systems biological approaches concomitant with the understanding of each molecule are ideal to delineate signaling networks/pathways involved in the biologically important processes. The control of these signaling pathways will enrich our healthier life. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities. This encyclopedia presents 350 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world's foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike During past years, there were multiple databases to gather this information briefly and very partially. Amidst the excitement of these findings, one of the great scientific tasks of the coming century is to bring all the useful information into a place. Such an approach is arduous but at the end will infuse the lacunas and considerably be a streamline in the understanding of vibrant signaling networks. Based on this easy-approach, we can build up more complicated biological systems.
Chemical structure --- Biomathematics. Biometry. Biostatistics --- Histology. Cytology --- Molecular biology --- Pharmacology. Therapy --- moleculaire structuur --- protein-ligand binding constant --- protein-engineering --- bio-informatica --- farmacologie --- cytokines --- cytologie --- groeifactoren --- histologie --- eiwitten --- biometrie --- moleculaire biologie
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Sequencing projects have revealed the presence of at least several hundred receptor kinases in a typical plant genome. Receptor kinases are therefore the largest family of primary signal transducers in plants, and their abundance suggests an immense signaling network that we have only just begun to uncover. Recent research findings indicate that individual receptor kinases fulfill important roles in growth and development, in the recognition of pathogens and symbionts or, in a few examples, in both growth and defense. This volume will focus on the roles of receptor kinases, their signaling pathways, and the ways in which these important signaling proteins are regulated.
Chemical structure --- Biomembranes --- Histology. Cytology --- Molecular biology --- Plant physiology. Plant biophysics --- Pharmacology. Therapy --- systematische plantkunde --- moleculaire structuur --- membranen (biologie) --- protein-ligand binding constant --- protein-engineering --- farmacologie --- biologie --- cytologie --- histologie --- eiwitten --- moleculaire biologie
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This volume is a collection of the contributions presented at the 42nd Erice Crystallographic Course whose main objective was to train the younger generation on advanced methods and techniques for examining structural and dynamic aspects of biological macromolecules. The papers review the techniques used to study protein assemblies and their dynamics, including X-ray diffraction and scattering, electron cryo-electron microscopy, electro nanospray mass spectrometry, NMR, protein docking and molecular dynamics. A key theme throughout the book is the dependence of modern structural science on multiple experimental and computational techniques, and it is the development of these techniques and their integration that will take us forward in the future.
Chemical structure --- Chemical and physical cristallography --- Biomathematics. Biometry. Biostatistics --- Pharmacology. Therapy --- Artificial intelligence. Robotics. Simulation. Graphics --- moleculaire structuur --- kristallografie --- protein-ligand binding constant --- protein-engineering --- bio-informatica --- farmacologie --- vormgeving --- simulaties --- eiwitten --- biometrie --- moleculaire biologie
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This volume comprises papers presented at the 40th Erice Course From Molecules to Medicine: Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism , May 29 to June 8, 2008. The papers span the breadth of material presented, which emp- size the practical aspects of modern macromolecular crystallography and its applications to medicine. Topics addressed span from the selection of targets, through to structure determination, interpretation and exploitation. A particular theme that emerges is the dependence of modern structural science on multiple experimental and computational techniques. It is both the development of these techniques and their integration that will take us forward in the future. The NATO ASI directors worked alongside, and offer deep gratitude to Prof. Sir Tom Blundell, Director of the International School of Crystal- graphy, Dr Colin Groom, Dr Neera Borkakoti, Dr John Irwin and Prof. Lodovico Riva di Sanseverino, who were in turn supported by a number of local facilitators. The course was financed by NATO as an Advanced Study Institute. Additional support was given by the European Crystallographic Association, the International Union of Biochemistry and Molecular Biology, the Int- national Union of Crystallography, the University of Bologna, AstraZeneca, Roche, Merck & Co., Boehringer Ingelheim, Bruker Corporation, Douglas Instruments, Informa UK, the Department of Pharmaceutical Chemistry, TTP Lab Tech, University of California at San Francisco. Joel L. Sussman and Paola Spadon
Chemical structure --- Chemical and physical crystallography --- Biomathematics. Biometry. Biostatistics --- Pharmacology. Therapy --- Artificial intelligence. Robotics. Simulation. Graphics --- moleculaire structuur --- kristallografie --- protein-ligand binding constant --- protein-engineering --- bio-informatica --- farmacologie --- vormgeving --- simulaties --- eiwitten --- biometrie --- KI (kunstmatige intelligentie) --- moleculaire biologie
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De scheikunde handelt over de samenstelling en de eigenschappen van de materie en de veranderingen ervan ten gevolge van chemische reacties. De samenstelling en de eigenschappen van de materie worden besproken in het eerste deel van dit studieboek. In het tweede deel staat dan de chemische reactie centraal. Het boek munt uit door zijn duidelijke structuur en heldere formuleringen - resultaat van de jarenlange ervaringen van de auteur. Het omvat tientallen overzichtelijke figuren en tabellen en ook talrijke uitgewerkte voorbeelden. Naast het verwerven van kennis van de theoretische begrippen leert het ook deze kennis toepassen voor het oplossen van concrete problemen.
54 --- 54 Chemistry. Mineralogical sciences --- Chemistry. Mineralogical sciences --- Chemistry --- atoomstructuur --- stoechiometrie --- elektrochemie --- orbitalen --- zuur-base reactie --- 54.04 --- chemisch evenwicht --- chemische bindingen --- chemische reacties --- intermoleculaire krachten --- materie --- periodieke eigenschappen --- stoichiometrie --- tabellen --- zuurbasereacties --- Chemie --- 541 --- scheikunde --- atomen --- Chemische reacties --- Zuur-base evenwicht --- Vloeistoffen --- Vaste stoffen --- Oxydatie --- reductie --- Thermodynamica --- kinetica --- Elektrochemie --- Atomen --- Binding --- Chemietabellen --- Evenwicht (chem.) --- Kinetica --- Materie --- Mendeljev --- Moleculen --- Stoichiometrie --- Zuur-base --- chemie --- scheikunde (ler) --- Algemene chemie --- Scheikunde --- chemische eigenschappen en constanten --- Inleidingen - Hand- en leerboeken Chemie --- Chemische binding --- Zuren --- Basen --- Oxidoreductiereacties --- Neerslag --- Complexatie --- Oplosbaarheid --- Chemie : oefeningen --- Electrochemistry --- Matter physics --- oxidatie --- materie (fysica) --- thermodynamica --- periodiek systeem --- algemene chemie. --- Handbooks, manuals, etc. --- 54 Chemie. Kristallografie. Mineralogie --- Chemie. Kristallografie. Mineralogie --- Higher education
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Speci?c binding of a ligand to a receptor is a key step in a variety of biol- ical processes, such as immune reactions, enzyme cascades, or intracellular transport processes. The ligand-receptor terminology implies that the rec- tor molecule is signi?cantly larger than the ligand, and the term bioactive conformation usually characterizes the conformation of a ligand when it is bound to a receptor. In a more general sense, bioactive conformation applies toanymoleculeinabiologicallyrelevantboundstateregardlessofsizecons- erations. Mostofthecontributions tothisbookaddressligandsthat aremuch smaller than their receptors. X-ray crystallography and high resolution NMR spectroscopy are the two main experimental techniques used to study bioactive conformations. The- fore,the twovolumes ofthisbookcover approachesthat use either ofthetwo techniques, or a combination thereof. The combination of X-ray crystallog- phy and NMR spectroscopy is particularly useful when a crystal structure of areceptorprotein,butnotofthereceptorprotein-ligandcomplex,isavailable. Anumberofexperimentaltechniquestoanalyzethebioactiveconformationof aligandwithNMRarebasedontheobservationoftheresonancesignalsofthe free ligand that is in exchange with the bound ligand. Several chapters focus onsuchapproachesthat rangefromclassical transferredNOEexperiments, totransferred dipolar couplings,toSTD (saturation transfer difference) NMR techniques. Incaseswhere tightbinding inthesub-nanomolar rangeprevents the analysis of the bioactive conformation via free ligand signals, the ligand- proteincomplexhas tobeanalyzed withproteinNMR-based techniques orby crystallography.Sincethisareahasbeenthesubjectofmanyreviewsandmo- graphsitwill not be covered here in particular detail. As a unifying theme, all contributionstargetthequestionofhowmolecular recognitionofbiologically active molecules is achieved on the atomic scale. Depending on the research topic the results from these studies have a strong impact not only in basic research but also in several ?elds of application ranging frompharmaceutical applications tothe use of biomolecules as, for example, cryoprotectants.
Chemistry. --- Organic Chemistry. --- Biochemistry, general. --- Physical Chemistry. --- Medicinal Chemistry. --- Analytical Chemistry. --- Analytical biochemistry. --- Chemistry, Organic. --- Physical organic chemistry --- Biochemistry. --- Chimie --- Biochimie analytique --- Chimie organique --- Chimie organique physique --- Biochimie --- Conformational analysis --- Bioactive compounds --- Ligand binding (Biochemistry) --- Molecular Conformation --- Binding Sites --- Ligands --- Nuclear Magnetic Resonance, Biomolecular --- Protein Binding --- Analysis --- Chemistry --- Biochemistry --- Physical Sciences & Mathematics --- 577.354.3 --- Chemoreception --- 577.354.3 Chemoreception --- Conformational analysis. --- Analysis. --- Binding, Ligand (Biochemistry) --- Analysis, Conformational --- Biologically active compounds --- Compounds, Bioactive --- Compounds, Biologically active --- Compounds, Physiologically active --- Physiologically active compounds --- Analytical chemistry. --- Organic chemistry. --- Physical chemistry. --- Medicinal chemistry. --- Dye-ligand affinity chromatography --- Radioligand assay --- Molecular rotation --- Chemicals --- Chemistry, Physical organic. --- Analytic biochemistry --- Chemistry, Analytic --- Chemistry, Physical organic --- Chemistry, Organic --- Chemistry, Physical and theoretical --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Organic chemistry --- Composition --- Bioanalytic chemistry --- Bioanalytical chemistry --- Analytical chemistry --- Analysis, Chemical --- Analytic chemistry --- Chemical analysis --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Chemistry, Theoretical --- Physical chemistry --- Theoretical chemistry --- Bioactive compounds - Analysis
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Eerste hulp bij hechting is een pleidooi voor effectieve hulp aan ouders en hun jonge kinderen, wanneer zij onvoldoende op elkaar afgestemd raken. Factoren van buitenaf spelen een belangrijke rol bij het ontstaan van de verstoring in de hechting: een vroeggeboorte, een moeilijke zwangerschap, familieproblemen of onveilige hechtingspatronen van de ouders in hun eigen jeugd zijn hier voorbeelden van. Het risico is aanwezig dat negatieve interactiepatronen zich mettertijd zullen versterken. Daarom is het onderkennen ervan in een vroeg stadium belangrijk. Evenals het bieden van hulp daarbij.Paulien Kuipers gaat diepgaand in op de essentie van het werk van de 'hechtingstherapeut'. Ze beschrijft hoe de therapeut de band tussen ouders en kind positief kan beïnvloeden en hoe in een hulptraject bestaande uit één tot vijf stappen ouders en kind beter op elkaar afgestemd kunnen raken. Aan de hand van de vele praktijkvoorbeelden maakt ze duidelijk hoe de taal - woorden van het hart - kan helpen om de band tussen ouders en kind te helen en de liefde tussen hen opnieuw te laten stromen. Het blijkt dat ook het jonge kind van meet af aan gevoelig is voor taal en de diepere betekenis van woorden.Nieuw is het ééngespreksmodel en het vijfstappenmodel voor de hulpverlener, die zij in dit boek presenteert.
