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The birth of a baby with ambiguous genitalia triggers a chain reaction of difficulties that rapidly spread to the entire family and most medical attendants, leading to lasting effects on the gender identity, personality, and sexual functioning of the unfortunate individual. The rapid advances in medicine over the last 50 years have totally changed the outlook for children with disorders of sex development (DSD), but there is still much to learn. This book crystallizes the combined experience of a leading dedicated unit over 25 years in delivering expert medical and surgical care to children with DSD in a holistic environment. It documents the most recent advances in the molecular biology and embryology of sex development, and describes each disorder in detail. The clinical presentation and approach to diagnosis are described both for babies and for children presenting later in childhood or at adolescence. The chapters on management highlight all the latest knowledge and include the shared wisdom of the authors on current controversies, such as the timing of surgical treatment. Finally, the authors describe their short-, medium-, and long-term outcomes, which demonstrate the strengths of holistic team management.
genetica --- Human genetics --- medische genetica --- pediatrie --- Paediatrics --- Disorders of Sex Development. --- Sex differentiation disorders --- Sexual disorders. --- Différenciation sexuelle --- Troubles sexuels --- Anomalies --- EPUB-LIV-FT LIVMEDEC SPRINGER-B
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Plant cells house highly dynamic cytoskeletal networks of microtubules and actin microfilaments. They constantly undergo remodeling to fulfill their roles in supporting cell division, enlargement, and differentiation. Following early studies on structural aspects of the networks, recent breakthroughs have connected them with more and more intracellular events essential for plant growth and development. Advanced technologies in cell biology (live-cell imaging in particular), molecular genetics, genomics, and proteomics have revolutionized this field of study. Stories summarized in this book may inspire enthusiastic scientists to pursue new directions toward understanding functions of the plant cytoskeleton. The Plant Cytoskeleton is divided into three sections: 1) Molecular Basis of the Plant Cytoskeleton; 2) Cytoskeletal Reorganization in Plant Cell Division; and 3) The Cytoskeleton in Plant Growth and Development. This book is aimed at serving as a resource for anyone who wishes to learn about the plant cytoskeleton beyond ordinary textbooks. Bo Liu is professor in the Department of Plant Biology at the University of California in Davis, California. He received his B.S. degree in cell biology and genetics and M.S. degree in cell biology from Peking University in Beijing, China, and Ph.D. degree in botany from the University of Georgia in Athens, Georgia. Research in his laboratory is focused on studying the cytoskeletal basis of intracellular motility in flowering plants and filamentous fungi.
Plant physiology. Plant biophysics --- Botany --- systematische plantkunde --- planten --- Plant cytoskeleton --- Plant cell development --- Plant cell differentiation --- Plantes --- Cytosquelette --- Cellules et tissus --- Développement --- Différenciation --- EPUB-LIV-FT LIVBIOLO LIVBIOMO LIVMEDEC SPRINGER-B
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Cell biologists have recently become aware that the asymmetry of cell division is an important regulatory phenomenon in the fate of a cell. During development, cell diversity originates through asymmetry; in the adult organism asymmetric divisions regulate the stem cell reservoir and are a source of the drift that contributes to the aging of organisms with renewable cell compartments. Because of the concept of semi-conservative DNA synthesis, it was thought that the distribution of DNA between daughter cells was symmetric. The analysis of the phenomenon in cells during mitosis, however, revealed the asymmetry in the distribution of the genetic material that creates the drift contributing to aging of mammals. On the other hand, cancer cells can originate from a deregulation of asymmetry during mitosis in particular during stem cell expansion. The book describes the phenomenon in different organisms from plants to animals and addresses its implications for the development of the organism, cell differentiation, human aging and the biology of cancers.
