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Food products are very complex mixtures consisting of naturally occurring compounds and other substances, generally originating from technological processes, agrochemical treatments, or packaging materials. However, food is no longer just a biological necessity for survival. Society demands healthy and safe food, but it is also increasingly interested in other quality attributes more related to the origin of the food, the agricultural production processes used, the presence or not of functional compounds, etc. Improved methods for the determination of authenticity, standardization, and efficacy of nutritional properties in natural food products are required to guarantee their quality and for the growth and regulation of the market. Nowadays, liquid chromatography with ultraviolet detection, or coupled to mass spectrometry and high-resolution mass spectrometry, are among the most powerful techniques to address food safety issues and to guarantee food authenticity in order to prevent fraud. The aim of this book is to gather review articles and original research papers focused on the development of analytical techniques based on liquid chromatography for the analysis of food. This book is comprised of six valuable scientific contributions, including five original research manuscripts and one review article, dealing with the employment of liquid chromatography techniques for the characterization and analysis of feed and food, including fruits, extra virgin olive oils, confectionery oils, sparkling wines and soybeans.

confectionery fats --- positional isomers --- silver-ion HPLC --- triglycerides --- high performance liquid chromatography --- UV detection --- multivariate calibration --- food authentication --- olive oils --- fraud quantitation --- controlled environment --- far infrared irradiation (FIR) --- light emitting diode (LED) light --- flavonoid --- soybean sprouts --- food and feed analysis --- liquid chromatography --- challenges --- nutritional analysis --- additives --- contaminants --- polyphenols --- protected designation of origin --- coupages --- sparkling wine (cava) --- characterization --- chemometrics --- Passifloraceae --- Solanaceae --- hypoglycaemic --- α-amylase --- n/a

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The exploitation of biodiversity is essential to select resilient genotypes for sustainable cropping systems as one of the main challenges for plant breeding. Mapping traits of agronomic interest in specific genomic regions appears as another pivotal effort for the future development of novel cultivars. For this purpose, there is evidence that MAGIC and other exotic populations will play a major role in the coming years in allowing for impressive gains in plant breeding for developing new generations of improved cultivars. This Special Issue focused on the application of advanced technologies devoted to crop improvement and exploit the available biodiversity in crops. In detail, next-generation sequencing (NGS) technologies supported the development of high-density genotyping arrays for different plants included in this issue.

natural variation --- maize --- nucleotide diversity --- domestication selection --- ZmPGP1 gene --- Ipomoea batatas --- genetic diversity --- SSR markers --- qualitative traits --- pure lines --- F1 hybrids --- microsatellite markers --- marker-assisted breeding --- crop improvement --- varieties --- Fragaria --- Rubus --- microsatellites --- transferability --- polymorphism --- introns --- exons --- flavonoid biosynthesis pathway --- transcription factor genes --- chitinase --- multiple population --- linkage mapping --- JLAM --- QTL --- validation --- genomic prediction --- maize lethal necrosis --- herbaceous peony --- molecular marker --- next-generation sequencing --- pedigree --- Vicia faba L., genetic diversity --- in situ conservation --- Olea europaea L. --- olive --- cpSSR --- nuSSR --- population structure --- Mediterranean Region --- GWAS --- drought --- barley --- spikelet development --- candidate gene --- linkage map --- RAD --- Solanum melongena --- n/a

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This Special Issue provides recent advances in the use of plants for therapeutic purposes. This Special Issue collected the plants, including leaf, fruit, and others. This Special Issue's targets were crude plant extract and active principle purified from the plant. This Special Issue prompted researchers to provide each plant discovery. We are pleased to include in this Special Issue the screened Mexican plants and the halophytic plants growing in central Saudi Arabia, and so on. As a result, we have sparked scientists' interest in studying the plant for therapeutic purposes. This field necessitates network pharmacology analysis and machine-aided learning. Many disorders resistant to modern medication are looking for active principles isolated from the plants all over the world.

