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Après des décennies d’études descriptives, la biologie du cancer vit une véritable révolution : les approches génétiques ont permis d’identifier les dérégulations cellulaires en jeu dans les tumeurs et de développer des traitements ciblés. Des travaux précurseurs ont ainsi élucidé l’action combinée de l’arsenic et de l’acide rétinoïque sur la protéine responsable de la leucémie promyélocytaire. Ce traitement, qui a permis de guérir la quasi-totalité des patients, suscite l’espoir que la compréhension intime des mécanismes de la cancérogénèse puisse bientôt déboucher sur de nouvelles approches thérapeutiques transposables à d’autres cancers.

Multidisciplinary --- oncologie --- biologie cellulaire --- biologie moléculaire --- cancer --- cancerogénèse --- thérapeutique --- génétique --- oncogénèse --- leucémie --- biologie

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hematologie --- leukemie --- Pathological haematology --- Leukemie ; kinderen --- Kanker ; kinderen --- Leukemie --- Kwaadaardige gezwellen --- Oncologie --- Psychologie --- Kanker --- Jongeren --- 604.6 --- ziektebeleving --- Leucémie --- Cancer --- Jeunes --- 616.41 --- Biografieën --- Kwaadaardig gezwel --- Man --- Volwassene --- 960 --- kanker --- levensbeschrijvingen --- biographies et mémoires

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Leukemia covers all aspects of the research and treatment of Leukemia and Allied Diseases. Studies of normal hemopoiesis are covered because of their comparative relevance. Topics of interest include oncogenes, growth factors, stem cells, leukemia genomics, cell cycle, signal transduction, molecular targets for therapy and more.

Pathological haematology --- Leukemia --- Leucémie --- periodicals --- Periodicals --- Périodiques --- Leukemia. --- Leucocythaemia --- Leucocythemia --- Leucocythaemias --- Leucocythemias --- Leukemias --- Myeloproliferative Disorders --- Hematologic Neoplasms --- Health Sciences --- Life Sciences --- Clinical Medicine --- Hematology --- Medical Education, Training & Research --- Oncology --- Cytology, Cell Biology --- Leukemia & Lymphoma. --- Leucaemia --- Leucemia --- Leucosis --- Leukaemia --- Leukosis --- Anemia --- Cancer --- Leucocytosis --- Preleukemia --- Pathologische hematologie --- Cancer research --- Medicine --- Critical care medicine --- Internal medicine --- Medicine/Public Health, general --- Internal Medicine --- Intensive / Critical Care Medicine --- Cancer Research --- Tumors --- Haematology --- Blood --- Medicine, Internal --- Intensive care --- Intensive medicine --- Emergency medicine --- Intensive care units --- Health Workforce --- Diseases --- leukemie --- Journal --- Leukemia - Periodicals.