Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Cytology --- Biophysics --- Biochemistry --- Cell Biology. --- Biochemistry. --- Biophysics. --- Cytology. --- Cell biology --- Cellular biology --- Biological physics --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Composition --- Cells --- Cell --- Cell Biology --- Biology --- Cytologists --- Medical sciences --- Physics --- Chemistry --- Citología --- Biofísica --- Cells. --- Biology - General --- cells. --- cell biology --- acinar cells --- adipocytes --- aleurone cells --- antigen-presenting cells --- bacteriocytes --- blood cells --- bone marrow cells --- bundle sheath cells --- chondrocytes --- chromaffin cells --- chromatophores --- coelomocytes --- cultured cells --- endothelial cells --- epithelial cells --- eukaryotic cells --- fibroblasts --- germ cells --- giant cells --- gonadotropic cells --- granulosa cells --- guard cells --- hemocytes --- hepatocytes --- islets of Langerhans --- keratinocytes --- kidney cells --- Leydig cells --- luteal cells --- mast cells --- myocytes --- neoplasm cells --- neurosecretory cells --- nurse cells --- osteoblasts --- osteoclasts --- phagocytes --- plant root cells --- prokaryotic cells --- Schwann cells --- Sertoli cells --- somatic cells --- splenocytes --- spores --- stem cells --- stromal cells --- tenocytes --- teratocytes --- thecal cells --- vegetative cells --- artificial cells --- cell transplantation --- cell viability --- cellular microenvironment

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Women and men have probably never been concerned as much by their health as during this COVID-19 pandemic. In this context, lifestyle habits continue to be promoted as allies for daily prevention against diseases. This is valid also for metabolic diseases, among which many affect the liver and are risk factors for aggravating the disease course of COVID-19. In fact, liver diseases are currently a major global health problem. There is a huge range of liver diseases and non-alcoholic fatty liver disease (NAFLD) is the most common chronic hepatic condition, which in some patients progresses to cirrhosis and liver cancer. Currently, substantial efforts are being made to better understand NAFLD, especially, because there is no U.S. Food and Drug Administration (FDA)-approved pharmacological therapy. To explore this disease, metabolomics is the most recently developed omics technology after genomics, transcriptomics, and proteomics. Metabolomics is the large-scale analysis of molecules, known as metabolites that are intermediate or end products of metabolism found within cells, tissues, and biofluids. This technology has a very high potential to identify biomarker candidates for the future development of new therapeutics. The book features articles that address metabolomics technology and its use to document different liver functions and dysfunctions, with a major focus on NAFLD.

nonalcoholic fatty liver disease --- nonalcoholic steatohepatitis --- Fibrosis --- Liver biopsy --- Genomics --- Metabolomics --- Proteomics --- Transcriptomics --- nicotinamide --- NAFLD --- steatosis --- heat stress --- primary mouse hepatocytes --- metabolic profile --- GC-MS --- multivariate statistical analysis --- arachidonic acid --- docosahexaenoic acid --- inflammation --- fibrosis --- lipidomics --- mass spectrometry --- in vitro --- HepaRG --- sodium saccharin --- reference toxicants --- de novo lipogenesis --- carbohydrate response element-binding protein --- ChREBP --- diabetes --- glucose production --- glycogen --- glycolysis --- glycogen storage disease type I --- hexosamine --- pentose phosphate pathway --- acupuncture --- imflammation --- lipid metabolism --- oxidative stress --- metabolomics quantitative profiling --- 1H-NMR spectroscopy --- liver --- bile acids --- metabolomics --- rat plasma --- tandem mass spectrometry --- liquid chromatography --- acetaminophen --- hepatotoxicity --- biomarker --- premalignant --- alcoholic liver disease --- cholestasis --- cirrhosis --- NAFL --- NASH --- standard operating procedures --- urine --- blood --- feces --- tissue --- cells --- liver function --- nonalcoholic fatty liver --- liquid chromatography-mass spectrometry --- nuclear magnetic resonance spectroscopy --- metabolic pathway --- non-alcoholic fatty liver disease --- non-alcoholic steatohepatitis --- transcription factors --- metabolic stress --- lipid homeostasis --- glucose homeostasis

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book sets out clearly and effectively the preparation and working methods of laboratory techniques involving isolated hepatocytes and will make life easier for every laboratory worker concerned with these techniques.

Cell Separation --- Cells, Cultured --- Histocytological Preparation Techniques --- Liver --- 57.086 --- 57.086 Cytological and histological techniques --- Cytological and histological techniques --- Cytohistologic Preparation Technics --- Cytohistologic Preparation Technique --- Cytohistologic Preparation Techniques --- Cytohistological Preparation Technic --- Cytohistological Preparation Technics --- Cytohistological Preparation Technique --- Histocytologic Preparation Technic --- Histocytologic Preparation Technics --- Histocytologic Preparation Technique --- Histocytologic Preparation Techniques --- Histocytological Preparation Technic --- Histocytological Preparation Technics --- Histocytological Preparation Technique --- Preparation Technic, Cytohistologic --- Preparation Technic, Cytohistological --- Preparation Technic, Histocytologic --- Preparation Technic, Histocytological --- Preparation Technics, Cytohistologic --- Preparation Technics, Cytohistological --- Preparation Technics, Histocytologic --- Preparation Technics, Histocytological --- Preparation Technique, Cytohistologic --- Preparation Technique, Cytohistological --- Preparation Technique, Histocytologic --- Preparation Technique, Histocytological --- Preparation Techniques, Cytohistologic --- Preparation Techniques, Cytohistological --- Preparation Techniques, Histocytologic --- Preparation Techniques, Histocytological --- Technic, Cytohistologic Preparation --- Technic, Cytohistological Preparation --- Technic, Histocytologic Preparation --- Technic, Histocytological Preparation --- Technics, Cytohistologic Preparation --- Technics, Cytohistological Preparation --- Technics, Histocytologic Preparation --- Technics, Histocytological Preparation --- Technique, Cytohistologic Preparation --- Technique, Cytohistological Preparation --- Technique, Histocytologic Preparation --- Technique, Histocytological Preparation --- Techniques, Cytohistologic Preparation --- Techniques, Cytohistological Preparation --- Techniques, Histocytologic Preparation --- Techniques, Histocytological Preparation --- Cytohistological Preparation Techniques --- Cytohistologic Preparation Technic --- Analytic Sample Preparation Methods --- Cultured Cells --- Cell, Cultured --- Cultured Cell --- Organ Culture Techniques --- Coculture Techniques --- Cell Culture Techniques --- Culture Techniques --- Human Umbilical Vein Endothelial Cells --- methods --- cytology --- Liver cells --- Abdomen --- Biliary tract --- Cells --- Hepatic cells --- Hepatocytes --- Analysis. --- Cytology. --- Clinical chemistry --- Indicators and test-papers. --- Radioimmunoassay. --- Immunoassay. --- RNA-protein interactions. --- Proteins --- Synthetic antigens. --- Antigenic determinants. --- Metastasis --- Neoplasm Metastasis --- Technique. --- Immunology. --- Research --- Methodology. --- Physiopathology. --- Genetics. --- Hormones --- Calcium --- Biological Transport, Active --- Culture Media --- Cytology

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book serves to highlight the pharmacokinetics/drug–drug interactions and mechanistic understanding in relation to the drug-metabolizing enzymes and drug transporters.This book presents a series of drug metabolism and transport mechanisms that govern the pharmacokinetic features of therapeutic drugs as well as natural herbal medicines. It also covers the pharmacokinetic interactions caused by inhibiting or inducing the metabolic or transport activities under disease states or the coadministration of potential inhibitors. It also deals with microenvironmental pharmacokinetic profiles as well as population pharmacokinetics, which gives new insights regarding the pharmacokinetic features with regard to drug metabolism and transporters.

tofacitinib --- dose-dependent pharmacokinetics --- hepatic and intestinal first-pass effect --- rats --- catalposide --- in vitro human metabolism --- UDP-glucuronosyltransferase --- sulfotransferase --- carboxylesterase --- celecoxib --- drug–drug interaction --- fluorescence --- HPLC --- metabolism --- repaglinide --- HSG4112 --- anti-obesity agent --- stereoselectivity --- pharmacokinetics --- compound K --- protopanaxadiol (PPD) --- biliary excretion --- intestinal metabolism --- Carthamus tinctorius extract --- notoginseng total saponins --- comparative pharmacokinetic study --- large volume direct injection --- compatibility mechanism --- mertansine --- human hepatocytes --- cytochrome P450 --- UDP-glucuronosyltransferases --- sodium-glucose cotransporter 2 (SGLT2) inhibitors --- DWP16001 --- kidney distribution --- inhibition mode --- diabetes --- transporter-enzyme interplay --- influx transporter --- efflux transporter --- physiologically based pharmacokinetic model --- cytochrome P450 enzymes --- tiropramide --- healthy Korean subjects --- modeling --- population pharmacokinetic --- quercetin --- breast cancer resistance protein --- inhibitor --- prazosin --- sulfasalazine --- kinetic analysis --- food–drug interactions --- Caco-2 --- EpiIntestinal --- first-pass --- P-gp --- BCRP --- drug transporter --- CYP3A4 --- oral availability --- automatization --- drug absorption --- drug dosing --- head-and-neck cancer --- real-time measurements --- taxanes --- tissue engineering --- UHPLC-MS/MS --- metformin --- verapamil --- drug interaction --- organic cation transporter 2 --- renal excretion --- acute renal failure --- gentamicin --- cisplatin --- hepatic CYP3A1(23) --- creatinine clearance --- renal clearance --- nonrenal clearance

