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The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting loss of key information. Each of the nineteen chapters is illustrated with figures and tables which clarify some of the more technical points being made. Also included is a drug discovery case history which draws the relevant material together into a single chapter. In recognizing that it is difficult to navigate through the many external resources dealing with drug development, the book has been written to guide the reader towards the most appropriate information sources, including those listed in the two appendices. The following topics are covered: Different types of drugs: from small molecules to stem cells Background to chemistry of small and large molecules Historical background to drug discovery, pharmacology and biotechnology The drug discovery pipeline: from target discovery to marketed medicine Commercial aspects of drug discovery Challenges to the biopharmaceutical industry and its responses Material of specific interest to technology transfer executives, recruiters and pharmaceutical translators   About the Author Dr. Edward D. Zanders has over twenty years’ experience as a scientist and research manager in both a major pharmaceutical company and in smaller biotechnology organizations. He has been responsible for a number of drug discovery programs for diseases such as asthma and rheumatoid arthritis and has been involved in research management at a senior level. He has also published extensively on subjects ranging from biochemistry and immunology to computer-aided drug design; more recently he has written about the application of online networking to drug discovery. In 2004 he founded PharmaGuide Ltd, a training and consultancy company that delivers courses on the drug discovery industry to various professional groups including technology transfer executives, recruiters and technical translators. It is through delivering these courses that he has been able to develop his own way of conveying complex information about drug discovery to non scientists, while at the same time being able to communicate with PhD level scientists at their level of expertise.

Health Care Sector. --- Medical care -- Economic aspects. --- Regenerative medicine -- Economic aspects. --- Regenerative Medicine. --- Tissue engineering -- Economic aspects. --- Drug development --- Pharmaceutical industry --- Investigative Techniques --- Chemistry, Pharmaceutical --- Pharmacology --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Chemistry --- Natural Science Disciplines --- Biological Science Disciplines --- Disciplines and Occupations --- Drug Discovery --- Health & Biological Sciences --- