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Periodical
Lab animal
ISSN: 00937355 Publisher: New York, N.Y.

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Periodical
Pharmaceutisch Weekblad
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ISSN: 00316911 Year: 1864 Publisher: : The Hague,

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Periodical
AWHONN lifelines.
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ISSN: 10915923 15526356 Year: 1997 Publisher: Philadelphia Lippincott-Raven.

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Multi
Localization and distribution of estrogen receptors and progesterone receptors in the bovine ovary in relation to the cell dynamics
Authors: ---
ISBN: 9058640973 Year: 2006

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Book
Statistique : la théorie et ses applications
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ISSN: 17685656 ISBN: 9782817801575 9782817801568 2817801563 Year: 2010 Publisher: Paris: Springer,

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Cet ouvrage expose les fondements théoriques des méthodes classiques de la statistique (estimation et tests) ainsi que des approches introduites plus récemment. Les premiers chapitres sont consacrés aux notions de la théorie des probabilités, nécessaires à la statistique. Puis sont développés les tests et méthodes d'estimation dans les situations paramétriques et non paramétriques. Les modèles de base de la régression sont traités en fin d'ouvrage. Chaque chapitre est accompagné d'exemples concrets, mais aussi d'exercices - plus de 150 au total - dont les corrigés ont été intégrés dans cette deuxième édition. La présentation témoigne d'un réel souci pédagogique de l'auteur qui bénéficie d'une vaste expérience d'enseignement auprès de publics très variés. Les résultats exposés sont, autant que possible, replacés dans la perspective de leur utilité pratique. Le niveau mathématique requis rend ce livre accessible aux étudiants de premier cycle universitaire et aux chercheurs dans les divers domaines des sciences appliquées. Il sera donc utile aux étudiants devant aborder les aspects théoriques de la statistique ou aux utilisateurs, pour les assurer du choix judicieux des méthodes qu'ils emploient.


Book
Targeted Learning : Causal Inference for Observational and Experimental Data
Authors: ---
ISBN: 9781441997821 1441997814 9783030097363 9781441997814 1441997822 3030097366 Year: 2011 Publisher: New York, NY : Springer New York : Imprint: Springer,

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The statistics profession is at a unique point in history. The need for valid statistical tools is greater than ever; data sets are massive, often measuring hundreds of thousands of measurements for a single subject. The field is ready to move towards clear objective benchmarks under which tools can be evaluated. Targeted learning allows (1) the full generalization and utilization of cross-validation as an estimator selection tool so that the subjective choices made by humans are now made by the machine, and (2) targeting the fitting of the probability distribution of the data toward the target parameter representing the scientific question of interest.   This book is aimed at both statisticians and applied researchers interested in causal inference and general effect estimation for observational and experimental data. Part I is an accessible introduction to super learning and the targeted maximum likelihood estimator, including related concepts necessary to understand and apply these methods. Parts II-IX handle complex data structures and topics applied researchers will immediately recognize from their own research, including time-to-event outcomes, direct and indirect effects, positivity violations, case-control studies, censored data, longitudinal data, and genomic studies. "Targeted Learning, by Mark J. van der Laan and Sherri Rose, fills a much needed gap in statistical and causal inference. It protects us from wasting computational, analytical, and data resources on irrelevant aspects of a problem and teaches us how to focus on what is relevant – answering questions that researchers truly care about." -Judea Pearl, Computer Science Department, University of California, Los Angeles "In summary, this book should be on the shelf of every investigator who conducts observational research and randomized controlled trials. The concepts and methodology are foundational for causal inference and at the same time stay true to what the data at hand can say about the questions that motivate their collection." -Ira B. Tager, Division of Epidemiology, University of California, Berkeley.


Book
Fundamentals of clinical trials.
Authors: --- ---
ISBN: 9781441915863 9781441915856 1441915850 Year: 2010 Publisher: New York Springer Science & Business Media

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This is the fourth edition of a very successful textbook on clinical trials methodology, written by three recognized experts who have long and extensive experience in all areas of clinical trials. Most chapters have been revised considerably from the third edition. A chapter on ethics has been added and topics such as noninferiority and adaptive designs now receive considerable discussion. There is much new material on adverse events, adherence, data monitoring, and issues in analysis. This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of patients. The authors use numerous examples of published clinical trials from a variety of medical disciplines to illustrate the fundamentals. The text is organized sequentially from defining the question to trial closeout. One chapter is devoted to each of the critical areas to aid the clinical trial researcher. These areas include pre-specifying the scientific questions to be tested and appropriate outcome measures, determining the organizational structure, estimating an adequate sample size, specifying the randomization procedure, implementing the intervention and visit schedules for participant evaluation, establishing an interim data and safety monitoring plan, detailing the final analysis plan, and reporting the trial results according to the pre-specified objectives. Although a basic introductory statistics course is helpful in maximizing the benefit of this book, a researcher or practitioner with limited statistical background would still find most if not all the chapters understandable and helpful. While the technical material has been kept to a minimum, the statistician may still find the principles and fundamentals presented in this text useful. This book has been successfully used for teaching courses in clinical trial methodology.


Book
Applying Quantitative Bias Analysis to Epidemiologic Data
Authors: --- --- ---
ISBN: 9780387879598 9780387879604 0387879609 Year: 2009 Publisher: New York NY Springer New York

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This text provides the first-ever compilation of bias analysis methods for use with epidemiologic data. It guides the reader through the planning stages of bias analysis, including the design of validation studies and the collection of validity data from other sources. Three chapters present methods for corrections to address selection bias, uncontrolled confounding, and classification errors. Subsequent chapters extend these methods to multidimensional bias analysis, probabilistic bias analysis, and multiple bias analysis. The text concludes with a chapter on presentation and interpretation of bias analysis results. Although techniques for bias analysis have been available for decades, these methods are considered difficult to implement. This text not only gathers the methods into one cohesive and organized presentation, it also explains the methods in a consistent fashion and provides customizable spreadsheets to implement the solutions. By downloading the spreadsheets (available at links provided in the text), readers can follow the examples in the text and then modify the spreadsheet to complete their own bias analyses. Readers without experience using quantitative bias analysis will be able to design, implement, and understand bias analyses that address the major threats to the validity of epidemiologic research. More experienced analysts will value the compilation of bias analysis methods and links to software tools that facilitate their projects. Timothy L. Lash is an Associate Professor of Epidemiology and Matthew P. Fox is an Assistant Professor in the Center for International Health and Development, both at the Boston University School of Public Health. Aliza K. Fink is a Project Manager at Macro International in Bethesda, Maryland. Together they have organized and presented many day-long workshops on the methods of quantitative bias analysis. In addition, they have collaborated on many papers that developed methods of quantitative bias analysis or used the methods in the data analysis.

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