embryologie (geneeskunde) --- histologie --- Histology. Cytology --- Oncology. Neoplasms --- General embryology. Developmental biology --- oncologie --- cytologie --- Cell division --- Cell differentiation --- Genetic recombination --- Symmetry (Biology) --- Biodiversity --- Cellules --- Recombinaison génétique --- Molecular aspects --- Genetic aspects --- Division --- Life Sciences --- Biology --- Molecular biology --- Biologie moléculaire --- Biologie moléculaire --- MDBIOCHE --- Cell differentiation. --- Cell division. --- Developmental biology. --- Cytology. --- Oncology. --- Developmental Biology. --- Cell Biology. --- Cancer Research. --- Tumors --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Development (Biology) --- Growth --- Ontogeny --- Cell biology. --- Cancer research. --- Cancer research
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Universal Design for Learning is de beste manier om efficiënt aan alle leerlingen les te geven. Maar hoe begin je met UDL? Je hebt het als leerkracht immers al druk genoeg. De antwoorden vind je in dit verhelderendeboek van de hand van Loui Lord Nelson, een ervaren leerkracht en gewezen UDL-coördinator. Leerkrachten uit het basis- en secundair onderwijs leren hoe ze de drie kernprincipes van UDL - Betrokkenheid, Representatie en Actie & Expressie - kunnen aanwenden om informatie op verschillende manieren aan te bieden. Zo komen ze met praktische tips, voorbeeldopdrachten, ideeën voor klasactiviteiten en gedetailleerde richtlijnen voor lesplanning, tegemoet aan de leernoden van de meest diverse leerlingen. Jongeren scherpen dankzij UDL hun executieve functievaardigheden aan, zoals het stellen van doelen en het ontwikkelen van strategieën. Ze verwerven meer inzicht, verwerken informatie beter en blijven betrokken bij de les. UDL leert leerlingen doeltreffender communiceren en vaardiger worden op het vlak van zelfregulatie en zelfbeoordeling. Ze leren ook doorzetten en zelfstandiger werken. Via flexibele taken en toetsen op maat tonen leerlingen wat ze kennen en kunnen.
Teaching --- didactiek --- onderwijspraktijk --- Didactiek --- Lesvoorbereidingen --- Executieve functies --- 454.2 --- Didactische principes --- Onderwijsstrategieën --- Lesgeven --- leeromgeving --- Leerprocessen --- onderwijsstrategieën --- leerprocessen --- Differentiation (Education) --- Enseignement individualisé --- Enseignement non sexiste --- Geïndividualiseerd onderwijs --- Inclusive education --- Individual instruction --- Individualized instruction --- Niet-seksistische onderwijs --- Onderwijs [Geïndividualiseerd ] --- Onderwijs op maat --- Pédagogie différenciée --- Onderwijskunde --- Leerdoelen --- 700 Pedagogie --- 454.3 --- Lesvoorbereiding
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Hierarchical matrices are an efficient framework for large-scale fully populated matrices arising, e.g., from the finite element discretization of solution operators of elliptic boundary value problems. In addition to storing such matrices, approximations of the usual matrix operations can be computed with logarithmic-linear complexity, which can be exploited to setup approximate preconditioners in an efficient and convenient way. Besides the algorithmic aspects of hierarchical matrices, the main aim of this book is to present their theoretical background. The book contains the existing approximation theory for elliptic problems including partial differential operators with nonsmooth coefficients. Furthermore, it presents in full detail the adaptive cross approximation method for the efficient treatment of integral operators with non-local kernel functions.The theory is supported by many numerical experiments from real applications.
Numerical analysis --- Computer. Automation --- informatica --- numerieke analyse --- differentiaalvergelijkingen --- wiskunde --- Partial differential equations --- Boundary value problems --- Differential equations, Elliptic --- Matrices --- 519.61 --- 519.63 --- 681.3*G14 --- 681.3 *G18 --- Algebra, Matrix --- Cracovians (Mathematics) --- Matrix algebra --- Matrixes (Algebra) --- Algebra, Abstract --- Algebra, Universal --- Elliptic differential equations --- Elliptic partial differential equations --- Linear elliptic differential equations --- Differential equations, Linear --- Differential equations, Partial --- Boundary conditions (Differential equations) --- Differential equations --- Functions of complex variables --- Mathematical physics --- Initial value problems --- 681.3 *G18 Partial differential equations: difference methods; elliptic equations; finite element methods; hyperbolic equations; method of lines; parabolic equations (Numerical analysis) --- Partial differential equations: difference methods; elliptic equations; finite element methods; hyperbolic equations; method of lines; parabolic equations (Numerical analysis) --- 681.3*G14 Quadrature and numerical differentiation: adaptive quadrature; equal intervalintegration; error analysis; finite difference methods; gaussian quadrature; iterated methods; multiple quadrature --- Quadrature and numerical differentiation: adaptive quadrature; equal intervalintegration; error analysis; finite difference methods; gaussian quadrature; iterated methods; multiple quadrature --- 519.61 Numerical methods of algebra --- Numerical methods of algebra --- 519.63 Numerical methods for solution of partial differential equations --- Numerical methods for solution of partial differential equations
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Hematopoietic Stem Cells brings together articles covering the biology of hematopoietic stem cells during embryonic development, reporting particular aspects of fly, fish, avian and mammalian models. Thus, this book allows a comparative overview of hematopoietic stem cell generation in the different classes, emphasizing the conserved trends in development. This book culminates with state-of –the art knowledge on hematopoietic development in human species and discussions of the most recent breakthroughs with relevance to both researchers and clinicians.
