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This book captures in a single volume the wealth of information on the plasmid structure, function, and biology of all organisms that have been examined to date. Plasmids exhibit wide variations in size, modes of replication and transmission, host ranges, and the genes they carry and have provided us with a great understanding of basic life principles at the molecular level. Written by experts in the field, this book is a valuable source of up-to-date information, delivering the latest impacts on studies in the areas of plasmid types, genomes, purification analysis, and expression of recombinant proteins in bacteria. Plasmid utilization in the synthesis of plasmid-based vaccines, plasmids as genetic tools, and their applications in ecology and the evolutionary process are also covered. This book is a single source of valuable information for instructors and students in advanced undergraduate and graduate courses on plasmids. It will also appeal to researchers seeking to find new relationships between biological processes that are linked by plasmids to the environment.

Plasmids. --- Paragenes --- Cytoplasmic inheritance --- Genetic vectors --- Mobile genetic elements --- Extrachromosomal DNA --- Life Sciences --- Molecular Genetics --- Microbiology --- Genetics and Molecular Biology --- Biochemistry

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Megaplasmids are extrachromosomal genetic elements in the size range of 100 kb and larger. They are found in physiologically and phylogenetically diverse groups of bacteria and archaea. By definition, megaplasmids are not essential for the viability of their hosts under all growth conditions, but paradoxically many megaplasmids carry the genetic information for the defining and characteristic traits of the organism in which they reside. Microbial Megaplasmids reviews our knowledge of the extensively studied representatives, such as the catabolic plasmids of the pseudomonads, the rhizobial Sym plasmids, the Ti plasmids of the genus Agrobacterium and the giant enterobacterial virulence plasmids. It also presents snapshots of more recently discovered megaplasmids. The contribution of megaplasmids to the biology of their hosts is described, highlighting the interactions between megaplasmid and chromosomal genes.

Agriculture. --- Bacterial chromosomes. --- Bacteriology. --- Chromosomes, Bacterial. --- DNA Transposable Elements --genetics. --- DNA, Bacterial. --- Genome, Bacterial. --- Microbial genetics. --- Microbiology. --- Plant diseases. --- Plasmids --genetics. --- Plasmids. --- Microorganisms --- Paragenes --- Genetics --- Life sciences. --- Medical microbiology. --- Microbial genomics. --- Plant pathology. --- Life Sciences. --- Plant Pathology. --- Medical Microbiology. --- Microbial Genetics and Genomics. --- Applied Microbiology. --- Microbiology --- Botany --- Communicable diseases in plants --- Crop diseases --- Crops --- Diseases of plants --- Microbial diseases in plants --- Pathological botany --- Pathology, Vegetable --- Phytopathology --- Plant pathology --- Plants --- Vegetable pathology --- Agricultural pests --- Crop losses --- Diseased plants --- Phytopathogenic microorganisms --- Plant pathologists --- Plant quarantine --- Microbial biology --- Biology --- Genomics --- Microbial genetics --- Farming --- Husbandry --- Industrial arts --- Life sciences --- Food supply --- Land use, Rural --- Biosciences --- Sciences, Life --- Science --- Pathology --- Diseases and pests --- Diseases --- Wounds and injuries --- Cytoplasmic inheritance --- Genetic vectors --- Mobile genetic elements --- Extrachromosomal DNA