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In this book, we collected scientific articles, including reviews and research articles, showcasing the lastest literature on the importance of biochemical biomarkers in the management of neurodegenerative diseases, from screening to diagnosis, prognosis, and treatment.

GLUT3 --- cerebral ischemia --- MCAO --- resveratrol --- astrocytes --- AMPK --- amyotrophic lateral sclerosis --- GSK3β --- neurodegenerative disease --- PD --- Arylsulfatase A --- lysosomes --- GWAS --- Gaucher’s disease --- prognostic biomarker --- focused ultrasound --- MR-guided focused ultrasound --- high-intensity focused ultrasound ablation --- magnetic resonance imaging --- image quality --- stereotaxic techniques --- essential tremor --- Alzheimer’s disease --- amyloid precursor protein --- Tyr682 residue --- YENPTY motif --- Fyn tyrosine kinase --- amyloid beta --- ALS --- biomarker --- beta amyloid --- AD --- biomarkers --- SARS-CoV-2 --- neuroinflammation --- neurodegenerative nisease --- nervous system --- Alzheimer’s Disease --- Vitamin D --- 25(OH)D levels --- Vitamin D deficiency --- inherited neuromuscular disorders --- rare diseases --- multiple sclerosis --- genetic --- polymorphisms --- FOXP3 --- GATA3 --- vitamin D --- neuromelanin --- nigrosome-1 --- iron --- radiomics --- neurodegenerative diseases --- Parkinson’s disease --- parkinsonian disorders --- n/a --- Gaucher's disease --- Alzheimer's disease --- Alzheimer's Disease --- Parkinson's disease

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This compilation focuses on recent advances in the molecular and cellular understandingof neuromuscular biology, and the treatment of neuromuscular disease.These advances are at the forefront of modern molecular methodologies, oftenintegrating across wet-lab cell and tissue models, dry-lab computational approaches,and clinical studies. The continuing development and application ofmultiomics methods offer particular challenges and opportunities in the field,not least in the potential for personalized medicine.

LMNA --- Emery–Dreifuss muscular dystrophy --- Omics --- ALS --- MND --- ALS variants --- genotype–phenotype --- ALS genes --- FSHD --- DUX4 --- transcription --- muscle --- regulation --- spinal muscular atrophy --- adult patients --- disease heterogeneity --- Nusinersen --- disease modifiers --- functional outcomes --- biomarkers --- epigenetic changes --- -omics approaches --- oxidative stress --- mitochondria dysfunction --- axonal transport --- autophagy --- endocytosis --- secretion --- excitotoxicity --- RNA metabolism --- Duchenne muscular dystrophy (DMD) --- exon-skipping therapies --- next-generation sequencing (NGS) --- Sanger sequencing --- multiplex ligation probe amplification (MLPA) --- multiplex polymerase chain reaction (PCR) --- comparative genomic hybridization array (CGH) --- viltolarsen --- eteplirsen --- golodirsen --- rheumatoid arthritis --- SNP --- DMARD --- methotrexate --- pharmacogenomics --- Duchenne muscular dystrophy --- pharmacodynamic biomarkers --- prednisone --- deflazacort --- glucocorticoids --- corticosteroids --- safety --- neuromuscular diseases --- translational research --- disease models --- precision medicine --- miRNA --- proteomics --- calprotectin --- dystrophy --- Becker muscular dystrophy --- dystrophinopathy --- genotype-phenotype correlations --- Canadian Neuromuscular Disease Registry --- reading frame rule --- dystrophin --- multiple logistic regression analysis --- exon skipping therapy --- Amyotrophic Lateral Sclerosis --- machine learning --- genome-wide association studies --- GWAS --- genomics --- ALS pathology --- gene prioritization --- AAV --- genetic neuromuscular disorders --- gene therapy --- clinical trials --- toxicity --- SMA --- DMD --- XLMTM --- facioscapulohumeral dystrophy --- TALEN --- CRISPR-Cas9 --- gene editing --- polyadenylation --- D4Z4 --- duchenne muscular dystrophy (DMD) --- becker muscular dystrophy (BMD) --- exon skipping --- skip-equivalent deletions --- n/a --- Emery-Dreifuss muscular dystrophy --- genotype-phenotype