Biomedicine. --- Biomedicine general. --- Human Genetics. --- Cell Biology. --- Developmental Biology. --- Medicine. --- Human genetics. --- Cytology. --- Developmental biology. --- Médecine --- Génétique humaine --- Cytologie --- Biologie du développement --- Hematopoiesis -- physiology. --- Hematopoiesis. --- Hematopoietic Stem Cells -- physiology. --- Hematopoietic stem cells. --- Hematopoietic stem cells --- Hematopoiesis --- Bone Marrow Cells --- Cell Differentiation --- Blood Physiological Processes --- Biology --- Biological Science Disciplines --- Stem Cells --- Genetics --- Hematopoietic Stem Cells --- Physiology --- Blood Physiological Phenomena --- Hematopoietic System --- Cells --- Natural Science Disciplines --- Cell Physiological Processes --- Disciplines and Occupations --- Anatomy --- Hemic and Immune Systems --- Circulatory and Respiratory Physiological Phenomena --- Cell Physiological Phenomena --- Phenomena and Processes --- Human Anatomy & Physiology --- Health & Biological Sciences --- Blood formation --- Hemopoiesis --- HSCs (Hematopoietic stem cells) --- Human physiology. --- Cell biology. --- Human Physiology. --- Blood --- Blood cells --- Bone marrow cells --- Hematopoietic system --- Multipotent stem cells
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Since publication of the first edition of Volume I in 1994, the field of fungal biology has developed tremendously, mainly through the advancement of various molecular techniques and international fungal genome projects. To accommodate these developments, the second edition has been completely updated. Six chapters have been revised by former authors, others by newly recruited experts, and also novel subjects, emerged in more recent years, have been added to the book. Leading scientists in the field have compiled comprehensive overviews as well as latest results obtained from cytological, genetic and molecular studies. Topics include: cellular and colony growth of fungi, cellular fusion and incompatibility, senescence and programmed cell death, environmental and physiological signalling in differentiation processes, asexual and sexual reproduction, mitosis and meiosis of various types of fungi. Both parallels and differences become visible between individual fungi as well as between fungal classes.
