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NEW INSIGHTS TO NEUROIMMUNE BIOLOGY

Neuroimmunology. --- Neuroimmunomodulation --- Immunology --- Neurosciences

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Neuroimmunology --- Neurosciences --- Pharmacology --- Therapeutics --- Neuroimmunomodulation --- Immunology

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"Insights to Neuroimmune Biology, Second Edition discusses the systemic regulatory network, coordinating, organizing and interpreting the rapidly accumulating knowledge. The ultimate goal of this book is to help readers understand the function of higher organisms, including man, in their entire complexity. This publication provides assessments and interpretations of accumulated experimental evidence, enabling the scientific community to keep abreast of essential advancements of our knowledge in a quest for understanding of the biology of higher organisms."--

Neuroimmunology. --- Neuroimmunomodulation --- Immunology --- Neurosciences --- Nervous System Diseases --- Nervous System --- immunology

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This volume contains data on multiple immunomodulators, many of which are also the products of hypothalamic brain cell neurosecretion. Interleukins (IL-1a, IL-1ß, IL-2, IL-4, IL-6, TNFa), immunophylin and ubiquitin as well as proline rich peptides, comprised of 10-15 amino acids are being produced in N. Supraopticus and N. Paraventricularis and then secreted into neurohypophysis. Along the neurosecretion of the mentioned cytokines, there are other immunomodulators, the primary structure of which had been completely deciphered such as: Immunophyllins, intracellular receptors of immunosuppressors FK506, cyclosporine A., rapamicin. They are peptidyl-prolyl-cis-trans-isomerases. There are novel immunological hypothalamic factors such as ubiquitin, macrophage migration inhibitory factor (MIF), as well as Thymosin ß 4(1-39). This data allowed us to propose the concept of neuroendocrine immune system of the brain.

Neuroimmunology. --- Neuroimmunomodulation --- Immunology --- Neurosciences --- Neurosciences. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system

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Brain --- Cytokines --- Neuroimmunomodulation --- Brain Chemistry --- Interleukin-1 --- Signal Transduction --- physiology --- physiology --- physiology --- physiology --- physiology