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More than 10,000 patients are hospitalized every year with Legionnaires' disease in the United States alone. Legionnaires' disease is also an important public health topic as it involves environmental and public issues, as far as its spread and prevention are concerned. With an aging population, increasing number of transplants, increasing use of immunosuppressive medications, and compromised immunity due to multiorgan system disease, Legionnaires' disease is emerging as an important disease.
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The newest Legionella volume is a comprehensive reference source, offering 131 chapters that are divided into four general subject areas covering clinical and diagnostic information, epidemiology, basic microbiology and pathogenesis, and environmental detection and control.
Legionella --- Legionellosis --- Legionnaires' Disease --- Legionnaires' disease --- Broad street disease --- Respiratory disease of Philadelphia --- Gram-negative bacterial infections --- Respiratory infections
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Legionella pneumophila was first isolated as the causative agent of a deadly infectious pneumonia at a convention of the American Legion forty years ago. Since then, Legionnaires’ disease continues to be a significant public health concern. Today, our understanding of the Legionella genus, comprising environmental bacteria and opportunistic human pathogens, has dramatically increased. The study of how pathogenic Legionella interact with host cells, both protozoan and mammalian, has not only taught us about host-pathogen interactions but has revealed novel and unexpected insights into human cell biology and immunology. The capacity of pathogenic Legionella to commandeer cellular processes such as eukaryotic vesicular trafficking to establish an ER-like replicative niche, reflects the exquisite ability of this pathogen to manipulate eukaryotic cell biology in order to replicate in an intracellular compartment. This requires the specific and targeted action of a cohort of translocated bacterial effector proteins. In addition, we have learnt much about cell autonomous innate immune sensing of intracellular bacteria through the inability of L. pneumophila to avoid intracellular mammalian defense mechanisms. Now, in the age of large-scale comparative “omics”, it is clear that different Legionella species utilize different cohorts of effectors to replicate inside eukaryotic cells. While we understand some of the strategies employed by L. pneumophila and L. longbeachae to replicate within eukaryotic cells, there is still much to learn about many aspects of the Legionella life cycle. This Research Topic highlights the latest findings regarding the biology of Legionella species, their interactions with eukaryotic host cells, and how the application of various technologies has increased our understanding of this important pathogen.
Host-Pathogen Interactions --- Legionnaires' Disease --- Legionella --- Dot/Icm effector --- intravacuolar pathogen
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Legionella. --- Legionnaires' disease --- Drinking water --- Water --- Prevention. --- Contamination --- Distribution --- Safety measures. --- Potable water --- Tap water --- Beverages --- Fresh water --- Hydrology --- Broad street disease --- Legionellosis --- Respiratory disease of Philadelphia --- Gram-negative bacterial infections --- Respiratory infections --- Legionellaceae
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Legionella pneumophila is an emerging human pathogen that resides in natural environments as a parasite of freshwater. There have been new developments in this field including the publication of three whole genome sequences, the discovery of a developmental cycle and novel cyst-like highly infectious form, and the bacteria have been used as a probe for macrophage cellular function to unravel fundamental new knowledge in the area of cellular biology. Legionella has also become a model system for the study of innate as well as adaptive immunity. Information on Legionella continues to increase in the U.S. and abroad. Columbia University has started the first Legionella Genome Project with a multi-million dollar grant from the NIH. In addition, The European Working Group for Legionella infections was formed in 1986. Members are scientists with an interest in improving knowledge and information on the clinical and environmental aspects of legionnaires' disease through developments in diagnosis, management and treatment of the disease. The volume brings together all of the latest research on this pathogen, the interest in which is rapidly growing.
Legionella pneumophila. --- Legionnaires' disease bacterium --- Life sciences. --- Immunology. --- Infectious diseases. --- Microbiology. --- Life Sciences. --- Infectious Diseases. --- Legionella --- Emerging infectious diseases. --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Immunobiology --- Life sciences --- Serology --- Microbial biology --- Biology --- Microorganisms
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Climate change poses a serious challenge to our health and wellbeing. The increasing frequency of extreme weather events such as floods, droughts, and heatwaves, and the direct impacts of changes in temperature have direct impacts on health. At the same time, broader environmental change affects infectious disease risk, air pollution, and other forms of exposure. The different ways in which climate change will affect health are complex, interactive, and different communities are disproportionately affected. International actions such as the Paris Agreement and the Sustainable Development Goals recognise the future risks to society and acknowledge that we are already committed to a certain level of climate change. Future adaptation measures therefore need careful assessment and implementation for us to be able to minimise the potential risks from climate change and, at the same time, maximise the potential health benefits of a cleaner, greener world. This Special Issue comprises original research articles and detailed reviews on the likely impacts of climate change on health in a range of geographical settings, and the potential for adaptation measures to reduce some of these risks. Ultimately, studies like these will motivate policy level action for mitigation and help in determining the most effective methods of adaptation to reduce negative impacts in future through embedding scientific evidence into practice.
