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5. 4. 2 Definitievanmedisch-wetenschappelijk onderzoekmetmensen 241 5. 4. 3 Eisenaanmedisch-wetenschappelijkonderzoek metmensen 245 5. 4. 4 Medisch-wetenschappelijkonderzoekmet wilsonbekwamen 261 5. 4. 5 Medisch-wetenschappelijkonderzoekmet personeninonvrijesituaties 269 5. 4. 6 Toezicht 271 5. 4. 7 Aansprakelijkheidenverzekering 275 5. 4. 8 Bijzonderebepalingenvoorgeneesmiddelen- derzoek 278 6 Orgaan-enweefseltransplantatie 283 6. 1 Inleiding 283 6. 2 Levendedonor 286 6. 3 Organenuitoverledenen 290 6. 3. 1 Beslissystemen 290 6. 3. 2 BeslissysteemWod 292 6. 4 Voorbereiding,orgaancentrumenorgaanbank 296 6. 5 Xenotransplantatie 298 6. 6 Internationaleaspecten 299 7 Medischekeuringen 303 7. 1 Inleiding 303 7. 2 Soortenkeuringen 306 7. 3 Bijdekeuringbetrokkenpartijen 308 7. 4 Inhoudkeuring 309 7. 5 Wetopdemedischekeuringen 310 7. 5. 1 Achtergrond 310 7. 5. 2 Overzicht 311 7. 5. 3 Algemenenormenvooraanstellings-enver- keringskeuringen 312 7. 5. 4 Aanstellingskeuring 314 7. 5. 5 Verzekeringskeuring 317 7. 5. 6 Zelfregulering 320 7. 5. 7 Rechtsbescherming 321 7. 5. 8 EvaluatieWmk 322 7. 6 Rechtenvandekeurling 323 7. 6. 1 Betekenisregelinggeneeskundigebehan- lingsovereenkomst 323 7. 6. 2 Informatie,toestemmingengeheimhouding 323 7. 6. 3 Mededelingsplichtkeurling 325 7. 6. 4 Dossierrechten 327 Inhoud IX 7. 6. 5 Inzage-enblokkeringsrecht 329 7. 6. 6 Rapportageeninformatie-uitwisseling 330 7. 6. 7 Herkeuring 332 7. 7 Positievandekeurendarts 332 8 Preventie,gezondheidsbeschermingen-bev- dering 337 8. 1 Inleiding 337 8. 2 Wetcollectievepreventievolksgezondheid 340 8. 3 Infectieziekten 343 8. 4 Vaccinatie 348 8. 5 Bevolkingsonderzoek 351 9 Aansprakelijkheidenindividueleberoepsuit- fening 359 9. 1 Algemeen 359 9. 1. 1 Tuchtrecht 360 9. 1. 2 Maatregelenwegensongeschiktheid 361 9. 1. 3 Tuchtrechtelijkeprocedure 364 9. 1. 4 Opvallendekwesties 369 9. 1. 5 Evaluatierapportenrapportvandecommissie- Huls 385 9.

Medical law --- gezondheidsrecht --- Netherlands

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(Draft) In this volume the unique and common features of rhabdoviruses, particularly their morphological, molecular, and pathogenic characteristics, and their phylogenetic relationships are reviewed. Rhabdoviruses have a very wide host range and have been isolated from plants, insects, and almost from all vertebrates including fish and primates. The Rhabdoviridae family consists of six genera which have all been associated with diseases. While rhabdoviruses that are etiological agents of human diseases can cause serious public health problems, other members of this family that infect domestic livestock and agricultural plants can also cause enormous economic loss. .

Medical microbiology, virology, parasitology --- virologie

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The chapters in this volume provide an account of the present knowledge and understanding of Foot and Mouth disease virus pathogenesis and global epidemiology, the detailed structure of the virus itself and the properties of its RNA genome. Also considered are the immune response of the host and the state of the art in vaccine production, and the nature of virus evolution. It is clear that in all these areas there is still much more to learn about this fascinating virus. Because of its highly contagious nature research work on FMDV is restricted to a small number of laboratories worldwide that have adequate containment facilities. Despite this restriction, the recent progress in research on FMDV which is described in this volume has provided a remarkable level of understanding of this unique virus.

Medical microbiology, virology, parasitology --- virologie

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Reoviridae family members are large, complex viruses that infect human, animals, plants and insects. They are unique in that they lack lipid envelopes and package their genomes of discrete double-stranded segments of RNA within multi-layered capsids. Lack of a lipid envelope has allowed three-dimensional structures of these large complex viruses to be obtained. The capsids of these viruses undergo cell entry, uncoating, the enzymatic functions necessary for transcription of the genome, and are later involved in egress from host cells. Recent years have seen an increase in our knowledge of the structure of these viruses coupled with substantial progress in unravelling the molecular details of these processes. Intriguingly, despite their diversity in hosts, structures and modes of transmission, striking parallels have emerged in the molecular interactions necessary for the essential processes of virus entry, assembly and release. This book reviews our current understanding of Reoviridae entry, disassembly/assembly and egress in addition to updating high resolution structures of viral proteins and capsids from three different genera of the family.

Medical microbiology, virology, parasitology --- virologie

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The earliest observation of cytomegalovirus (CMV) interactions with the host cell was owl eye cytopathology in various tissues. It was recognized in the early 1970s that human CMV caused in utero infections resulting in congenital brain damage and other sensory neurological complications. Events of the 1980s and early 1990s, such as the wide application of solid organ and bone marrow transplantation and the emergence of AIDS, put the spotlight on human CMV. We understood that the virus was an opportunistic agent associated with immunosuppression. The golden age of cytomegalovirus research was ushered in during the late 1970s and early 1980s by a set of powerful new technologies that included restriction enzymes, DNA cloning, DNA sequencing, and open reading frame prediction. The genetic manipulation and propagation of novel CMV strains was accelerated with the app- cation of bacterial artificial chromosome technology. Today, we still struggle to understand the full spectrum of disease associated with human CMV. To the molecular biologist, CMV is a master of regulation in the eukaryotic cell where it either replicates or remains latent. To the immunologist, CMV is a master of immune evasion with tools to escape both the innate and acquired immune responses. The use of animal models with non-human CMVs has become significantly more sophisticated and tied to a more certain understanding of the interrelationships of non-human and human CMV genes.

Medical microbiology, virology, parasitology --- virologie