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This book traces the history of adenosine receptor research from molecular biology to medicinal chemistry to behavior, including their implications in disease and potential strategies as therapeutic targets. It provides the reader with a comprehensive overview of the adenosine receptors that includes information on all subtypes - A1, A2A, A2B and A3. Aspects addressed include the most up to date information on their functional distribution in the nervous and peripheral systems, behavioral roles in inflammation, cancer, pain and neurological diseases such as Huntington’s disease, Epilepsy, Parkinson’s disease and Alzheimer’s disease.
Adenosine --- Receptors. --- Adenocard --- Adenoscan --- Purine nucleosides --- Ribonucleosides --- Neurochemistry. --- Biochemistry --- Neurosciences
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Animal biochemistry --- Adenosine --- Adenocard --- Adenoscan --- Purine nucleosides --- Ribonucleosides --- Receptors
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Ribavirin --- Ribonucleosides --- Virus Diseases --- therapeutic use --- drug therapy
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Ribavirin --- Virus diseases --- Antiviral Agents --- Ribavirin --- Ribonucleosides --- Virus Diseases --- Congresses --- Chemotherapy --- Congresses --- therapeutic use --- therapeutic use --- drug therapy
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Homeostasis of key metabolites and metabolic health affects all bodily systems. Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system – including developmental disorders, acute nervous system injury, and neurodegenerative disorders. Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic functions. Increasingly it is appreciated that restoring metabolic health could promote normal nervous system activity, and improve behavior and cognition. Adenosine: A Key Link Between Metabolism and Central Nervous System Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system. Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism. At the same time, adenosine influences neuronal activity directly via receptors, and is involved in biochemical processes related to gene expression. Thus, adenosine is uniquely placed as a reciprocal and rapid link between changes in metabolism and changes in neuronal activity, and, on a longer time scale, to changes in gene expression and long term changes in cell function. Leaders in the field feature basic research on adenosine at the cellular level in the central nervous system, and relate these findings to its recognized potential in diverse acute and chronic disorders. This comprehensive overview of adenosine also highlights emerging adenosine-based treatments and associated opportunities for central nervous system disorders.
Adenosine. --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Adenocard --- Adenoscan --- Composition --- Medicine. --- Neurosciences. --- Neurobiology. --- Biomedicine. --- Biology --- Chemistry --- Medical sciences --- Purine nucleosides --- Ribonucleosides
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Antiviral agents --- Ribonucleosides --- Congresses --- congresses --- Antiviral Agents --- Ribavirin --- Antiviral Drugs --- Antivirals --- Agents, Antiviral --- Drugs, Antiviral --- Interferon Inducers --- Virus Diseases --- Viruses --- Virus Inactivation --- Conferences - Meetings --- ICN-1229 --- Rebetol --- Ribamide --- Ribamidil --- Ribamidyl --- Ribasphere --- Vilona --- Viramide --- Virazide --- Virazole --- Ribovirin --- Tribavirin --- ICN 1229 --- ICN1229 --- Virus diseases --- Viral diseases --- Viral infections --- Virus infections --- Communicable diseases --- Medical virology --- Pathogenic viruses --- Ribofuranosyltriazolecarboxamide --- Amides --- Antimetabolites --- Nucleosides --- Triazoles --- Testing&delete& --- Chemotherapy&delete& --- Congresses. --- congresses. --- Antiviral --- Antiviral Agent --- Antiviral Drug --- Agent, Antiviral --- Drug, Antiviral --- Testing --- Chemotherapy
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Adenylic acid --- Adenosine --- Adenine nucleotides --- Neurotransmitters --- Physiological effect --- Testing --- Congresses --- -Adenosine --- -Adenylic acid --- -Neurotransmitters --- #Lilly --- Chemical nerve transmitters --- Nerve transmitter substances --- Neural transmitters --- Neurohumors --- Neuroregulators --- Synaptic transmitters --- Transmitters, Chemical nerve --- Transmitters, Synaptic --- Neurochemistry --- Neural transmission --- Adenine ribonucleotide --- Adenine-ribose phosphate --- Adenosine monophosphate --- Adenosine phosphate --- Adenosine phosphoric acid --- AMP (Biochemistry) --- Adenine --- Adenine nucleoside phosphates --- Adenosine phosphates --- Purine nucleotides --- Adenocard --- Adenoscan --- Purine nucleosides --- Ribonucleosides --- Adenylic acid - Physiological effect --- Adenosine - Physiological effect --- Adenosine - Testing --- Adenine nucleotides - Congresses --- Adenosine pharmacology --- Adenosine physiology
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Nutrient Metabolism, Second Edition, provides a comprehensive overview of the supply and use of nutrients in the human body and how the body regulates intake. Chapters detail the principles determining digestion and absorption of food ingredients and how these compounds and their metabolites get into the brain, cross the placenta and pass through the kidneys. Each nutrient's coverage contains a nutritional summary that describes its function, its food sources, dietary requirements, potential health risks if deficient, and impact of excessive intake. This handbook contains the latest informati
Metabolism. --- Metabolism and nutrition. --- Adenosine -- Metabolism. --- Molecular biology. --- Metabolic Phenomena --- Food --- Physiological Phenomena --- Growth Substances --- Physiological Effects of Drugs --- Food and Beverages --- Phenomena and Processes --- Technology, Industry, Agriculture --- Pharmacologic Actions --- Chemical Actions and Uses --- Chemicals and Drugs --- Micronutrients --- Metabolism --- Nutritional Physiological Phenomena --- Human Anatomy & Physiology --- Health & Biological Sciences --- Physiology --- Adenosine --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Adenocard --- Adenoscan --- Purine nucleosides --- Ribonucleosides --- Anabolism --- Catabolism --- Metabolism, Primary --- Primary metabolism
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RNA Modification provides a useful examination of the science and its role in biological regulation, the current frontier of life science research, and includes various RNA modications and their role in gene expression. It represents the most up-to-date knowledge and protocols available today.
RNA Processing, Post-Transcriptional --- Pseudouridine --- RNA, Transfer --- Gene Expression Regulation --- Uridine --- Biochemical Processes --- RNA --- Metabolism --- Genetic Processes --- Ribonucleosides --- Pyrimidine Nucleosides --- Biochemical Phenomena --- Chemical Processes --- Nucleic Acids --- Metabolic Phenomena --- Nucleosides --- Genetic Phenomena --- Nucleic Acids, Nucleotides, and Nucleosides --- Phenomena and Processes --- Chemical Phenomena --- Pyrimidines --- Chemicals and Drugs --- Heterocyclic Compounds, 1-Ring --- Heterocyclic Compounds --- Animal Biochemistry --- Human Anatomy & Physiology --- Health & Biological Sciences --- RNA editing. --- ARN --- pharmacokinetics --- Edition --- Editing, RNA --- Messenger RNA editing --- mRNA editing --- RNA Processing, Post-Transcriptional. --- pharmacokinetics. --- Genetic regulation
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This Book "A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics " documents the present state of knowledge of the adenosine A3 receptor. Adenosine A3 receptors are G protein-linked receptors that function in physiology and intracellular signaling and are involved in inflammatory responses and mediating cell proliferation and cell death. The A3 receptor is increasingly being recognized for its biological roles throughout the body, and many A3 receptor ligands have proven useful in elucidating peripheral and central pathologies. This book covers a wide range of information including data from studies of theoretical, molecular and cellular pharmacology, signal transduction, integrative physiology, new drug discoveries and clinical applications. The book includes sections on: A3 Adenosine Receptor signal transduction Adenosine Receptor medicinal chemistry Effects and therapeutic applications of Adenosine Receptors on tissues and organs Adenosine Receptors and inflammatory and auto-immune diseases Adenosine Receptors and cancer The chapters in this book cover both fundamental science and relevant applications and provide an authoritative account of the current status of the field. "A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics" is an up to date and scientifically excellent source of information, attractive to basic and clinical scientists alike.
Biomedicine. --- Pharmacology/Toxicology. --- Medicinal Chemistry. --- Cardiology. --- Pneumology/Respiratory System. --- Medicine. --- Toxicology. --- Biochemistry. --- Pneumology. --- Médecine --- Toxicologie --- Biochimie --- Cardiologie --- Adenosine -- Physiological effect. --- Adenosine -- Receptors. --- Neural transmission -- Regulation. --- Adenosine --- Neural transmission --- Natural Science Disciplines --- Receptors, Purinergic P1 --- Receptor, Adenosine A3 --- Chemistry --- Disciplines and Occupations --- Receptors, Purinergic --- Receptors, Cell Surface --- Receptors, Neurotransmitter --- Receptors, G-Protein-Coupled --- Membrane Proteins --- Proteins --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Health & Biological Sciences --- Human Anatomy & Physiology --- Neuroscience --- Pharmacy, Therapeutics, & Pharmacology --- Animal Biochemistry --- Receptors --- Physiological effect --- Regulation --- Receptors. --- Physiological effect. --- Regulation. --- Regulation of neural transmission --- Adenocard --- Adenoscan --- Pharmacology. --- Medicinal chemistry. --- Respiratory organs --- Diseases. --- Biological control systems --- Purine nucleosides --- Ribonucleosides --- Heart --- Internal medicine --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Diseases --- Composition --- Toxicology --- Respiratory organs—Diseases. --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Drug effects --- Medical pharmacology --- Chemotherapy --- Pharmacy
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