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Proteases are enzymes that essentially ""eat"" protein. Without proteases, infectious organisms cannot properly mount an attack against a host. It is for this reason that proteases have become popular targets for drug discovery. Research has shown that if you can inhibit the protease, you can defend against the invading microbe. The defense against HIV, the virus that causes AIDS, is the best-documented case of the efficacy of protease inhibitors. Researchers are now trying to deploy this strategy against several infectious agents. This book gives information that is useful in that search.

Microbial enzymes. --- Protease inhibitors. --- Proteolytic enzymes.

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Virus inhibitors --- Virus diseases --- Antiviral agents --- Virus Inhibitors --- Virus Diseases --- Antiviral Agents --- immunology --- Antiviral Agents. --- Virus research --- Agents antiviraux --- Antiviraux --- Maladies à virus --- Virus --- Antiviral agents. --- Virus diseases. --- Virus inhibitors. --- immunology. --- Périodiques. --- Inhibiteurs --- Immunologie --- Antiviruses --- Viral diseases --- Viral infections --- Virus infections --- Antiviral drugs --- Antivirals --- Antiviral Drugs --- Agents, Antiviral --- Drugs, Antiviral --- Viruses --- Communicable diseases --- Medical virology --- Pathogenic viruses --- Anti-infective agents --- Interferon Inducers --- Virus Inactivation --- Chemotherapy --- Antiviral --- Antiviral Agent --- Antiviral Drug --- Agent, Antiviral --- Drug, Antiviral --- Virus Diseases. --- Viral Diseases --- Viral Infections --- Virus Infections --- Disease, Viral --- Disease, Virus --- Diseases, Viral --- Diseases, Virus --- Infection, Viral --- Infection, Virus --- Infections, Viral --- Infections, Virus --- Viral Disease --- Viral Infection --- Virus Disease --- Virus Infection --- Antiviraux. --- Periodicals. --- Viral Protease Inhibitors. --- Inhibitor of Viral Protease --- Virus Protease Inhibitors --- Inhibitors, Viral Protease --- Inhibitors, Virus Protease --- Protease Inhibitor, Viral --- Protease Inhibitors, Viral --- Protease Inhibitors, Virus --- Viral Protease Inhibitor --- Viral Proteases --- antagonists & inhibitors --- Viral Inactivation --- Inactivation, Viral --- Inactivation, Virus

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This book contains chapters written by experts in the field of the ubiquitin proteasome system and cancer. The authors have summarized current information on ubiquitin ligases and proteasomes as potential targets for cancer therapy. Topics covered in the book include an overview of ubiquitin ligases, deubiquitinating enzymes, and the proteasome. Specific diseases resulting from deregulated ubiquitin ligases, such as Von-Hippel-Lindau disease and Fanconi anemia are also discussed. Finally, novel approaches and drugs to target proteins involved in sumoylation, ubiquitination, and degradation are described.

Cancer -- Treatment. --- Protein drugs. --- Protein engineering. --- Recombinant proteins -- Therapeutic use. --- Amino Acids, Peptides, and Proteins --- Ubiquitins --- Diseases --- Enzyme Inhibitors --- Molecular Mechanisms of Pharmacological Action --- Chemicals and Drugs --- Pharmacologic Actions --- Chemical Actions and Uses --- Neoplasms --- Protease Inhibitors --- Ubiquitin --- Proteins --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- Animal Biochemistry --- Oncology --- Cancer --- Treatment. --- Protein pharmaceuticals --- Cancer therapy --- Cancer treatment --- Therapy --- Medicine. --- Cancer research. --- Human genetics. --- Immunology. --- Medical microbiology. --- Biochemistry. --- Biomedicine. --- Cancer Research. --- Medical Microbiology. --- Human Genetics. --- Biochemistry, general. --- Drugs --- Oncology. --- Microbiology. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Immunobiology --- Life sciences --- Serology --- Genetics --- Heredity, Human --- Human biology --- Physical anthropology --- Microbial biology --- Microorganisms --- Tumors --- Composition --- Cancer research

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Human milk is uniquely tailored to meet infants’ specific nutritional requirements. However, it is more than just “milk”. This dynamic and bioactive fluid allows mother–infant signalling over lactation, guiding the infant in the developmental and physiological processes. It exerts protection and life-long biological effects, playing a crucial role in promoting healthy growth and optimal cognitive development. The latest scientific advances have provided insight into different components of human milk and their dynamic changes over time. However, the complexity of human milk composition and the synergistic mechanisms responsible for its beneficial health effects have not yet been unravelled. Filling this knowledge gap will shed light on the biology of the developing infant and will contribute to the optimization of infant feeding, particularly that of the most vulnerable infants. Greater understanding of human milk will also help in elucidating the best strategies for its storage and handling. The increasing knowledge on human milk’s bioactive compounds together with the rapidly-advancing technological achievements will greatly enhance their use as prophylactic or therapeutic agents. The current Special Issue aims to welcome original works and literature reviews further exploring the complexity of human milk composition, the mechanisms underlying the beneficial effects associated with breastfeeding, and the factors and determinants involved in lactation, including its promotion and support.

high pressure processing --- n/a --- lipids --- supplementation --- protective factors --- infant --- carbohydrate --- mothers --- antioxidant capacity --- protein --- fat --- cytokines --- bioactive factors --- late preterm --- zinc --- infants --- docosahexaenoic acid (DHA) --- pregnancy --- eicosapentaenoic acid (EPA) --- Lipidomics --- magnesium --- omega-3 fatty acids --- vitamin D deficiency --- flow injection analysis --- human milk benefits --- multiple source method --- 3?-sialyllactose (3?SL) --- milk banking --- milk group --- pasteurization --- video instruction --- Milk Fat Globule Membrane --- bile salt stimulated lipase --- breastfeeding difficulties --- breastfeeding support --- prematurity --- carotenoids --- hormones --- phosphocholine --- amino acids --- targeted metabolomics --- high-performance liquid chromatography (HPLC) --- choline --- selenium --- ?-linolenic acid --- arachidonic acid (ARA) --- docosahexaenoic acid --- human milk fortification --- protease inhibitors --- celiac disease --- copper --- term --- adipokines --- iodine --- mammary gland --- nutritional status --- food frequency questionnaire --- neonate --- early breastfeeding cessation --- prospective study --- breastfeeding --- mothers’ own milk --- disialyllacto-N-tetraose (DSLNT) --- country --- lactating women --- undernourishment --- proteases --- preterm --- expressing --- dietary assessment --- retinol --- body composition --- duration of lactation --- passive immunization --- 2?-fucosyllactose (2?FL) --- phosphorus --- clinical trial --- growth factors --- infant formula --- digestive tract --- human milk oligosaccharides (HMO) --- sodium --- nutrition --- eicosapentaenoic acid --- lipid metabolites --- lactation --- nervonic acid --- ?-tocopherol --- macronutrients --- glycoprotein --- term infant --- term infants --- maternal diet --- promotion of breastfeeding --- potassium --- antioxidants --- maternal immunoglobulins --- Human Milk --- human milk --- Phospholipids --- flu vaccine --- lactational stage --- lactose --- storage --- dietary intake --- Preterm infant --- immune-active proteins --- colostrum --- human milk fat --- inadequate intake --- milk therapy --- endogenous peptide --- calcium --- fatty acids --- breast milk --- pumping --- secretor --- LC-MS --- n-9 fatty acid --- Lewis --- donor human milk --- antenatal --- online --- iron --- growth --- donor milk --- mothers' own milk