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Hyperlipidemias --- Hypolipidemic Agents --- Dyslipidemias --- Antimetabolites --- Lipid Regulating Agents --- Therapeutic Uses --- Molecular Mechanisms of Pharmacological Action --- Lipid Metabolism Disorders --- Pharmacologic Actions --- Metabolic Diseases --- Chemical Actions and Uses --- Nutritional and Metabolic Diseases --- Chemicals and Drugs --- Diseases --- Anticholesteremic Agents --- Hypercholesterolemia
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Biomedical and Dental Materials --- Polysaccharides --- Biopolymers --- Biocompatible Materials --- Chitin --- Carbohydrates --- Manufactured Materials --- Specialty Uses of Chemicals --- Polymers --- Chemicals and Drugs --- Macromolecular Substances --- Technology, Industry, and Agriculture --- Chemical Actions and Uses --- Technology, Industry, Agriculture
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Noxae --- Age Groups --- Mental Disorders Diagnosed in Childhood --- Toxic Actions --- Persons --- Mental Disorders --- Chemical Actions and Uses --- Psychiatry and Psychology --- Chemicals and Drugs --- Named Groups --- Neurotoxins --- Developmental Disabilities --- Child --- Environmental Pollutants
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La recherche en endocrinologie a été un des points forts de la biologie française au cours des dernières décennies. Elle joue un rôle majeur sur le plan fondamental où, en dehors de son intérêt propre, elle sert de modèle à la compréhension des mécanismes généraux de signalisation. En outre, elle débouche sur certains des problèmes les plus préoccupants de santé publique, donnant lieu à de très importantes approches pharmacologiques et thérapeutiques. L'objet de ce rapport est d'évoquer les plus importants de ces problèmes, situés à l'interface des sciences médicales et des sciences de la société. du point de vue strictement médical, quatre questions se posent avec une acuité croissante : les relations entre hormones et cancers, le traitement substitutif de la ménopause, la contraception hormonale au long terme et l'influence de certaines hormones sur le développement de l'obésité et du diabète de type 2. Un autre sujet important concerne le vieillissement, conçu comme un ensemble complexe de facteurs biologiques, cognitifs, sociaux et finalement sociétaux. Un aspect, plus technique mais également de grande importance, concerne les perturbateurs hormonaux, des produits chimiques qui peuvent modifier de façon indésirable la production de certaines hormones. Un dernier aspect concerne l'utilisation des hormones hors de la médecine, notamment chez les animaux comestibles. L'ambition de ce rapport est de donner l'arrière-plan scientifique permettant de comprendre les mécanismes biologiques impliqués dans ce groupe de problèmes majeurs de santé publique. Les voies de recherches actuelles sont résumées, les voies futures sont indiquées et des recommandations sont présentées. Les principaux partenaires institutionnels intervenant dans chaque cas sont cités. Lorsqu'elles existent, les controverses scientifiques et quelquefois politico-médiatiques sont explicitées. L'ouvrage traite les questions suivantes: 1-Les cancers hormonodépendants: Les mécanismes de base, les cancers du sein, les cancers de la prostate. 2-Le traitement substitutif de la ménopause. 3-L'obésité, les diabète de type 2. 4-Les hormones et le vieillissement. 5-Les perturbateurs hormonaux 6-Les hormones en Zootechnie.
Hormones, Hormone Substitutes, and Hormone Antagonists --- Diseases --- Anatomy --- Pharmaceutical Preparations --- Physiological Effects of Drugs --- Pharmacologic Actions --- Chemical Actions and Uses --- Neoplasms --- Hormones --- Endocrine System --- academy of sciences --- hormones --- public health --- environment
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By Richard Evans Schultes, Harvard University, Cambridge, Massachusetts, and Albert Hofmann, Basel, Switzerland. With Forewords by I. Newton Kugelmass and Henrich Kluver. The Second Edition of this book encompasses all of the advances that have been made in this field since publication of the original text. Newly discovered hallucinogenic plants have been incorporated into the discussions along with new information on some well-known drugs. The authors continue to focus on the botany and chemistry of hallucinogens, although they also consider ethnobotanical, historical, pharmacological and psy
Hallucinogenic drugs. --- Hallucinogenic plants. --- Pharmaceutical chemistry. --- Hallucinogenic drugs --- Hallucinogenic plants --- Pharmaceutical chemistry --- Plants --- Physiological Effects of Drugs --- Central Nervous System Agents --- Psychotropic Drugs --- Therapeutic Uses --- Eukaryota --- Pharmacologic Actions --- Chemical Actions and Uses --- Plants, Medicinal --- Hallucinogens
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Pharmacotherapy is an important part of the treatment of major phychiatric disorders. Although psychiatric drugs can have benefits for patients, adverse syndromes are common, causing distress for patients. This book will help psychiatrists, GPs pharmacists and nurses manage adverse syndromes associated with psychiatric drugs.
Psychotropic drugs --- Psychotropic Drugs --- Central Nervous System Agents --- Therapeutic Uses --- Pharmacologic Actions --- Chemical Actions and Uses --- Chemicals and Drugs --- Pharmacy, Therapeutics, & Pharmacology --- Health & Biological Sciences --- Chemical Actions --- Actions, Chemical --- Actions, Pharmacologic --- Pharmacological and Toxicological Phenomena --- Drug Therapy --- Therapeutic Effects --- Therapeutic Effect --- Therapeutic Use --- Effect, Therapeutic --- Effects, Therapeutic --- Use, Therapeutic --- Uses, Therapeutic --- Central Nervous System Drugs --- Psychoactive Drugs --- Psychoactive Agent --- Psychoactive Agents --- Psychoactive Drug --- Psychopharmaceutical --- Psychopharmaceuticals --- Psychotropic Drug --- Agent, Psychoactive --- Agents, Psychoactive --- Drug, Psychoactive --- Drug, Psychotropic --- Drugs, Psychoactive --- Drugs, Psychotropic --- Psychopharmacology --- Side effects
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Central Nervous System Depressants --- Anesthesia and Analgesia --- Physiological Effects of Drugs --- Central Nervous System Agents --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Therapeutic Uses --- Pharmacologic Actions --- Chemical Actions and Uses --- Chemicals and Drugs --- Anesthesia --- Anesthetics --- Anesthetic Agents --- Anesthetic Drugs --- Anesthetic Effect --- Anesthetic Effects --- Anesthetic --- Agents, Anesthetic --- Drugs, Anesthetic --- Effect, Anesthetic --- Effects, Anesthetic --- Analgesics --- Chemical Actions --- Actions, Chemical --- Actions, Pharmacologic --- Pharmacological and Toxicological Phenomena --- Drug Therapy --- Therapeutic Effects --- Therapeutic Effect --- Therapeutic Use --- Effect, Therapeutic --- Effects, Therapeutic --- Use, Therapeutic --- Uses, Therapeutic --- Central Nervous System Drugs --- Drug Effects on Physiology --- Drug Physiological Effects --- Effects, Drug Physiological --- Physiological Effects, Drug --- Analgesia and Anesthesia --- CNS Depressants --- Depressants, CNS
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Basic Medical Endocrinology, Third Edition provides up-to-date coverage of rapidly unfolding advances in the understanding of hormones involved in regulating most aspects of bodily functions. The discussion focuses on molecular and cellular aspects of hormone production and action firmly rooted in the context of integrative physiology. Topics are approached from the perspective of a physiologist with four decades of teaching experience. This book is richly illustrated with both descriptive schematic diagrams and laboratory findings obtained in clinical studies. Each of the thir
Endocrine glands. --- Endocrinology. --- Endocrinology. Endocrine glands--Physiology. Endocrine Glands--physiology. Hormones--physiology. --- Hormones. --- Physiology. --- Endocrine System --- Hormones, Hormone Substitutes, and Hormone Antagonists --- Anatomy --- Chemicals and Drugs --- Physiological Effects of Drugs --- Pharmacologic Actions --- Chemical Actions and Uses --- Endocrine Glands --- Hormones --- Endocrine glands --- Ductless glands --- Gland of internal secretion --- Glands, Ductless --- Glands --- Chromaffin cells --- Internal medicine
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There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development.
Antineoplastic Agents -- pharmacokinetics. --- Antineoplastic Agents -- pharmacology. --- Antineoplastic agents -- Research -- Handbooks, manuals, etc. --- Antineoplastic agents. --- Antineoplastic agents --- Therapeutic Uses --- Pharmacologic Actions --- Chemical Actions and Uses --- Chemicals and Drugs --- Antineoplastic Agents --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Research --- Anticancer agents --- Antineoplastic drugs --- Antineoplastics --- Antitumor agents --- Antitumor drugs --- Cytotoxic drugs --- Inhibitors, Neoplasm --- Neoplasm inhibitors --- Pharmacy. --- Chemistry --- Medicine --- Drugs --- Materia medica --- Pharmacology --- Cancer --- Chemotherapy
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Bioactive materials play an increasingly important role in the biomaterials industry, and are used for a range of applications, including artificial organs, drug delivery systems, nanomedicine, and biosensors. Bioactive materials in medicine reviews the current status and ongoing development of bioactive materials for medical applications.Following an introduction to bioactive materials in medicine, part one covers the process of designing bioactive materials, including chapters on molecular design, nanotechnology, and tissue engineering. Part two focuses on the different applications
Bioactive compounds. --- Biocompatible materials. --- Biomedical materials. --- Biomedical and Dental Materials --- Chemicals and Drugs --- Specialty Uses of Chemicals --- Manufactured Materials --- Technology, Industry, and Agriculture --- Chemical Actions and Uses --- Technology, Industry, Agriculture --- Biocompatible Materials --- Health & Biological Sciences --- Biomedical Engineering --- Medicine. --- Health Workforce --- Biologically active compounds --- Compounds, Bioactive --- Compounds, Biologically active --- Compounds, Physiologically active --- Physiologically active compounds --- Chemicals
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