Medicine --- Pharmacology --- safflower --- hydroxysafflor yellow A --- safflower yellow A --- flavonoid --- platelet aggregation --- vescalagin --- methylglyoxal --- inflammation --- antioxidant --- insulin secretion --- traditional medicine --- hypoglycemic plants --- Eryngium longifolium --- Alsophila firma --- glucose 6-phosphatase --- fructose 1,6-bisphosphatase --- Lycium shawii --- Anabasis articulata --- Rumex vesicarius --- Zilla spinosa --- anticancer --- antimicrobial --- biogenetic interrelationship --- flavonoid contents --- trace elements --- human tumor cell lines --- cytotoxic effect --- plant extracts --- Acalypha monostachya --- Lindera obtusiloba --- apolipoprotein E-deficient mice --- atherosclerosis --- endothelium --- black bean soybean sauce --- by-product --- functional supplements --- Moringa oleifera --- anti-aging --- fibrosis --- kidney disease --- Gan-Mai-Da-Zao --- depression --- brain-derived neurotrophic factor --- serotonin transporter --- unpredictable chronic mild stress --- Acalypha arvensis --- ellagitannin --- corilagin --- Staphylococcus aureus --- flavonoids --- antibacterial --- Alzheimer’s disease --- amyloid β --- immunomagnetic reduction --- Drosophila melanogaster --- water extract of fermented rice bran --- non-alcoholic fatty liver disease --- high-fat diet --- aged rat --- Salvia haematodes --- rapid solid–liquid dynamic extraction (RSLDE) --- extractor Naviglio® --- Soxhlet apparatus --- medium pressure liquid chromatography (MPLC) --- antioxidant potential --- Inga jinicuil --- phytochemical profile --- HPLC-PDA --- GC-MS --- anti-inflammatory --- fast dissolving films --- yeast β-glucan --- bilberry juice --- diabetes --- herbal medicine --- bioactive derivative --- triple negative breast cancer --- Wnt/β-catenin --- anti-cancer --- n/a --- Alzheimer's disease --- rapid solid-liquid dynamic extraction (RSLDE)

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Lignans are a class of natural products found mainly in plants. They have a wide variety of structures and exhibit a range of potent biological activities. Lignans are also well-known components of a number of widely eaten foods and are frequently studied for their dietary impact. Owing to these factors, lignans have been extensively studied by scientists from a large number of disciplines. This collection of research and review articles describes topics ranging in scope from the recent isolation and structural elucidation of new lignans, strategies towards the chemical synthesis of lignans, assessment of their biological activities and potential for further therapeutic development. Research showing the impact of lignans in the food and agricultural industries is also presented.

taste-active compound --- heilaohu --- 9-norlignans --- antioxidant activity --- drug-like --- human health --- chemometrics --- lignan --- bitterness --- red-flowered Chinese magnolia vine --- antioxidant --- ruminant --- secoisolariciresinol diglucoside --- quantification --- intermolecular interactions --- cattle --- anti-inflammatory activity --- acyl-Claisen --- LOX --- seed --- food groups --- microtubules --- anti-proliferative --- acetylcholinesterase inhibitors --- flax --- arylnaphthalene lignan --- epiboly --- aryldihydronaphthalene lignan --- multiple bioactive components --- enterolignan --- total synthesis --- genetic --- synthesis --- cultivated --- cell cycle --- chronic diseases --- national databases --- oxidation --- chemical components --- molecular dynamics --- COX --- lignans --- hydroxycinnamic acid --- chemical structures --- Chinese magnolia vine --- stereoselective synthesis --- sPLA2 --- Bursera fagaroides --- in silico studies --- antibacterial activity --- semisynthesis --- dibenzyl butyrolactones --- flavonoid glycoside --- lignan glycoside --- chemical characterization --- hydroxymatairesinol --- podophyllotoxin --- Lespedeza cuneata --- Bursera --- oak ageing --- Schisandrae Chinensis Fructus --- F-actin --- cultivar --- UHPLC-MS/MS --- bioactivity --- podophyllotoxin-type lignans --- harmonized databases --- graph theory --- antioxidants --- health promotion --- simultaneous quantitation --- natural products --- dietary intake --- cell migration --- Lignan --- chemical space --- diet --- Lauraceae --- pharmacokinetic --- cytotoxicity --- tujia ethnomedicine --- flavonolignans --- flavonol --- adipocyte and osteoblast differentiation --- Burseraceae --- environment --- dietary lignans --- phytochemical analysis --- Schisandra chinensis --- animal health --- neolignans --- Schisandra rubriflora --- cancer --- norlignans --- wild

