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The discovery of telomerase expression in a majority of tumors and the recognition of its potential role in the aging process has dramatically raised its profile as a target for therapeutic intervention. In Telomeres and Telomerase: Methods and Protocols, John A. Double and Michael J. Thompson have collected a critically important series of novel and essential techniques for studying telomeres and telomerase. These readily reproducible protocols provide cutting-edge tools to identify, measure, and analyze telomeres, to determine telomerase expression at the RNA level, to determine telomerase activity, and to detect potential modifiers of this activity. The techniques for assaying telomerase activity range from standard radiological TRAP assays to nonradioactive methods, from non-PCR-based methods to techniques using real-time PCR. Written by investigators who have used the methods extensively, each protocol includes step-by-step instructions, tips on avoiding pitfalls, and invaluable notes that make all the difference to successful experimental outcomes. Broad-ranging and highly practical, Telomeres and Telomerase: Methods and Protocols provides molecular and cell biologists, cancer researchers, and cellular pathologists with the core array of productive techniques needed today to develop telomerase inhibitors and clinically valuable diagnostic/prognostic telomerase markers.

Life sciences. --- Cell biology. --- Life Sciences. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Biosciences --- Sciences, Life --- Science --- Telomerase --- Telomere --- Chromosomes --- DNA polymerases --- Cytology. --- Monograph

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genetica --- genetische manipulatie --- genetische code --- dna --- genetische informatie --- Genetics --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Genetics.

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'The Art of Human Molecular Genetics 3 'CD-ROM contains the complete set of figures from the book for presentation. The figures are available in JPEG and PowerPoint format.

Human genetics --- genetica --- Molecular biology --- Molecular Biology --- Genome, Human --- Chromosome Mapping --- Genetic Screening --- Human molecular genetics --- Génétique moléculaire humaine --- Human molecular genetics. --- Genetics. --- 577.2 --- 57.083 --- 57.088 --- 575.1 --- 577.21 --- 612.015 --- DNA deoxyribonucleic acid --- DNA vingerafdruk --- Human Genome Project --- PCR polymerase chain reaction --- biologie --- celbiologie --- cellen --- chromosomen --- clonen --- erfelijke ziekten --- evolutie --- expressie --- genetische manipulatie --- gentherapie --- menselijke biologie --- microbiologie --- moleculaire biologie --- mutaties --- organen --- polymorfisme --- recombinant DNA --- weefsels --- Genetic Processes --- Genetic Structures --- Genetic Phenomena --- Molecular bases of life. Molecular biology --- Erfelijkheid. Overerving --- 577.2 Molecular bases of life. Molecular biology --- Genetic Testing. --- Génétique moléculaire humaine --- Genetics --- Molecular genetics --- Molecular Biology. --- Genome, Human. --- Chromosome Mapping. --- Moleculaire biologie --- Menselijke genetica --- GENOME, HUMAN --- HUMAN --- GENES --- CHROMOSOMES, HUMAN --- GENE EXPRESSION --- GENETIC TECHNIQUES --- HUMAN GENOME PROJECT --- GENETICS, POPULATION --- Humans. --- Genes. --- Chromosomes, Human. --- Gene Expression. --- Genetic Techniques. --- Human Genome Project. --- Genetics, Population. --- Acqui 2006 --- Humans --- Genes --- Chromosomes, Human --- Gene Expression --- Genetic Techniques --- Genetics, Population

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Het genetische onderzoek dat wetenschappelijke vorsers uitvoeren, is niet langer een zaak voor het laboratorium maar hoort thuis in het hart van onze maatschappij. Genetische technologie wordt gebruikt bij gerechtelijk onderzoek en als bewijs van historische vooronderstellingen. Bovendien wil de mens ook een keuze maken in de bepaling van zijn biologische oorsprong. Kinderen op maat gemaakt lijken plots niet meer veraf. Ingrepen in onze genetica hebben evenwel ook hun invloed op verzekerbaarheid, tewerkstelling en de privé-sfeer in het algemeen. De cruciale vraag dringt zich dan ook op of genetische testen leed voorkomen dan wel dat leed eerder veroorzaken. In hun boek Adam en Eva en andere verhalen over genetica schetsen David en Jean-Jacques Cassiman een duidelijk beeld van de Menselijke Erfelijkheid aan het begin van een nieuwe eeuw. Op een uiterst toegankelijke en intrigerende manier maken zij een balans op en plaatsen ze de feiten tegenover de emoties.

Human genetics --- Erfelijkheidsleer --- Hérédité --- Genetics, Medical. --- #GBIB:CBMER --- Academic collection --- 372.857.5 --- genetica (genen) --- gentherapie --- 600.2 --- DNA --- antropologie --- biologie --- erfelijkheidsleer --- exacte wetenschappen --- genetische manipulatie --- Ethiek (moraal, zedenleer) --- Genetica (erfelijke afwijkingen, erfelijke ziekten, erfelijkheid, erfelijkheidsleer, erfelijkheidsonderzoek, genetische aandoeningen) --- In-vitrofertilisatie --- Moraal (censuur) --- Erfelijkheid (genetica) --- Medische ethiek --- genetica --- Ethiek --- Genetische manipulatie --- genetisch risico --- Human Genetics --- Medical Genetics --- Genetics, Human --- Anthropology, Physical --- Chromosome Disorders --- Sex Chromosome Disorders --- Genetic Diseases, Inborn --- Molecular Medicine --- génétique (gènes) --- thérapie génique --- 61 --- Genetics, Medical --- DNA analysis --- Deoxypentose Nucleic Acid DNA --- Cloning --- Human genome project --- Genetics. --- Nature. --- Biology --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Genetic engineering --- Reproduction, Asexual --- Monograph

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42

Children with disabilities --- Down syndrome. --- Human chromosome abnormalities --- Intellectual disability. --- #PBIB:1999.4 --- Idiocy --- Intellectual disabilities --- Mental deficiency --- Mental retardation --- Developmental disabilities --- Psychology, Pathological --- People with mental disabilities --- Human chromosomes --- Chromosome abnormalities --- Genetic disorders --- 21 trisomy --- Down's syndrome --- Mongolism --- Mongolism (Disease) --- Trisomy 21 --- Intellectual disability --- Syndromes --- Human chromosome 21 --- Children with special educational needs --- Children with special health care needs --- Children with special needs --- Handicapped children --- Physically handicapped children --- Special needs children --- Exceptional children --- People with disabilities --- Abnormalities --- Downsyndroom --- Down syndrome --- Syndroom van Down