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This monograph brings forth biomechanical research methods and outcomes on human tissue experiments such as those of the brain and the heart under a single umbrella. Different mechanical characterization techniques employed in human tissue property estimation are presented in detail. The contents also focus on a hyperelastic constitutive model (e.g., Mooney-Rivlin, Ogden) for both isotropic and anisotropic tissue characterization. It also discusses energy dissipation in soft tissues and associated viscoelasticity. Human tissues, including skin, muscles, connective tissues, and tissues in all functional organs are listed and their mechanical properties are presented in detail. These tissue properties are indispensable for computational modeling of biological systems, validation of biomechanical tissue testing, medical simulation through development of artificial phantoms and surrogates, and testing of medical devices and interventions. This book will serve as a key reference for research in tissue engineering & biomedical engineering, medical simulation, biomechanics, finite element modeling of biological systems, biomaterials, biotechnology, implant and medical device development, and healthcare wearables. .
General biophysics --- Pharmacology. Therapy --- Human medicine --- biologische materialen --- geneeskunde --- histologie --- Biomaterials. --- Regenerative medicine. --- Biomedical Materials. --- Regenerative Medicine and Tissue Engineering.
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"Regenerative Medicine Research is an open access, online journal that publishes research relating to both the fundamental and practical aspects of regenerative medicine, with a particular emphasis on translational research."
Regenerative medicine --- Médecine régénératrice --- Periodicals --- Périodiques --- Tissue Engineering. --- Artificial Organs. --- Regenerative Medicine. --- Regenerative medicine. --- Medicine, Regenerative --- Medicines, Regenerative --- Regenerative Medicines --- Artificial Organ --- Organ, Artificial --- Organs, Artificial --- Engineering, Tissue --- biomaterials --- cellular biology --- tissue repair mechanisms --- genomics --- Medicine --- Regeneration (Biology) --- Cell- and Tissue-Based Therapy --- Organ Culture Techniques --- Tissue Expansion --- Regenerative Medicine --- Guided Tissue Regeneration --- Regenerative Endodontics --- Human medicine --- Physiology --- Microphysiological Systems
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This book illustrates the importance and significance of regenerative medicine in stroke recovery. It discusses stem-cell-based treatment strategies and offers mechanistic insights into their role in neurological recovery. It also examines the challenges and advances in using adult stem cells for enhanced therapeutic efficacy. Further, it presents the strategies as well as the strengths and weaknesses of various delivery methods to administer stem cells in ischemic stroke. It examines the role of non-coding RNA in our understanding the stroke pathogenesis, their regulatory role in ischemic stroke and potential as biomarkers and therapeutic targets. Lastly, it explores exosomes in the treatment of stroke, and the underlying mechanism of their action as therapeutic vectors for stroke. Given its scope, it is an excellent resource for neurologists, neuroscientists and researchers involved in regenerative therapy for stroke.
Histology. Cytology --- Neuropathology --- neurologie --- stamceltransplantatie --- Cerebrovascular disease --- Regenerative medicine. --- Treatment. --- Malalties cerebrovasculars --- Rehabilitació mèdica
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This comprehensive volume discusses in vitro laboratory development of insulin-producing cells. It encompasses multiple aspects of islet biology—from embryonic development and stem cell differentiation to clinical studies in islet transplantation, regulation of islet beta-cell regeneration, pancreatic progenitors, mathematical modelling of islet development, epigenetic regulation, and much more. The chapter authors represent leading laboratories from around the world who contribute their international perspectives and global expertise. Collectively, they provide the reader with a concise yet detailed knowledge of processes and current developments in islet regenerative biology. Pancreatic Islet Biology, part of the Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers and clinicians in stem cells or endocrinology, especially those focusing on diabetes. .
Histology. Cytology --- Biology --- Pharmacology. Therapy --- Pathology of the metabolism --- Pathological endocrinology --- Human medicine --- Manufacturing technologies --- farmacologie --- stamcellen --- biologie --- geneeskunde --- diabetes mellitus --- stamceltransplantatie --- histologie --- Stem cells. --- Regenerative medicine. --- Tissue engineering. --- Diabetes. --- Stem Cells. --- Regenerative Medicine/Tissue Engineering.