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Natural products are bioactive compounds synthesized by terrestrial and marine plants, microorganisms and animals, whose main objective is to prevent them from attacks by predators and/or pathogens. Traditionally since ancient times, different cultures have used these compounds for the prevention and treatment of various human diseases. During the last few years, it has been reported that most of these phytochemicals possess a variety of interesting and significant biological properties, such as analgesic, antiallodynic, antidiabetic, antioxidant, antiparasitic, antimicrobial, antiviral, antiatherogenic, anti-inflammatory, antiproliferative, antitumor and normal growth stimulants, as well as significant cardioprotective and neuroprotective activity. This thematic book aims to collect and disseminate some of the most significant and recent contributions of the use of the natural compounds called phytochemicals, as well as some of their chemical derivatives, for the prevention and treatment of cancer and other accompanying diseases. On the other hand, in recent years, the synthesis of numerous chemical derivatives of these natural compounds has also intensified, with the aim of enhancing their bioactive capacities. Among all these bioactivities, special attention has been paid to its antitumor capacity through the potential modulation of cancer initiation and growth, cell differentiation, apoptosis and autophagy, angiogenesis, and metastatic dissemination. In addition, a considerable number of studies have linked their anticancer effects to their anti-inflammatory and antioxidant activities.

total phenolic content --- total flavonoid content --- GC-MS --- DPPH --- antioxidant --- anticancer agent --- anti-inflammatory agent --- gingival fibroblasts --- oral cancer --- natural extract --- Adenosma bracteosum --- extract --- anti-cancer --- cell line --- isolated compounds --- caspase-3 --- bioactive compounds --- metabolites --- wine --- grapes --- breast cancer --- chemoprevention --- chemotherapy --- squamous cell carcinoma --- Moringa oleifera --- 3-hydroxy-β-ionone --- antioxidant activity --- antioxidant enzymes --- anti-proliferative activity --- maslinic acid --- melanoma --- Olea europaea L. --- ROS levels --- photodynamic therapy --- cancer --- photosensitiser --- natural compounds --- Elaeagnus angustifolia --- EMT --- apoptosis --- AKT/PI3K signaling pathway --- human hepatocarcinoma HepG2 cells --- migration activity --- proliferation --- oxidative stress --- ROS level --- uvaol --- lung metastases --- in vivo --- complementary medicine --- medicinal mushrooms --- triterpenoic acid --- tormentic acid --- betulinic acid --- oleanolic acid --- rhodamine B --- cytotoxicity --- hepatocellular carcinoma (HCC) --- Pogostemon cablin (PPa extract) --- cell cycle --- synergism --- natural photosensitive compounds --- anticancer activity --- hypericin --- emodin --- quinizarin --- danthron --- interaction --- DNA --- glioblastoma (GBM) --- lactucopicrin (LCTP) --- temozolomide (TMZ) --- autophagy --- NF-κB --- p62/SQSM1 --- natural product --- therapeutic triglyceride --- xenograft study --- Caveolin-1 --- actin cytoskeleton --- betulin glycoconjugates --- click chemistry --- 1,3-dipolar cycloaddition --- n/a