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Malaria is one of the leading killers in the world today. Though drugs against malaria have a long history, attempts to develop novel therapeutics spanned the twentieth century and continue today. In this historical study, Leo B. Slater shows the roots and branches of an enormous drug development project during World War II. Fighting around the globe, American soldiers were at high risk for contracting malaria, yet quinine-a natural cure-became harder to acquire. A U.S. government-funded antimalarial program, initiated by the National Research Council, brought together diverse laboratories and specialists to provide the best drugs to the nation's military. This wartime research would deliver chloroquinine-long the drug of choice for prevention and treatment of malaria-and a host of other chemotherapeutic insights. A massive undertaking, the antimalarial program was to biomedical research what the Manhattan Project was to the physical sciences. A volume in the Critical Issues in Health and Medicine series, edited by Rima D. Apple and Janet Golden.
History, 20th Century. --- Biomedical Research --- Malaria --- Chloroquine --- Antimalarials --- Quinoline --- Antimalarial agents --- Antiprotozoal agents --- Ague --- Chills and fever --- Intermittent fever --- Malarial fever --- Fever --- Protozoan diseases --- 20th Cent. History (Medicine) --- 20th Cent. History of Medicine --- 20th Cent. Medicine --- Historical Events, 20th Century --- History of Medicine, 20th Cent. --- History, Twentieth Century --- Medical History, 20th Cent. --- Medicine, 20th Cent. --- 20th Century History --- 20th Cent. Histories (Medicine) --- 20th Century Histories --- Cent. Histories, 20th (Medicine) --- Cent. History, 20th (Medicine) --- Century Histories, 20th --- Century Histories, Twentieth --- Century History, 20th --- Century History, Twentieth --- Histories, 20th Cent. (Medicine) --- Histories, 20th Century --- Histories, Twentieth Century --- History, 20th Cent. (Medicine) --- Twentieth Century Histories --- Twentieth Century History --- history. --- Therapeutic use --- History --- Research --- Treatment --- Chemotherapy
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This Special Issue of Cancers focuses on new advances in the treatment of renal cell carcinoma, both surgical and pharmacological (and combinations of these), and novel approaches to tackle treatment resistance and improve our understanding of this phenomenon.
renal cell carcinoma --- autophagy --- hydroxychloroquine --- chloroquine --- ROC-325 --- cysteine cathepsins --- cysteine cathepsin inhibitors --- lysosome --- renal cancer --- metastatic renal cell carcinoma --- immune-based combination therapies --- network meta-analysis --- PD-L1 --- predictive --- biomarker --- treatment --- TKIs --- mRCC --- biomarkers --- soluble factors --- immunotherapy --- renal cell carcinoma (RCC) --- sunitib resistance --- artesunate (ART) --- Traditional Chinese Medicine (TCM) --- growth inhibition --- ferroptosis --- reactive oxygen species (ROS) --- clear cell renal cell carcinoma --- ccRCC --- RCC --- kidney cancer --- evolution --- evolutionary trajectory --- metastatic --- second line therapy --- renal cell cancer --- immune checkpoint inhibitors --- tyrosine kinase inhibitors --- individualization --- genomic signature --- transcriptomic analysis
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Nutritional deficiencies, and different nutritional and dietary lifestyles, whether poor or absent of essential nutrients, aside from excess intake, can lead to inflammatory complications and loss of function. Bioactive compounds are non-nutritional components derived from plants, foods, and beverages with a multitude of biological effects. The improvement of analytical techniques has allowed scientific community to state that the regular consumption of bioactive phytochemicals is related to the prevention of numerous pathologies, through mechanisms that involve oxidative stress reduction, gene expression modulation, and even enzymatic activation inhibition.
quercetin --- nervous system --- molecular signals --- pharmacological potential --- cognitive impairment. --- micronuclei --- radioprotectors --- radiation effects --- melanoma --- PNT2 --- B16F10 cells --- Ulmus parvifolia --- wound healing --- matrix metalloproteinase --- transforming growth factor --- skin rejuvenation --- kaempferol --- naringin --- orientin --- rutin --- vitexin --- chlorogenic acid --- citric acid --- malic acid --- quinic acid --- rosmarinic acid --- curcumin --- nanocurcumin --- neurological disorders --- nanocarriers --- liposomes --- cancer --- diet --- flavonoids --- food supplements --- hormesis --- phytoestrogens --- sulforaphane --- resveratrol --- cardiovascular disease --- nanomedicine --- liposome --- nanoformulation --- RNA-dependent RNA polymerase --- remdesivir --- chloroquine --- SARS-CoV-2 --- COVID-19 --- spike glycoproteins --- Acorus calamus --- ethnomedicinal --- phytochemistry --- toxicity --- pharmacological action --- clinical trial --- neuroprotective --- neurological --- metabolic application --- kurarinone --- coronavirus --- HCoV-OC43 --- autophagy --- infection --- MRC-5 cell --- LC3 --- p62/SQSTM1 protein --- n/a
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The importance of natural products, and especially plant secondary metabolites, for the treatment of diseases and drug development has already been obvious in medicine for several thousand years. Thus, this Special Issue of MDPI Biomedicines collects eight top articles from the field as regular full papers in addition to five reviews. All of the published papers are a vibrant source of information on the therapeutic potential of plant secondary metabolites in the treatment of diseases and drug development.
Cannabis sativa (Cannabis) --- cannabinoids --- tetrahydrocannabinol (THC) --- cannabidiol (CBD) --- cannabinoid receptors (CB1 and CB2) --- Papaver somniferum (opium poppy) --- secondary metabolites --- ursolic acid --- NSCLC --- tumorsphere --- EGFR --- STAT3 --- MMP2 --- PD-L1 --- MAFLD --- tanshinone IIA --- phytochemical --- lipogenesis --- lipid accumulation --- LXRα --- malaria --- quinine --- chloroquine --- artemisinin --- onchocerciasis --- ivermectin --- moxidectin --- cancer --- vincristine --- vinblastine --- anabolic --- diabetes --- Duchenne muscular dystrophy --- β-ecdysone --- ecdysteroid --- ecdysterone --- Mas1 --- osteoporosis --- sarcopenia --- COVID-19 --- cardiometabolic diseases --- respiratory diseases --- natural product --- SARS-CoV-2 --- lung cancer --- United States Food and Drug Administration-approved drug --- natural remedy --- triterpenoid --- molecular ribbon --- Huisgen 1,3-dipolar cycloaddition --- amide bond --- multifunctional PEG3 derivative --- antimicrobial activity --- anti-HIV activity --- cytotoxicity --- supramolecular self-assembly --- phytocannabinoids --- cannabichromene --- thermos-TRPs --- TRPA1 --- α,α-dimethylheptyl effect --- betulinic acid --- BODIPY --- bevirimat --- cell-cycle --- fluorescent microscopy --- maturation inhibitor --- capsaicinoids --- endocannabinoidome --- microbiota --- overweight --- obesity --- food intake --- lipidomics --- metabolism --- alkaloids --- membrane fusion --- viral fusion inhibitor --- antiviral therapy --- curcumin --- cancer cells --- bioavailability --- curcumin derivatives --- curcumin analogues --- curcumin delivery systems --- natural product synthesis --- lignans --- inflammation --- NF-κB inhibition --- n/a
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Few neurotransmitter systems have fascinated as much as the opioid system (i.e., opioid ligands and their receptors). Over the years, scientific studies of the endogenous opioid system have uncovered a complex and subtle system that exhibits impressive diversity, based on its critical role in modulating a large number of sensory, motivational, emotional and cognitive functions. Additionally, its important therapeutic value for the treatment of many human disorders, including pain, affective and addictive disorders, and gastrointestinal motility disorders, has been of persistent interest. This book specifically covers a broad area of the opioid research, offering up-to-date and new perspectives about opioid drug discovery. The diversity among the discussed topics ranging from medicinal chemistry to opioid pharmacology, from basic science to translational research, is a testimony to the complexity of the opioid system that results from the expression, regulation and functional role of opioid ligands and their receptors. This book will serve as a useful reference to scientists while also stimulating continuous research in the chemistry and pharmacology of the opioid system, with the prospective for finding improved therapies of human diseases where the opioid system plays a central role.
thiazole --- piperazine --- tail-clip --- hot-plate --- acetic acid-induced writhing test --- opioid --- prodynorphin --- epigenetics --- transcription --- human brain --- morphine dosing --- behavior --- locomotor activity --- tolerance --- µ-opioid receptor --- DAMGO --- SR-17018 --- buprenorphine --- nalbuphine --- kappa opioid receptor agonist --- pruritis --- scratching --- mice --- TAT-HIV --- cholestasis --- chloroquine --- deoxycholic acid --- analgesic --- δ opioid receptor --- G-protein-biased agonist --- opioid peptide --- rubiscolins --- µ-opioid analgesics --- angiotensin receptors --- chronic pain --- neuropathic pain --- delta opioid receptor --- inverse agonist --- irreversible antagonist --- non-competitive antagonist --- molecular pharmacology --- free fatty acid receptors --- lipids --- opioid receptor --- colitis --- chemotype --- high-throughput screen --- allosteric modulation --- beta-arrestin --- molecular dynamics --- opioid receptors --- β-amino acids --- peptide synthesis --- receptor binding studies --- functional assay --- nociceptin/orphanin FQ receptor --- NOP receptor --- ligands --- nociceptin --- N/OFQ --- analgesia --- GPCR --- HS-731 --- peripheral opioid agonist --- binding --- selectivity --- molecular docking --- molecular dynamics simulations --- n/a --- fluorescence cross-correlation spectroscopy (FCCS) --- G protein-coupled receptor (GPCR) --- serotonin
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Lysosomal storage disorders are a heterogenoeus group of rare genetic conditions affecting worldwide population and often exhibiting severe clinical manifestations. During the last two decades, the joined collaboration between scientists and clinicians has allowed to offer valuable therapeutic options to affected patients. Therefore, the tight connection between basic science and clinical medicine represents the gold standard approach to these disorders. In this context, the present book collects a piece of current scientific advances in the knowledge of disease pathogenesis and in the development of novel diagnostic and therapeutic strategies for some of these diseases. Altogether, these articles define and recapitulate which essential steps are required during the clinical management of a rare inherited disorder and describe forthcoming advances and a breakthrough in the field of lysosomal diseases.
mucopolysaccharidosis IIIB --- quantitative proteomics --- NAGLU --- lysosomes --- Gaucher disease --- bone involvement --- enzyme replacement therapy --- substrate reduction therapy --- Osteoimmunology --- RANK/RANKL --- Osteopontin --- MIP-1β --- mucolipidosis II --- sortilin --- TGF-beta --- cathepsin D --- Fabry disease --- alpha-galactosidase A --- endocytosis --- lysosome --- IGF2R/M6P --- clathrin --- chloroquine --- lysosomal diseases --- precision medicine --- pharmacological chaperones --- gene therapy. --- Pompe disease --- lysosomal targeting --- autophagy --- gene therapy --- muscle --- satellite cells --- rhGAA --- glycogen --- lysosomal α-glucosidase --- GAA biomarker --- Gaucher Disease --- Wnt/β-catenin --- Dkk1 --- Wnt3a --- iPSC --- neuronopathy --- Krabbe disease --- Twitcher mouse --- psychosine --- visual system --- visual cortex --- astrogliosis --- mucopolysaccharidosis type I --- Hurler syndrome --- hematopoietic stem cell transplantations --- animal models --- experimental therapies --- axon guidance --- lysosomal storage disorders --- neuronal circuit --- α-galactosidase A --- A4GALT --- globotriaosylceramide (Gb3) --- globotriaosyl-sphingosine (lysoGb3) --- pharmacological chaperone therapy --- exosomes --- endocytic pathways --- neurodegenerative disease --- Parkinson disease --- lysosomal storage disorder --- viral vectors --- newborn screening --- variant interpretation --- second tier test --- tandem mass spectrometry --- lyso-Gb3 --- dried blood spot --- GLA gene --- globotriaosylsphingosine --- biomarkers
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Designing immunotherapeutics, drugs, and anti-inflammatory reagents has been at the forefront of autoimmune research, in particular multiple sclerosis, for over 20 years. Delivery methods that are used to modulate effective and long-lasting immune responses have been the major focus. This Special Issue focused on delivery methods to be used for vaccines, immunotherapeutic approaches, drug design, and anti-inflammatories and their outcomes in preclinical studies and clinical trials.
multiple sclerosis --- inflammation --- oxidative --- biomarker --- sample size --- autoimmune encephalitis --- plasma exchange --- autoimmunity --- immunotherapeutics --- clinical outcomes --- major depression --- bupropion --- S-adenosylmethionine --- vitamin D3 --- yoga --- craniopharyngioma --- fractionated stereotactic radiation treatments --- sphenoid sinusitis --- cranial nerve-VI palsy --- autoimmune diseases --- immune thrombocytopenic purpura --- alemtuzumab --- antibodies against GluR3 peptide --- cognitive impairment --- diagnosis --- neuropsychological assessment --- short intracortical inhibition --- intracortical facilitation --- fampridine --- walking disability --- TSPAN32 --- tetraspanins --- cellular immunity --- memory T cells --- tDCS --- neuroimaging --- positron emission tomography --- cerebral blood flow --- probiotics --- Streptococcus thermophilus --- ST285 --- MBP83–99 peptide --- mannan --- immune modulation --- agonist peptide --- gut microbiome --- gut–brain axis --- metagenomics --- disease-modifying treatments --- MS --- vaccine --- immunomodulation --- carriers --- B cell receptor --- delivery methods --- immunotherapy --- monoclonal antibodies --- T cell receptor --- tolerance --- diagnostic markers --- immunoglobulins --- kappa --- free light chains --- antigen-specific immunotherapies --- tolerogenic vaccines --- tolerance induction --- central nervous system --- myelin peptides --- myelin basic protei --- proteolipid protein --- myelin oligodendrocyte glycoprotein --- nanotechnology --- drug delivery nanosystems --- lipids --- polymers --- vaccines --- nanoparticles --- antigen-specific immunotherapy --- experimental autoimmune encephalomyelitis --- neurodegeneration --- chloroquine --- EAE --- dendritic cells --- microglia --- astrocytes --- oligodendrocytes --- conformational analysis --- peptides --- altered peptide ligands --- NMR spectroscopy --- NOE-constraints --- molecular dynamic --- trimolecular complex --- Multiple Sclerosis --- early-onset --- adult-onset --- Human Leucocyte Antigens --- immunogenetics --- clinical phenotype --- clinical outcome --- therapeutics --- antibody detection --- ELISA --- multivalency --- N-glucosylated peptide epitopes --- peptide --- conjugation --- MOG35-55 --- Graphite/SiO2 electrode --- voltammetry --- HPLC --- MS drugs
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This book collects 25 scientific articles from laboratories around the world, all of which use botulinum neurotoxins as the main protagonists of their studies. The use of botulinum neurotoxin in medicine, following its ability to inhibit the effects of various disorders of different etiology on the human organism, constitutes the main topic of each article presented here. This book, which is aimed at both students and medical professionals, attempts to summarize current knowledge about the use of botulinum toxin as a therapeutic agent in many diseases, ranging from spasticity to tremor, form motor dysfunction after stroke to neuropathic pain, from hyperactive muscle to migraine, and so on. Thanks to its simplified writing, accessible to an audience who may not be familiar with the mysteries of science, readers will get new insights into this biological toxin and its multiple applications, not simply relegated to its historical use to correct of face wrinkles. Both review and research articles are presented, not only concerning animal studies, but also clinical reports. This book will provide an up-to-date picture of the state-of-the-art of the possible development of novel applications of botulinum neurotoxins for future therapeutic purposes.
botulinum toxin --- limb tremors --- muscle selection --- biological effect --- various cell types --- neurotransmitter --- dermatology --- novel indication --- botulinum neurotoxin --- masticatory system --- maxillofacial bone --- dental occlusion --- orthognathic surgery --- sialorrhoea --- drooling --- salivary glands --- swallowing --- eccrine glands --- onabotulinumtoxin A --- incobotulinumtoxin A --- botulinum neurotoxins --- botulinum neurotoxin serotype A --- heavy chain --- botulinum neurotoxin serotype a heavy chain (BoNT/A HC) --- spinal cord injury (SCI) --- nerve regeneration --- growth associated protein 43 (GAP-43) --- superior cervical ganglion 10 (SCG10) --- neuronal processes --- neural regeneration --- Schwann cells --- glia --- spinal cord --- immunohistochemistry --- allodynia --- weight bearing --- sciatic static index --- walking track analysis --- itch --- SNARE --- VAMP --- mast cells --- compound 48/80 --- chloroquine --- spasticity --- botulinum toxin type A --- appropriate treatment --- Therapeutic Index --- pruritus --- antipruritic --- clinical --- experimental --- BoNT/A --- astroglia --- interleukins --- microglia --- TLR2 --- TLR4 --- Snap-23 --- pain --- cerebral palsy --- botulinum toxin A --- complex regional pain syndrome --- lumbar sympathetic ganglion block --- chronic pelvic pain --- overactive detrusor --- vaginism --- temporomandibular joint dislocation --- lateral pterygoid muscle --- botulinum toxin therapy --- synaptic transmission --- SNAP-25 --- epilepsy --- Parkinson’s disease --- neurotransmission blockade --- electrical activity --- prion disease --- new indications --- formulation --- delivery --- refractory chronic migraine --- tension headache --- medication overuse headache --- prophylactic treatment --- XEOMIN® --- BTX --- central neuropathic pain --- spinal cord injury --- post-stroke shoulder pain --- mouse test --- Clostridium tetani --- botulinum antitoxin --- food safety --- abobotulinumtoxinA --- upper limb spasticity --- post-stroke --- early use --- ONTIME --- clinical trial --- human --- urodynamics --- botulinum neurotoxin-A --- basal ganglia --- interspecies differences in motor behavior --- mouse --- rat --- interneurons --- hand tremor --- treatment --- electromyography --- kinematics --- essential tremor --- dystonic tremor --- tremor --- movement disorders --- Botulinum toxin --- upper limb biomechanics --- joint biomechanics --- diagnostic guidance --- clinical decision support --- spastic paresis --- electrical stimulation --- stroke management --- rehabilitation --- hand --- n/a --- Parkinson's disease
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