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The book focuses on the emerging anti-aging approaches for maintaining better health in old age. It provides a current understanding of the underlying principle, possible targets, implementation approaches, and efficacy of the various anti-aging strategies. The chapters include a wide range of topics incorporating the major advances in anti-aging strategies, including telomerase activation, stem cell therapy, autophagy induction, sirtuin activation, and dietary restrictions. Further, it discusses the epigenetic mechanisms underlying aging-related processes and epigenetic strategies to delay and reverse aging-related diseases. The book covers the strategy based on tissue engineering and regenerative medicine for understanding the complexity of aging and restoring the functionalities of organ systems. It further presents the applications of melatonin supplementation-based anti-aging therapeutic intervention. Finally, the book reviews the ethical dimension of anti-aging intervention strategies. This book is immensely useful to scientists and researchers from various disciplines in the life sciences. .
Genetics --- Biology --- Pharmacology. Therapy --- Pathological biochemistry --- Human medicine --- medische biochemie --- biologie --- biomedische wetenschappen --- geneeskunde --- genetica --- histologie --- Regenerative medicine. --- Medicine—Research. --- Biology—Research. --- Genetics. --- Epigenetics. --- Regenerative Medicine and Tissue Engineering. --- Biomedical Research.
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This volume of the Springer book series Advances in Experimental Medicine and Biology covers potency assays, one of the most complex yet fundamental evaluations that critically influence stem cell regenerative medicine. Developing potency assays for cell-based medicinal products comes with numerous challenges due to the highly specialised nature of the application and purpose. This book provides the reader with the knowledge necessary to understand issues governing the successful development of potency assays, highlighting an international outlook of how the various challenges raised are being managed. Stakeholders concerned with potency assay development range from patient and clinician to contract research organisations, small and medium enterprise, regulatory authorities and even politicians. The value of potency assays is poised to increase given the inevitable watershed as early-stage clinical trials addressing safety progress to trials testing efficacy. Contributors from clinical, academic, industrial and regulatory sectors establish a broad point of view for guidance and timely debate. Potency assays require extensive collaboration across disciplines and sectors, as well as compromise and the authors aim to constructively address the many key aspects involved. Potency assays provide a quantitative measure of the biological activity of advanced therapy medicinal products (ATMPs) and thus are required for their market authorization. As the pace of ATMP development accelerates, the need to develop specific, accurate, and robust potency assays for each product is also accelerating. The volume Potency Assays for Stem Cell Advanced Therapy Medicinal Products presents a broad outlook on the development, quality attributes, and implementation of potency assays for ATMPs. The first few chapters introduce a nuanced historical perspective on the science of potency assay development, describe specific quality attributes of an idealized potency assay, indicate pitfalls associated with developing such assays for ATMPs, and review guidance recommended by regulatory authorities on assay suitability for product approval. Subsequent chapters highlight efforts to develop potency assays for specific ATMPs, including skeletal stem cells, mesenchymal stromal cells, extracellular vesicles, CAR T-cells, and discuss emerging technologies/platforms for potency assay design. The volume concludes with a chapter reviewing potency assays used for the release of commercial ATMP products, which amalgamates information contained in previous chapters. Overall, the knowledge contributed from leading authorities in both academia and industry is an ideal resource for technicians, scientists, clinicians, process engineers, and regulators working with ATMPs. —Donald G. Phinney, PhD Professor, Department of Molecular Medicine, Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology .
Histology. Cytology --- Pharmacology. Therapy --- Medical microbiology, virology, parasitology --- Human medicine --- medische microbiologie --- geneeskunde --- stamceltransplantatie --- histologie --- Stem cells. --- Regenerative medicine. --- Medical microbiology. --- Stem Cell Biology. --- Regenerative Medicine and Tissue Engineering. --- Medical Microbiology. --- Biology --- Science
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Bone regeneration --- Tissue engineering --- Bone regeneration. --- Tissue engineering. --- Bones --- Bone --- Regeneration --- Bones. --- Connective Tissue. --- Regenerative Medicine. --- Biomedical engineering --- Regenerative medicine --- Tissue culture --- Bone remodeling --- Regeneration (Biology) --- Bone Regeneration. --- Tissue Engineering. --- Engineering, Tissue --- Organ Culture Techniques --- Tissue Expansion --- Regenerative Medicine --- Guided Tissue Regeneration --- Cell- and Tissue-Based Therapy --- Osteoconduction --- Bone Regenerations --- Regeneration, Bone --- Regenerations, Bone --- Bone Density Conservation Agents --- Microphysiological Systems
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Regenerative medicine --- Immunology --- Tissue engineering --- Immunology. --- Regenerative medicine. --- Tissue engineering. --- Immune System Phenomena. --- Regenerative Medicine. --- Tissue Engineering. --- Engineering, Tissue --- Organ Culture Techniques --- Tissue Expansion --- Regenerative Medicine --- Guided Tissue Regeneration --- Cell- and Tissue-Based Therapy --- Medicine, Regenerative --- Medicines, Regenerative --- Regenerative Medicines --- Regenerative Endodontics --- Immune System Concepts --- Immune System Phenomenon --- Immune System Process --- Immune System Processes --- Concept, Immune System --- Concepts, Immune System --- Immune System Concept --- Phenomena, Immune System --- Phenomenon, Immune System --- Process, Immune System --- Processes, Immune System --- Seroconversion --- Biomedical engineering --- Tissue culture --- Medicine --- Regeneration (Biology) --- Immunobiology --- Life sciences --- Serology --- Microphysiological Systems
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The book examines recent developments in regenerative medicine and the use of musculoskeletal ultrasound. Musculoskeletal regeneration has become a prominent research topic, no doubt due to the sociological and economic pressures imposed by the current ageing population. The ever expanding role of regenerative medicine and the identification as well as characterization of stem cells have introduced a major paradigm shift in the field of musculoskeletal and sports medicine as well as orthopaedic surgery. Whereas in the past, diseased tissue was replaced with allograft material, current trends in research revolve around regenerating damaged tissue. Specifically, regenerative medicine stands in contrast to the standard treatment modalities which impair the body's natural abilities to facilitate endogenous repair mechanisms such as anti-inflammatory drugs; or destructive modalities (e.g., radiotherapy, nerve ablation, injections of botulinum toxin) and surgical interventions that permanently alter the functioning of a joint, bone or spine. When compared to other allopathic options (including knee and hip arthroplasty with a 90-day mortality rate of 0.7%), regenerative medicine treatment modalities have a lower incidence of adverse events with a growing body of statistically significant medical literature illustrating both their safety and efficacy. Focusing on the major values of regenerative medicine, this book with its 21 chapters is expected to fill an important void in the current literature. It will take that extra step to guide you in your day to day clinical practice. Featuring contributions from a large international group of leaders in regenerative medicine and musculoskeletal ultrasonography, this book is an authoritative reference for rheumatologists, physiatrists, sonographers, radiologists, physiotherapists and orthopaedic specialists.
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This contributed volume is dedicated towards the progress achieved within the last years in all areas of Cell Culture Engineering and Technology. It comprises contributions of active researchers in the field of cell culture development for the production of recombinant proteins, cell line development, cell therapy and gene therapy, with consideration of media development, process scale-up, reactor design, monitoring and control and model-assisted strategies for process design. The knowledge and expertise of the authors cover disciplines like cell biology, engineering, biotechnology and biomedical sciences. This book is conceived for graduate students, postdoctoral fellows and researchers interested in the latest developments in Cell Engineering.
Biological techniques --- Histology. Cytology --- Human biochemistry --- Pharmacology. Therapy --- Pathological biochemistry --- Human medicine --- Biotechnology --- medische biochemie --- biologische technieken --- bio-engineering --- biomedische wetenschappen --- geneeskunde --- biotechnologie --- cytologie --- histologie --- Medicine --- Biology --- Cytology. --- Regenerative medicine. --- Biomedical engineering. --- Biomedical Research. --- Cell Biology. --- Biological Techniques. --- Regenerative Medicine and Tissue Engineering. --- Biomedical Engineering and Bioengineering. --- Research. --- Technique. --- Enginyeria de teixits
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