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Book
Cytopathology.
Author:
ISBN: 9780199533923 Year: 2011 Publisher: Oxford Oxford University Press


Book
Metro Revealed : Building Windows 8 Apps with HTML5 and JavaScript
Authors: ---
ISBN: 9781430244899 Year: 2012 Publisher: Berkeley CA Apress Imprint Apress

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Abstract

This 88-page primer unveils the key features of Microsoft's eagerly anticipated Windows 8 operating system. Windows 8 contains the revolutionary Metro application framework for building dynamic and responsive touch-enabled applications that target both desktops and mobile devices. With the official release of Windows 8 looming ever closer, experienced author Adam Freeman invites you to take a crash course in Metro development. Using HTML5 and JavaScript, he ensures you understand the changes that are being made to Windows development practices and puts you on the right course to creating innovative and elegant applications for this latest evolution of the world's most successful operating system.


Book
Cytologie en histologie
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ISBN: 9789463932363 9789089319876 Year: 2020 Publisher: Gent : Owl Press,

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Hoe zijn cellen opgebouwd en hoe functioneren ze los van elkaar of in een context van weefsels, organen of stelsels? Deze kennis is essentieel voor alle studenten die een opleiding volgen in het brede veld van de geneeskunde en gezondheidswetenschappen. Het eerste luik (cytologie) van dit boek focust op de verschillende delen van de cel: het celmembraan, cytoplasma en de celkern. Hoe zijn ze samengesteld en hoe functioneren ze? De auteur legt hierbij de nadruk op het functionele, want vanuit de functie kan op eenvoudige wijze de structuur en de interactie tussen cellen worden bepaald. In het tweede luik (histologie) worden de primaire weefsels onderzocht: epitheel, bind- en steunweefsel (met inbegrip van bindweefsel, kraakbeen, been en vetweefsel), spierweefsel en zenuwweefsel. Dit luik is essentieel als opstap naar de deelgebieden anatomie en fysiologie/fysiopathologie. Aan de hand van een didactisch verantwoorde opbouw enondersteunend beeldmateriaal wordt deze materie inzichtelijk gemaakt voor iedere student.


Book
Cytology : diagnostic principles and clinical correlates
Authors: ---
ISBN: 9781437719703 1437719708 9781416053293 1416053298 Year: 2009 Publisher: Philadelphia, PA : Saunders/Elsevier,

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Abstract

This new edition examines the latest diagnostic techniques for the interpretation of a complete range of cytological specimens. It is concise, yet covers all of the organ systems in which the procedure is used, with the number of pages devoted to each body site proportional to the clinical relevance of cytology for that site. Inside, you'll find new information on ductal lavage cytology and expanded coverage of FNA performance, keeping you current with the newest procedures. Over 700 full-color illustrations provide you with a real-life perspective of a full range of cytologic findings. Each c

Membrane microdomain signaling : lipid rafts in biology and medicine
Author:
ISBN: 9781588293541 1588293548 9781592598038 9786610358243 1280358246 159259803X Year: 2005 Publisher: Totowa, N.J. : Humana Press,

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Abstract

Lipid rafts-discrete regions in cell membranes that are rich in cholesterol and sphingolipids-are emerging not only as pivotal command and control centers for cellular signaling processes, but also as central to a wide array of human diseases, including immune disorders, diabetes, cardiovascular disease, and Alzheimer's disease. In Membrane Microdomain Signaling: Lipid Rafts in Biology and Medicine, multidisciplinary experts offer cutting-edge reviews of our current understanding of these membrane microdomains and their physiological and pathological roles. Here, readers will discover how lipid rafts change in cells over time and how they respond to various environmental signals, how cholesterol modulates the signaling function of lipid rafts, and how lipid rafts, the extracellular matrix, and the cell cytoskeleton structurally interact. Also described are the role of lipid rafts in learning, memory, and cancer, and as portals for endocytic uptake of an anticancer- and apoptotic alkyl-lysophospholipid. The authors also present emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and that alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. They also describe techniques for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts. Comprehensive and insightful, Membrane Microdomain Signaling: Lipid Rafts in Biology and Medicine offers researchers a multidisciplinary review of the latest basic, translational, and clinical research that promises to transform our understanding microdomain signaling mechanisms.

Death receptors in cancer therapy
Author:
ISBN: 9781588291721 1588291723 9781592598519 9786610358199 128035819X 159259851X Year: 2005 Publisher: Totowa, N.J. : Humana Press,

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Abstract

Cell death, or apoptosis, plays an important role in biological processes and disease and offers special opportunities to develop new therapies for cancer, autoimmune disease, stroke, heart attack, and Alzheimer's disease. In Death Receptors in Cancer Therapy, leading physician-scientists and basic researchers review in depth our latest understanding of the molecular events that regulate cell death, illuminating those molecules that provide targets for agonists or antagonists designed to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particlar interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands. Authoritative and up-to-date, Death Receptors in Cancer Therapy offers a timely compendium of cell death signaling pathways for those seeking either a basic understanding of apoptosis or the knowledge needed to develop new therapeutics that will activate or block death signaling in disease.

Keywords

Neoplasms --- Cell Death --- Gene Therapy --- Receptors, Tumor Necrosis Factor --- Apoptosis --- Cell receptors --- Cancer --- Cellular signal transduction --- Apoptose --- Récepteurs cellulaires --- Transduction du signal cellulaire --- immunology --- therapy --- methods --- Molecular aspects --- Aspect moléculaire --- Kanker --- Kanker ; moleculaire aspecten --- Apoptosis. --- Cancer -- Molecular aspects. --- Cell receptors. --- Cellular signal transduction. --- Biological Therapy --- Genetic Engineering --- Diseases --- Investigative Techniques --- Cell Physiological Processes --- Receptors, Cytokine --- Cell Physiological Phenomena --- Receptors, Immunologic --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Genetic Techniques --- Therapeutics --- Receptors, Cell Surface --- Phenomena and Processes --- Membrane Proteins --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Methods --- Medicine --- Biology --- Health & Biological Sciences --- Cytology --- Oncology --- Molecular aspects. --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Medicine. --- Oncology. --- Medicine & Public Health. --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Binding sites (Biochemistry) --- Cell membranes --- Cell death

Molecular Parameters Indicating Adaptation to Mechanical Stress in Fibrous Connective Tissue
Authors: --- ---
ISSN: 03015556 00711098 ISBN: 9783540278320 9783540244745 3540244743 9786610306343 1280306343 354027832X Year: 2005 Volume: Bd. 1-22 Bd. 23-31 Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer,

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Abstract

The present study pursues the hypothesis that local compressive force and the occurrence of cartilage-specific transformation processes within tendons and ligaments are directly correlated. In selected anatomical samples of human origin the distribution pattern of certain components of the extracellular matrix is assessed. Investigations are carried out at the extensor tendons of toes and fingers, at the transverse ligament of the atlas, at the transverse ligament of the acetabulum, and at the tendon of the superior oblique muscle and its trochlea. The molecular components of the extracellular matrix are detected with standardized immunohistochemical methods. The results show that certain molecules only occur due to compressive stress, others due to tensile stress. The molecular spectrum of the extracellular matrix allows qualifying conclusions to the mechanical situation of a given part of the tissue. The spatial expansion of the fibrocartilaginous adaptation zones in tendons and ligaments roughly corresponds with the zones subjected to compressive force; tensile stress alone does not result in a production of fibrocartilage.


Book
The Golgi Apparatus : State of the art 110 years after Camillo Golgi's discovery
Authors: ---
ISBN: 9783211763100 3211763090 9783211763094 9786612036576 1282036572 3211763104 Year: 2008 Publisher: Vienna : Springer Vienna : Imprint: Springer,

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The Golgi apparatus is more than 110 years in the center of interest and scientific debates. This book summarizes the data obtained after development of methods of Golgi complex sub fractionation, molecular biology and microscopy collecting a range of expertise, different points of view and different approaches.


Book
Cellular automata and groups
Authors: ---
ISBN: 9783642140341 9783642140334 Year: 2010 Publisher: Heidelberg ; New York : Springer,

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Cellular automata were introduced in the first half of the last century by John von Neumann who used them as theoretical models for self-reproducing machines. The authors present a self-contained exposition of the theory of cellular automata on groups and explore its deep connections with recent developments in geometric group theory, symbolic dynamics, and other branches of mathematics and theoretical computer science. The topics treated include in particular the Garden of Eden theorem for amenable groups, and the Gromov-Weiss surjunctivity theorem as well as the solution of the Kaplansky conjecture on the stable finiteness of group rings for sofic groups. The volume is entirely self-contained, with 10 appendices and more than 300 exercises, and appeals to a large audience including specialists as well as newcomers in the field. It provides a comprehensive account of recent progress in the theory of cellular automata based on the interplay between amenability, geometric and combinatorial group theory, symbolic dynamics and the algebraic theory of group rings which are treated here for the first time in book form.


Book
Signaling in the heart
Authors: --- ---
ISBN: 9781441994615 9781441994608 Year: 2011 Publisher: New York : Springer,

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Abstract

Signal transduction pathways are at the core of most biological processes and are critical regulators of heart physiology and pathophysiology. The heart is both a transmitter and dynamic receptor of a variety of intracellular and extracellular stimuli, playing a critical role of an integrator of diverse signaling mechanisms. Alterations in signaling pathways are contributing factors in the development and progression of a broad spectrum of diseases, ranging from dysrhythmias and atherosclerosis to hypertension and the metabolic syndrome. Targeting specific components of these signaling pathways has been shown to be effective in preclinical studies with significant therapeutic impact.

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