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This book reviews recent physicochemical and biophysical techniques applied in drug discovery research, and it outlines the latest advances in computational drug design. Divided into 10 chapters, the book discusses about the role of structural biology in drug discovery, and offers useful application cases of several biophysical and computational methods, including time-resolved fluorometry (TRF) with Förster resonance energy transfer (FRET), X-Ray crystallography, nuclear magnetic resonance spectroscopy, mass spectroscopy, generative machine learning for inverse molecular design, quantum mechanics/molecular mechanics (QM/MM,ONIOM) and quantum molecular dynamics (QMT) methods. Particular attention is given to computational search techniques applied to peptide vaccines using novel mathematical descriptors and structure and ligand-based virtual screening techniques in drug discovery research. Given its scope, the book is a valuable resource for students, researchers and professionals from pharmaceutical industry interested in drug design and discovery.

Physicochemistry --- Biological techniques --- General biophysics --- Clinical chemistry --- medische chemie --- biofysica --- biologische technieken --- fysicochemie

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Plant secondary metabolites are plant-based natural products that display a variety of pharmacological effects. This book discusses the invaluable bioactivity and multifaceted potential of these compounds. The book describes the physico-chemical and biochemical aspects of the plant secondary metabolites along with the chemistry, therapeutics and future perspectives of these plant secondary metabolites. Moreover, the book also discusses about various sources of plant secondary metabolites, and the metabolite determination through various analytical techniques. It further describes the potential applications of plant secondary metabolites as anticancer and chemo preventive agents, their role as cosmetic ingredients and activity in skin cancer therapy. Further chapters emphasize upon the plethora of roles of plant secondary metabolites, including those as antivirals, anti-bacterial, anti-inflammatory drugs, cardioprotective agents etc. The book culminates with chapters on the impact of certain plant secondary metabolites in plant defence and human healthcare. This book is meant for researchers and students in the field of pharmacology and plant sciences. Moreover, this book is also useful for industry experts especially working in the field of herbal therapeutics.

History of human medicine --- Physiology of nutrition. Metabolism --- Biotechnology --- systematische plantkunde --- farmacologie --- biotechnologie --- stofwisseling

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This book, the only one of its kind on ravine lands, reflects the significant advances made over the past two decades in our understanding of gully erosion, its controlling factors, and various aspects of gully erosion. It also addresses central research gaps and unanswered questions, which include historical studies on gully erosion to better understand the different stages of their formation; appropriate measuring techniques for monitoring or assessing the geological and hydrological parameters and processes involved in gully development; interaction of hydrological and other soil degradation processes; ecology and biodiversity of fragile ravines; impact of climate and environmental changes on soil erosion processes; development of effective and reliable gully erosion models; effective gully prevention and control measures; watershed-based management options; and ravine rehabilitation policies. The present book is a highly timely publication and deals with various aspects of ravine ecology and rehabilitation of degraded lands, particularly with the aid of biological approaches. As such, it offers a valuable guide for all scientists working in the fields of soil conservation / rehabilitation and agroforestry, students, environmentalists, educationists, and policymakers. More importantly, it focuses on the rehabilitation of one of the world’s most degraded and fragile ecosystems, ensuring the livelihoods of resource-poor farmers and landless families living in harsh ecologies that are more vulnerable to climate change.

Nature protection --- Meteorology. Climatology --- Animal ethology and ecology. Sociobiology --- Environmental protection. Environmental technology --- Pedology --- Agriculture. Animal husbandry. Hunting. Fishery --- Production management --- bodemkunde --- bodembescherming --- landbouw --- milieubeleid --- duurzame ontwikkeling --- natuurbescherming --- klimaatverandering --- milieubescherming

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This timely text/reference describes the development and implementation of large-scale distributed processing systems using open source tools and technologies such as Hadoop, Scalding and Spark. Comprehensive in scope, the book presents state-of-the-art material on building high performance distributed computing systems, providing practical guidance and best practices as well as describing theoretical software frameworks. Topics and features: Describes the fundamentals of building scalable software systems for large-scale data processing in the new paradigm of high performance distributed computing Presents an overview of the Hadoop ecosystem, followed by step-by-step instruction on its installation, programming and execution Reviews the basics of Spark, including resilient distributed datasets, and examines Hadoop streaming and working with Scalding Provides detailed case studies on approaches to clustering, data classification and regression analysis Explains the process of creating a working recommender system using Scalding and Spark Supplies a complete list of supplementary source code and datasets at an associated website Fulfilling the need for both introductory material for undergraduate students of computer science and detailed discussions for software engineering professionals, this book will aid a broad audience to understand the esoteric aspects of practical high performance computing through its use of solved problems, research case studies and working source code. K.G. Srinivasa is Professor and Head of the Department of Computer Science and Engineering at M.S. Ramaiah Institute of Technology (MSRIT), Bangalore, India. His other publications include the Springer title Soft Computing for Data Mining Applications. Anil Kumar Muppalla is also a researcher at MSRIT.

Programming --- Computer architecture. Operating systems --- Information systems --- Artificial intelligence. Robotics. Simulation. Graphics --- Computer. Automation --- beeldverwerking --- datamining --- computers --- programmeren (informatica) --- KI (kunstmatige intelligentie) --- computernetwerken --- data acquisition

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This edited book first gives an overview of issues in the studies of atmospheric sciences and then elaborates on extreme events in air pollution, their assessment, impacts, and mitigation strategies. It covers general overview of factors governing in atmosphere that lead to air pollution, description about recent and hazardous air pollution episodes, emergencies and extremes in atmospheric sciences, impact studies on living organisms and atmosphere related to emergencies and possible remedies/mitigation strategies which may also include green growth strategies for management. Increase in anthropogenic activities from different sources results in very high concentrations of air pollutants in the atmospheres and they lead to cause disturbance in seasonal cycles and atmospheric phenomena, ecological imbalance and change in the quality of air. These impacts are the major cause of short-term or long-term effects on living and non-living systems. In the recent years, several instances of extremes atmosphere and air pollution related emergencies causing accidental episodes, fog, smog, health related, heat and cold wave etc. are experienced. This book brings the attention on such issues in atmospheric sciences and discuss the disaster preparedness and management plus emergencies. This book is valuable reading material for students in Environmental Science, Biological Science, Medical Science, Policy Planning, Disaster Management and Agriculture. It's useful for environmental consultants, researchers and other professionals involved in air quality, plant, humans and disasters related research.

Nature protection --- Measuring methods in physics --- General ecology and biosociology --- Environmental protection. Environmental technology --- environment --- milieuchemie --- milieutechnologie --- milieubeheer --- bindingen (chemie)