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This textbook discusses the systemic consequences of cancer, covering a range of topics from tumor-promoting systemic effects to the development of cachexia, as summarized in the introductory chapter 1. Part I of this textbook focuses on tumor-promoting systemic effects and begins with a chapter on how tumor-derived extracellular vesicles and particles lay the foundation for future metastases (Chapter 2). Chapter 3 discusses how metastatic cells that have colonized the bone impact the local bone microenvironment, neighboring muscles, and host physiology. Chapter 4 summarizes the available strategies for targeting metastatic cancer and emphasizes the need to incorporate a systemic view of the disease. Following this overview of the systemic effects of cancer progression, Part II of the textbook discusses cancer-induced cachexia, a debilitating systemic effect of advanced cancer. Chapters 5-7 examine the key signaling pathways (interleukin-6/GP130, NF-kB, and muscle proteolysis) that drive the development of cancer cachexia. Chapters 8 and 9 in Part III of this textbook explore how toxicities from anti-cancer therapy are associated with the onset of cachexia in cancer patients, and provide insight into potential approaches to simultaneously target both cancer and cachexia. Chapters 10 and 11 (Part IV) conclude this textbook by outlining promising approaches for the diagnosis and treatment of cachexia as well as strategies to prevent the development of cachexia through exercise. An understanding of the systemic effects of cancer is essential for the design of effective anti-cancer and anti-cachexia treatment strategies. As such, this textbook provides key information for both students and scientists engaged in cancer research and oncology.

Histology. Cytology --- Immunology. Immunopathology --- Oncology. Neoplasms --- immunologie --- oncologie --- cytologie --- histologie --- Cachexia. --- Body composition. --- Caquèxia --- Càncer --- Complicacions (Medicina)

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Human anatomy --- Animal physiology. Animal biophysics --- Pathological physiology. Pathogenesis --- Physiological Processes --- Physiology --- Physiologie --- Periodicals. --- Périodiques --- Physiology. --- Health Sciences --- Physiological Phenomena. --- Pharmacology --- Pharmacologies --- Pharmaceutical Preparations --- Physiological Concepts --- Physiological Phenomenon --- Physiological Process --- Concept, Physiological --- Concepts, Physiological --- Phenomena, Physiological --- Phenomenas, Physiological --- Phenomenon, Physiological --- Physiological Concept --- Process, Physiological --- Processes, Physiological --- pharmacology --- Periodicals --- Physiological Phenomena --- Périodiques --- EBSCOASP-E EJMEDEC EPUB-ALPHA-A EPUB-PER-FT MDPHYSIO WILEY-E --- Animal physiology --- Animals --- Biology --- Anatomy --- MDPHYSIO --- Physiological processes --- physiology. --- Physiologie. --- Biological Sciences --- animal physiology --- body composition --- ecophysiology --- electrophysiology --- excretion --- exudation --- fungus physiology --- growth and development --- metabolism --- microbial physiology --- nutrient use efficiency --- nutrition physiology --- ocular physiology --- oxygen requirement --- peak oxygen uptake --- physiological regulation --- physiological response --- physiological state --- physiological transport --- plant physiology --- psychophysiology --- reproduction --- secretion --- somatic incompatibility --- taxis (physiology) --- tissue distribution --- tropisms --- water requirement --- biochemistry --- pathophysiology --- physiologists

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Sports --- Dietary Supplements --- Exercise --- Nutrition Physiology --- Athletes --- Sportifs --- Exercice --- physiology --- Nutrition --- Periodicals. --- Physiological aspects --- Alimentation --- Périodiques --- Aspect physiologique --- Nutritional Physiological Phenomena. --- Dietary Supplements. --- physiology. --- Nutrition. --- Physiological aspects. --- Athletic Training & Coaching. --- Exercise & Fitness. --- Nutrition Science. --- Dietary Supplementations --- Food Supplementations --- Nutraceuticals --- Nutriceuticals --- Food Supplements --- Neutraceuticals --- Dietary Supplement --- Food Supplement --- Neutraceutical --- Nutraceutical --- Nutriceutical --- Supplement, Dietary --- Supplement, Food --- Supplementations, Dietary --- Supplements, Dietary --- Supplements, Food --- Exercise physiology --- Nutrition Phenomena --- Nutrition Physiological Concepts --- Nutrition Physiological Phenomenon --- Nutrition Process --- Nutritional Phenomena --- Nutritional Physiological Phenomenon --- Nutritional Physiology --- Nutritional Physiology Concepts --- Nutritional Physiology Phenomenon --- Nutritional Process --- Nutritional Processes --- Nutrition Physiological Phenomena --- Nutrition Processes --- Nutritional Physiology Phenomena --- Concept, Nutrition Physiological --- Concept, Nutritional Physiology --- Concepts, Nutrition Physiological --- Concepts, Nutritional Physiology --- Nutrition Physiological Concept --- Nutritional Physiology Concept --- Phenomena, Nutrition --- Phenomena, Nutrition Physiological --- Phenomena, Nutritional --- Phenomena, Nutritional Physiological --- Phenomena, Nutritional Physiology --- Phenomenon, Nutrition Physiological --- Phenomenon, Nutritional Physiological --- Phenomenon, Nutritional Physiology --- Physiological Concept, Nutrition --- Physiological Concepts, Nutrition --- Physiological Phenomena, Nutrition --- Physiological Phenomena, Nutritional --- Physiological Phenomenon, Nutrition --- Physiological Phenomenon, Nutritional --- Physiology Concept, Nutritional --- Physiology Concepts, Nutritional --- Physiology Phenomena, Nutritional --- Physiology Phenomenon, Nutritional --- Physiology, Nutrition --- Physiology, Nutritional --- Process, Nutrition --- Process, Nutritional --- Processes, Nutrition --- Processes, Nutritional --- Physical activity --- Warm-up --- Workouts (Exercise) --- Sports persons --- Sportspeople --- Sportspersons --- Physiological effect --- sports nutrition --- Herbal Supplements --- Herbal Supplement --- Supplement, Herbal --- Supplements, Herbal --- Functional Food --- Clinical exercise physiology --- Food --- Nutritional Sciences --- Phototrophic Processes --- Autotrophic Processes --- Heterotrophic Processes --- Chemoautotrophic Growth --- Health --- Physical education and training --- Sports personnel --- nutrition. --- sports. --- dietary supplements. --- exercise. --- nutrition physiology. --- nutrition --- assimilation (physiology) --- digestion --- energy 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requirement --- biochemistry --- pathophysiology --- physiologists --- athletics --- ball games --- games (sports) --- sport --- leisure, recreation and tourism --- archery --- winter sports --- athletes --- athletic fields --- athletic performance --- games --- golf courses --- sports equipment --- sports medicine --- swimming pools --- adapted feeding --- animal nutrition --- energy deficiencies --- energy intake --- feeding methods --- food availability --- human nutrition --- nutrient excess --- nutrient intake --- nutrigenomics --- nutrition research --- nutrition science --- nutritional adequacy --- nutritional status --- optimal nutrition --- plant nutrition --- weight control --- nutritional ecology --- trophic levels --- trophic relationships --- Nutritionary hygiene. Diet --- Human medicine --- Agriculture. Animal husbandry. Hunting. Fishery --- Nutritional Physiological Phenomena