Fungi. --- Mycology --- Mycology. --- Research. --- 582.28 --- 575 --- 66.098 --- 66.098 Biological processes. Biotechnology --- Biological processes. Biotechnology --- 575 General genetics. General cytogenetics. Immunogenetics. Evolution. Speciation. Phylogeny --- General genetics. General cytogenetics. Immunogenetics. Evolution. Speciation. Phylogeny --- 582.28 Eumycetes. True fungi. Moulds. Mycology --- Eumycetes. True fungi. Moulds. Mycology --- Science --- Science research --- Scientific research --- Information services --- Learning and scholarship --- Methodology --- Research teams --- Botany --- Fungi --- Microbiology --- Fungal kingdom --- Fungus kingdom --- Funguses --- Mycobiota --- Mycota --- Cryptogams --- Research --- Microbiology. --- Biotechnology. --- Microbial genetics. --- Microbial genomics. --- Plant genetics. --- Applied Microbiology. --- Microbial Genetics and Genomics. --- Plant Genetics and Genomics. --- Plants --- Genetics --- Genomics --- Microbial genetics --- Microorganisms --- Chemical engineering --- Genetic engineering --- Microbial biology --- Biology --- Mycology - Research --- -Research --- Fungal biology --- Fungology --- Fungus biology --- FUNGI --- SEXUALITY --- TREATISES --- GROWTH --- DIFFERENTIATION --- GENETICS --- BIOTECHNOLOGY --- MYCOLOGY --- RELATIONSHIPS
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The scientific study of sexual identity has made great strides in the five decades since Kinsey’s early investigations.; We know that sexual orientation exists on a continuum and not within a list of static categories such as "straight" and "gay", yet it’s not always clear what should be measured, or what should "count." It’s understood that sexual orientation is an intricate blend of sexual attraction, behavior, and identity, but it can also be informed by political identity, social behavior, and nuances of attraction that may possibly transcend sex. However one defines sexuality, Contemporary Perspectives on Lesbian, Gay, and Bisexual Identities relates these concepts to larger societal issues while also highlighting critical grey areas in the knowledge base, from the psychobiology of desire to the fluidity of adolescent sexual experience and self-expression. Well-known scholars in the psychology of sexual orientation: Explore the challenges of answering the basic question "How many gays are there?" when scholars, statisticians, and research participants widely disagree. Set out a cogent framework for understanding the degrees of sexual prejudice and stigma, motivation for hate crimes, and their effects on sexual minorities. Review the state of research on same-sex relationships as a work in progress. Report on the evolving legal status of gays and lesbians, as more same-sex couples consider adoption and lobby to change the marriage laws. Present current findings on children raised in same-sex households, from behavioral health to social relationships Raise the pertinent question—given the disparities between men and women in terms of sexual expression and arousal—"What is sexual orientation, and how do we view it through the lens of gender Contemporary Perspectives on Lesbian, Gay, and Bisexual Identities is especially timely during this current crossroads of social and political acceptance, and is thought-provoking, influential reading for researchers, practitioners working with sexual minorities, and policymakers. About the Nebraska Symposium on Motivation The Nebraska Symposium on Motivation has been sponsored by the Department of Psychology at the University of Nebraska-Lincoln since 1953. Each year the Symposium invites leading scholars from around the world to speak at a conference devoted to a topic of current interest to psychology, the proceedings of which are published in an edited volume.
519.1 --- 519.1 Combinatorics. Graph theory --- Combinatorics. Graph theory --- Combinatorial analysis --- Congresses. --- Consciousness. --- Sexual behavior. --- Psychology, clinical. --- Developmental psychology. --- Personality and Social Psychology. --- Sexual Behavior. --- Clinical Psychology. --- Gender Studies. --- Development (Psychology) --- Developmental psychobiology --- Psychology --- Life cycle, Human --- Apperception --- Mind and body --- Perception --- Philosophy --- Spirit --- Self --- Biochemical genetics --- Genetic regulation --- Algebra, Boolean --- Génétique biochimique --- Régulation génétique --- Algèbre de Boole --- Congresses --- Mathematical models --- Congrès --- Modèles mathématiques --- Personality. --- Social psychology. --- Sexual psychology. --- Clinical psychology. --- Sex (Psychology). --- Gender expression. --- Expression, Gender --- Sex (Psychology) --- Sex role --- Psychology, Sexual --- Sex --- Sexual behavior, Psychology of --- Sexual psychology --- Sensuality --- Psychiatry --- Psychology, Applied --- Psychological tests --- Mass psychology --- Psychology, Social --- Human ecology --- Social groups --- Sociology --- Personal identity --- Personality psychology --- Personality theory --- Personality traits --- Personology --- Traits, Personality --- Individuality --- Persons --- Temperament --- Psychological aspects --- Analyse combinatoire --- Motivation --- Bisexual identities --- Lesbian identities --- Homosexuels masculins - Identité - Congrès --- Lesbiennes - Identité - Congrès --- Bisexuels - Congrès --- Homosexuels - Psychologie - Congrès --- Bisexuels - Psychologie - Congrès --- Difference (Psychology). --- Sex. --- Personality and Differential Psychology. --- Psychology of Gender and Sexuality. --- Gender (Sex) --- Human beings --- Human sexuality --- Sex (Gender) --- Sexual behavior --- Sexual practices --- Sexuality --- Sexology --- Differential psychology --- Psychology, Differential --- Differentiation (Developmental psychology)
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