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Uniquely focusing on dynamic modeling, this volume incorporates metabolic regulation as a survival mechanism for cells, by driving metabolism through optimal investment of its resources for control of enzyme synthesis and activity. Consequently, the models have a proven record of describing various uptake patterns of mixed carbon substrates that have become significant in modern applications of biomass for the production of bioenergy. The models accurately describe dynamic behavior of microbes in nutrient environments with mixtures of complementary substrates, such as carbon and nitrogen. Modeling of large metabolic networks (including prospects for extension to genome scale) is enabled by lumped hybrid cybernetic models with an unparalleled capacity to predict dynamic behavior of knockout strains. This is an invaluable, must-have reference for bio-researchers and practicing engineers.

Bioenergetics.

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Fundamentos de Balanços deEnergia é um manual que aborda duma forma simples e pedagógica a realização debalanços energéticos em sistemas em estado estacionário. O manual cobre uma partesignificativa dos programas das disciplinas de Análise de Sistemas Químicos eBiológicos e Termodinâmica, dos atuais Mestrados Integrados em Engenharia Químicae Engenharia do Ambiente. O texto inicia-se com um conjuntofundamental de conceitos e definições que suportam a aplicação do princípio daconservação da energia, ou seja a realização de balanços energéticos. Emseguida apresenta-se a equação geral dum balanço de energia e aplica-se asistemas particulares, que não envolvem reação química. O cálculo das entalpias éabordado com detalhe em processos a temperatura variável (e pressão constante),nos processos de mudança de fase e de mistura. A última parte debruça-se sobrebalanços de entalpia em sistemas onde ocorre reação química, sendo dadoparticular relevo.

Bioenergetics.

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Bioenergetics --- History.

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Molecular biology. --- Bioenergetics. --- Biomolecules. --- Cell interaction. --- Cytology. --- Microbiology.

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Bioenergetics. --- Energy metabolism. --- Bioenergetics --- Metabolism --- Microbial respiration --- Energy balance (Biology) --- Energy budget (Biology) --- Energy dynamics (Ecology) --- Energy utilization (Biology) --- Biochemistry --- Energy budget (Geophysics)