heat-waves --- heat-related mortality --- 2003 --- 2015 --- climate change --- Germany --- air temperature --- hot days --- heat waves --- city --- urban area types --- Poznań --- Poland --- ambulance 999 calls --- extreme weather --- resource planning --- London --- UK --- heat --- mortality --- adaptation --- dwellings --- indoor temperature --- cold days --- cold waves --- health systems --- climate adaptation --- health infrastructure --- rescue services --- Northern Europe --- disaster risk reduction --- Sendai Framework --- demographic change --- infectious diseases --- vector-borne diseases --- aerosolized exposures --- pollen --- well-being --- public health --- land management --- patient and public involvement (PPI) --- land-use --- El Niño Southern Oscillation --- ENSO --- health --- climatic variability --- climate-sensitive disease --- workplace --- heat stress --- productivity loss --- beta distribution --- North Atlantic Oscillation --- weather --- emergency ambulance calls --- exacerbation of essential hypertension --- urban heat island --- urban planning --- heat resilience --- climate scenarios --- waterborne disease --- natural environment --- risks --- cryptosporidiosis --- cholera --- leptospirosis --- Legionnaires’ disease --- trends over time --- n/a --- Poznań --- El Niño Southern Oscillation --- Legionnaires' disease
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Legionella spp. are ubiquitous microorganisms that are widely distributed in aquatic environments. Water systems of large buildings, such as hospitals, hotels, and rental units are often contaminated by legionellae and various parameters such as physical, chemical, and microbial building water system characteristics can influence Legionella occurrence. A range of physical and chemical disinfection methods have been proposed to control Legionella contamination; however, to date, the most effective procedures have not been defined. There is a need to survey legionellae in water systems to prevent legionellosis. Although the assessment of L. pneumophila in water is typically performed by culture isolation on selective media, it has several limits. For this reason, alternative tools for rapid, sensitive, and specific detection of Legionella in water samples have been proposed. In order to increase knowledge on different aspects of Legionella contamination in the water environment, this book gathers research studies related to the occurrence of Legionella in water systems of different environments; the role of different factors that can influence the Legionella contamination, as well as the advantages and disadvantages of different methodological approaches.
WTP 828 --- Legionella --- risk assessment plan --- water quality --- microbial analysis --- chemical analysis --- distal site positivity --- hot water return line --- chlorine --- HPC --- temperature --- water management --- free-living amoebae --- biological biocide --- cooling towers --- Legionella pneumophila --- protozoa --- Vermamoeba --- Acanthamoeba --- potable water --- hospital water --- water disinfection --- legionellosis --- Dental unit waterlines --- Legionella spp. --- risk management --- disinfection --- SBT --- molecular diversity --- hotels --- Healthcare-Associated Infections (HAIs) --- Surgical Handwashing Outlets (SHWOs) --- sensor-activated faucets --- free-living amoebae (FLA) --- virulence genes --- Willaertia magna C2c Maky --- culture media --- environmental monitoring --- quality control --- first draw --- second draw --- biofilm --- whole genome sequencing --- premise plumbing systems --- Legiolert --- ISO 11731 --- plate culture --- potable water samples --- flint --- copper --- PEX --- iron --- premise plumbing --- Legionnaires’ disease --- culture --- BCYE and GVPC media --- MLVA-genotypes --- clonal complex --- West Bank --- non-tuberculous mycobacteria --- Pseudomonas --- Acinetobacter --- amoebae --- PVC --- drinking water --- ecotype --- groundwater --- environmental factors --- magnesium --- niche --- n/a --- Legionnaires' disease
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In the only history of its kind, Etheridge traces the development of the Centers for Disease Control from its inception as a malaria control unit during World War II through the mid-1980s . The eradication of smallpox, the struggle to identify an effective polio vaccine, the unraveling of the secrets of Legionnaires' disease, and the shock over the identification of the HIV virus are all chronicled here. Drawing on hundreds of interviews and source documents, Etheridge vividly recreates the vital decision-making incidents that shaped both the growth of this institution as well as the state of public health in this country for the last five decades. We follow the development of the institution as it was transformed by the will and the imagination of remarkable individuals such as Dr. Joseph Mountin, one of the first heads of the CDC. Often characterized as abrasive and impatient, Mountin pushed the CDC to become a vital player in eradicating the threat of communicable disease in the United States. Others such as Dr. Alexander Langmuir brought the expertise necessary to establish epidemiology as one of the primary functions of the CDC. Created to serve the states and to answer any call for help whether routine or extraordinary, the CDC is now widely recognized as one of the world's premier public health institutions.
Epidemiology --- Public Health --- Medicine --- Health Occupations --- Disciplines and Occupations --- Health & Biological Sciences --- Epidemiology & Epidemics --- Social Epidemiology --- Epidemiologies, Social --- Epidemiology, Social --- Social Epidemiologies --- Disease --- Health Professions --- Health Occupation --- Health Profession --- Profession, Health --- Professions, Health --- Occupations --- Medical Specialities --- Medical Specialties --- Medical Specialty --- Specialities, Medical --- Specialties, Medical --- Specialty, Medical --- Medical Speciality --- Speciality, Medical --- Health Workforce --- Community Health --- Environment, Preventive Medicine & Public Health --- Environment, Preventive Medicine and Public Health --- Health, Community --- Health, Public --- Preventive Medicine --- Education, Public Health Professional --- Diseases --- Public health --- History. --- history --- History --- epidemiology --- Centers for Disease Control (U.S.) --- United States. --- CDC (Centers for Disease Control (U.S.)) --- Centros de Control de Enfermedades --- Center for Disease Control --- Centers for Disease Control and Prevention (U.S.) --- United States --- american health. --- american politics. --- cdc. --- centers for disease control. --- communicable diseases. --- decision making. --- department of health and human services. --- disease control. --- disease prevention. --- environmental health. --- eradication. --- federal agency. --- first world war. --- food borne pathogens. --- health promotion. --- hiv virus. --- infectious diseases. --- legionnaires disease. --- malaria control unit. --- national public health institute. --- occupational safety. --- polio. --- public health. --- public safety. --- smallpox. --- united states of america. --- vaccine. --- world war.
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