ouders --- jeugdhulpverlening --- hechting (psychologie) --- Developmental psychology --- Orthopedagogics --- ouders-kind relatie --- bodemloosheidsyndroom --- Hechtingsstoornissen --- ouder-kind relatie --- 159.92 --- PXL-Healthcare 2019 --- hechtingsstoornissen --- gedragsproblemen --- jonge kind --- Gehechtheidsrelatie --- Ouder-kindrelatie --- Ontwikkelingspsychologie --- Baby's --- Adoptiegezinnen --- Pleeggezinnen --- Prematuriteit --- Ouder-kind binding --- Hechting --- Hechtingsproblemen --- Relatie ouder - kind --- Hechting (psychologie) --- Baby --- Adoptiegezin --- Pleeggezin --- Prematuur (geboorte) --- Hechtingsprobleem --- Ontwikkelingspsychologie ; baby's
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Plants have evolved with a complex array of signaling molecules to facilitate their growth and development and their interactions with the environment. A vast number of different peptide molecules form an important but until recently often overlooked component amongst these signaling molecules. Plant peptide signals are involved in regulating meristem growth and organogenesis, modulating plant growth and homeostatic responses. They also have important roles as signals of imminent danger or pathogen attack. This volume focuses on the roles of various peptide signaling molecules in development, defence and homeostasis. As it is likely that further plant peptide signaling molecules remain to be discovered, the last section takes a practical look at methods to identify new peptides and characterise their functions.
Chemical structure --- Plant physiology. Plant biophysics --- Botany --- Pharmacology. Therapy --- Biochemical engineering --- systematische plantkunde --- moleculaire structuur --- protein-ligand binding constant --- protein-engineering --- farmacologie --- biochemie --- eiwitten --- planten --- moleculaire biologie --- Signal Transduction. --- Plants. --- Plant Cells. --- Peptides. --- Plant cellular signal transduction --- Peptides --- Botanical chemistry --- Transduction du signal cellulaire chez les plantes --- Chimie végétale --- EPUB-LIV-FT LIVBIOLO LIVBIOMO LIVMEDEC SPRINGER-B
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reacties (chemische technologie) --- chemie --- atoomfysica --- redoxreacties --- bindingen (chemie) --- Didactics of chemistry --- Chemistry --- kinetica --- atoomstructuur --- elementen (chemie) --- fysicochemie --- periodiek systeem --- chemische structuur --- Physicochemistry --- fysica --- zuur-base reactie --- Chemie --- 541 --- 54 --- Periodiek systeem --- atoombouw --- chemie (scheikunde) --- chemisch evenwicht --- chemische bindingen --- chemische kinetica --- chemische reacties --- oefeningen --- thermochemie --- zuur-base reacties --- 540.1 --- Aluminium --- Atoom --- Atoomtheorie --- Bohr --- Chemische reacties --- Dalton --- Deeltjesmodel --- Elektrocardiogram --- Elektrolyse --- Elektronen --- Evenwicht --- Ionenbinding --- Katalyse --- Kinetica --- Kristallisatie --- Maagzuur --- Materie --- Metaalbinding --- Metalen --- Orbitaalmodel --- Redoxreacties --- Rutherford --- Scheikunde --- Zouten --- Zwavel --- Atomen --- Thermochemie --- scheikunde (ler) --- atoomtheorie --- chemische binding --- chemische reactie --- elektron --- elektronentechniek --- periodieke tabel --- ph --- redoxreactie --- scheikunde (chemie) --- zuur-basereactie --- Algemene chemie --- 541 Theoretical chemistry --- Theoretical chemistry --- chemie. scheikunde --- Inleidingen - Hand- en leerboeken Chemie --- Atoombouw --- Periodiek systeem der elementen --- Chemische bindingen --- Reactiemechanismen --- Secundair onderwijs --- Hoger onderwijs --- Chemische Binding --- Chemische reactie --- Redoxreactie --- Reactiemechanisme --- Grafische sector --- #BSCH: vak: wetenschappen --- #BSCH: vak: chemie
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