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family that historically has been associated with mild febrile illness. However, the recent outbreaks in Brazil in 2015 and its rapid spread throughout South and Central America and the Caribbean, together with its association with severe neurological disorders—including fetal microcephaly and Guillain-Barré syndrome in adults—have changed the historic perspective of ZIKV. Currently, ZIKV is considered an important public health concern that has the potential to affect millions of people worldwide. The significance of ZIKV in human health and the lack of approved vaccines and/or antiviral drugs to combat ZIKV infection have triggered a global effort to develop effective countermeasures to prevent and/or treat ZIKV infection. In this Special Issue of Viruses, we have assembled a collection of 32 research and review articles that cover the more recent advances on ZIKV molecular biology, replication and transmission, virus–host interactions, pathogenesis, epidemiology, vaccine development, antivirals, and viral diagnosis.

microRNAs --- antivirals --- reverse genetics --- nucleic acid computation --- viral pathogenesis --- plaque reduction neutralization test --- clinical trials --- viral genetic variation --- viral fitness --- pregnancy --- type I IFN antagonist --- prM-E proteins --- eye --- replicon --- antiviral responses --- Bacterial artificial chromosome --- gene expression --- NS1 protein --- viral permissiveness --- ZIKV–host interactions --- reporter virus --- viral persistence --- blood-retinal barrier --- virus like particles --- emerging arbovirus --- Non-human primates --- heme-oxygenase 1 --- mosquito surveillance --- antiviral compounds --- ZIKV-associated neurologic disorders --- external quality assessment --- outbreak control --- therapeutics --- cryptic promoter silencing --- testis --- neurons --- mutagenesis --- RNA-seq --- microsphere immunoassay --- host-directed antivirals --- molecular diagnostics --- Bayesian analyses --- astrocytomas --- Full-length cDNA infectious clones --- viral pathogenicity --- neural progenitor cells --- full-length molecular clone --- antiviral --- multiplex nucleic acid detection --- Asian-lineage --- nucleic acid strand exchange --- IgA --- African-lineage --- vaccines --- Zika --- research models and tools --- immune response --- IgG avidity tests --- polymerase chain reaction --- Asian lineage --- sexual transmission --- TLR7/8 --- neuropathogenesis --- cross-reactions --- genetic variability --- mosquito --- ZIKV --- infectious cDNA --- prostate --- host genetic variation --- monoclonal antibodies --- optimised --- anti-viral immunity --- QCMD --- arbovirus --- FSS13025 --- MR766 --- NS5 --- EQA --- testicular cells --- virus attachment --- flavivirus --- mosquito-borne flavivirus --- dsRNA --- boolean logic-processing nucleic acid probes --- Ziks virus --- viral replication --- Aedes aegypti --- infection --- natural history --- infectious RNA --- zika virus --- chimeric viruses --- subgenomic replicon --- replication --- human brain glial cells --- microglia cells --- hepatocytes --- bacterial artificial chromosome --- detoxification and immune system responses --- testes --- dengue viruses --- Zika virus --- insecticide resistance --- NS2A protein --- plasmid toxicity --- cell surface receptors --- serology --- viral evolution --- laboratory preparedness --- flaviviruses --- Tet-inducible --- dengue virus --- diagnosis --- assay standardization --- infectious clone --- ELISA --- innate response --- congenital Zika syndrome --- secondary infections --- apoptosis --- viral survival --- ocular --- validated --- rhesus macaques --- neuroinflammation --- placenta cells --- NHP --- Zika virus (ZIKV) --- point-of-care diagnostics --- isothermal nucleic acid amplification --- microcephaly --- cytopathic effects --- indirect immunofluorescence --- fetal infection --- therapy --- siRNA --- viral counteraction --- neural cells --- silvestrol --- eIF4A