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evidence-based verpleegkunde --- vroedkunde --- 614.7 --- Vroedkunde --- Bevalling --- vroedvrouwen --- bevalling --- bevallingswijzen --- Physiology: reproduction & development. Ages of life --- Gynaecology. Obstetrics --- geboorte --- Verloskunde --- Gynaecologie --- Midwifery --- Evidence-based medicine --- Childbirth --- Labor (Obstetrics) --- Birth --- Obstetric labor --- Obstetrics --- Pregnancy --- Delivery (Obstetrics) --- EBM (Medicine) --- Evidence-based healthcare --- Clinical medicine --- Systematic reviews (Medical research) --- Birthing --- Child birth --- Live birth --- Parturition --- Decision making

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Randomized clinical trials are the gold standard for establishing many clinical practice guidelines and are central to evidence based medicine. Obtaining the best evidence through clinical trials must be done within the boundaries of rigorous science and ethical principles. One fundamental principle is that trials should not continue longer than necessary to reach their objectives. Therefore, trials must be monitored for recruitment progress, quality of data, adherence to patient care or prevention standards, and early evidence of benefit or harm. Frequently, a group of external experts, independent from the investigators and trial sponsor, is charged with this monitoring responsibility, especially for safety and early benefit. This group is referred to by various names, such as a data monitoring committee or a data and safety monitoring board. This book, through a series of case studies presented by many distinguished clinical trial experts, illustrates the complexity of this monitoring process. The editors provide an overview of the process and a summary of a multitude of the lessons learned from the cases presented. This book should be useful to anyone serving on a data and safety monitoring board, or planning to do so, for colleagues in academia, industry and governmental agencies, and for teaching students in biostatistics, epidemiology, clinical trials and medical ethics. No other text has as extensive a collection of cases which provide insight into the many issues, often conflicting, that must be examined before recommendations to continue or discontinue a trial can be made. While depth in statistical methods is not required, some familiarity with statistical design and analysis issues in clinical trials is helpful. The cases cover trials which were terminated early for convincing evidence of benefit, or for harmful effects. Cases with complex issues are also included. This series of cases should provide broad background information for potential monitoring committee members and better prepare them for the challenges that may exist in the trials for which they are responsible. The three editors have contributed two overview chapters as well as several case studies to go along with cases contributed by a distinguished group of colleagues experienced in the design, monitoring and analysis of clinical trials. Dr. David DeMets is currently Professor and Chair, Department of Biostatistics and Medical Informatics at the University of Wisconsin-Madison. He is past president of the Eastern North American Region (ENAR) of the International Biometric Society, a past member of the Board of Directors of the American Statistical Association and an elected Fellow. He recently received the Robert Gordon Lectureship Award, given by the National Institutes of Health, for significant contributions to the field of clinical trials. Dr. Curt Furberg, is currently Professor (and former Chair) of the Department of Public Health Sciences at Wake Forest University. Previously, he was Head of the Clinical Trials Branch and Associate Director of the Clinical Applications and Prevention Program at the National Heart, Lung, and Blood Institute. Dr. Lawrence Friedman is a former Director of the Division of Epidemiology and Clinical Applications and a former Assistant Director for Ethics and Clinical Research at the National Heart, Lung, and Blood Institute. All three are past presidents of the Society of Clinical Trials. The editors have collaborated previously as coauthors of a text: the Fundamentals of Clinical Trials.

Biomathematics. Biometry. Biostatistics --- medische statistiek --- biostatistiek --- Clinical Trials --- Automatic Data Processing. --- Clinical trials --- Etudes cliniques --- Case Reports. --- Data processing. --- Case studies. --- Informatique --- Cas, Etudes de --- Clinical trials - Data processing. --- Controlled Clinical Trials as Topic --- Research --- Professional Staff Committees --- Clinical Trials as Topic --- Quality Assurance, Health Care --- Science --- Natural Science Disciplines --- Health Care Quality, Access, and Evaluation --- Epidemiologic Study Characteristics as Topic --- Evaluation Studies as Topic --- Health Care --- Epidemiologic Methods --- Disciplines and Occupations --- Health Care Evaluation Mechanisms --- Investigative Techniques --- Quality of Health Care --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Public Health --- Environment and Public Health --- Randomized Controlled Trials as Topic --- Biomedical Research --- Clinical Trials Data Monitoring Committees --- Mathematics --- Medicine --- Physical Sciences & Mathematics --- Health & Biological Sciences --- Mathematical Statistics --- Medical Research --- Data processing --- Statistics. --- Statistics for Life Sciences, Medicine, Health Sciences. --- Statistical analysis --- Statistical data --- Statistical methods --- Statistical science --- Econometrics --- Statistics .

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Complement has long been regarded as a pivotal effector arm of the innate immune response, eliciting important immunoregulatory functions in the context of inflammation and also serving as a vital link between the innate and adaptive immune response. In the post-genomic era, our knowledge of the innate immune system is enriched by findings that point to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or Inflammation. Several studies indicate that complement proteins exert functions that are either more complex than previously thought, or go well beyond the innate immune character of the system. The advent of high-throughput platforms for genome and proteome-wide profiling, together with the enormous amount of raw genetic information that has accumulated in the databases, have stirred new expectations in biomedical research. They have led complementologists to revisit established biological systems, such as the complement system, from a global and integrative perspective. Complement research is now faced with the challenge of trying to integrate isolated biochemical pathways into complex gene and protein regulatory circuits. In this respect, scientists from around the world convened at the Fourth Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 10-15, 2007), to discuss recent advances in this fast evolving field. This volume represents a collection of topics on the “novel” functions of complement, patho-physiology, protein structures, design of complement inhibitors, and complement assays discussed during the conference.

Biomedicine. --- Immunology. --- Microbiology. --- Infectious Diseases. --- Pathology. --- Medicine. --- Emerging infectious diseases. --- Médecine --- Immunologie --- Maladies infectieuses émergentes --- Pathologie --- Microbiologie --- Complement (Immunology) -- Congresses. --- Complement (Immunology). --- Complement (Immunology) --- Immunoproteins --- Immune System Processes --- Publication Formats --- Blood Proteins --- Publication Characteristics --- Immune System Phenomena --- Proteins --- Phenomena and Processes --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Complement System Proteins --- Congresses --- Complement Activation --- Medicine --- Biology --- Health & Biological Sciences --- Medical Research --- Microbiology & Immunology --- Natural immunity --- Disease resistance --- Host resistance --- Innate immunity --- Innate resistance --- Native immunity --- Natural resistance --- Nonspecific immunity --- Resistance to disease --- Alexin --- Complements (Immunity) --- Infectious diseases. --- Microbial biology --- Microorganisms --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Pathology --- Physicians --- Immunity --- Blood proteins --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases