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With the increasing emergence of viral infections worldwide, researchers are working to develop new and non-conventional treatments for infectious diseases. This is particularly true for SARS-CoV-2, which initiated a pandemic in 2019. With a focus on coronavirus, this book provides an overview of antiviral agents and new approaches to drug design. It includes five chapters that address new avenues for drug discovery, reprofiling of current drugs, computer-aided drug design, and more.
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This book captures the state of the science with twenty reviews that examine the latest in today's antiviral drug discovery efforts. These reviews range from in-depth analyses of a specific viral target, to examination of multiple targets in medically important viruses. This book is certain to help stimulate new ideas and approaches for virologists, biochemists, pharmaceutical chemists, and other investigators.
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Antiviral agents --- Antiviral Agents. --- Drug Design. --- Design
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Regularly reviewing the ""state-of-the-art"" developments in the antiviral drug research field, this latest volume spans the conceptual design and chemical synthesis of new antiviral compounds. It discusses their structure-activity relationship, mechanism and targets of action, pharmacological behavior, antiviral activity spectrum, and therapeutic potential for clinical use.
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Each of the chapters in Disinfection of Viruses touches on virucidal efficacy for SARS-CoV-2, the causative agent for the COVID-19 disease, or enveloped viral surrogates. SARS-CoV-2 is an enveloped virus of the Coronaviridae family and therefore is expected to be susceptible to all classes of microbicides. The book is divided into three sections. Section 1: "Microbicides for Viral Inactivation," includes chapters on the efficacy of chemical virucides, Section 2: "Physical Inactivation Approaches," includes a chapter on the efficacy of gamma irradiation, ultraviolet light, and heat for inactivating coronaviruses, and Section 3: "Viral Persistence and Disinfection," includes data on viral persistence for SARS-CoV-2, as these data inform the need for and the approaches that might be used for disinfection.
Antiviral agents. --- Herbs --- Therapeutic use.
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The articles that appear in Antiviral Drugs - Aspects of Clinical Use and Recent Advances cover several topics that reflect the varied mechanisms of viral disease pathogenesis and treatment. Clinical management and new developments in the treatment of virus-related diseases are the two main sections of the book. The first part reviews the treatment of hepatitis C virus infection, the management of virus-related acute retinal necrosis, the use of leflunomide therapy in renal transplant patients, and mathematical modeling of HIV-1 treatment responses. Basic research topics are dealt with in the second half of the book. New developments in the treatment of the influenza virus, the use of animal models for HIV-1 drug development, the use of single chain camelid antibodies against negative strand RNA viruses, countering norovirus infection, and the use of plant extracts to treat herpes simplex virus infection are described. The content of the book is not intended to be comprehensive, but aims to provide the reader with insights into selected aspects of established and new viral therapies.
Antiviral agents. --- Virus diseases --- Chemotherapy. --- Antiviral agents --- Antiviral drugs --- Antivirals --- Anti-infective agents --- Virus inhibitors --- Chemotherapy --- Pharmacology
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Ribavirin has been studied for over 20 years as a potential therapy against a number of RNA and DNA viruses. It is well known that Ribavirin in combination with Interferon is a key antiviral component in the treatment of Hepatitis C virus infection. In this book, the authors discuss the biochemistry, clinical applications and potential side effects of Ribavirin. Topics include optimizing Ribavirin use for the treatment of Hepatitis C; Ribavirin and its great potential in infectious diseases; the antiviral actions of Ribavirin; a novel prediction method for the responsiveness of Hepatitis C pat
Ribavirin. --- Antiviral agents. --- Ribofuranosyltriazolecarboxamide --- Ribovirin --- Virazole --- Amides --- Antimetabolites --- Antiviral agents --- Nucleosides --- Triazoles --- Antiviral drugs --- Antivirals --- Anti-infective agents --- Virus diseases --- Virus inhibitors --- Chemotherapy
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Up-to-date review on the chemistry and biology of nucleosides Modern synthetic methodology Comprehensive coverage of antiviral nucleosides This book summarizes the recent advances in nucleosides chemistry and chemotherapy over the past 10-15 years. It covers recently discovered nucleoside antiviral agents, their therapeutic aspects and biochemistry, and also extensive reviews on their chiral synthesis.
Antiviral nucleosides --- Chiral drugs --- Synthesis. --- Enantiomeric drugs --- Enantiomerically pure drugs --- Drugs --- Enantiomers --- Antiviral agents --- Nucleosides
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Antiviral agents. --- Antiviral drugs --- Antivirals --- Anti-infective agents --- Virus diseases --- Virus inhibitors --- Chemotherapy
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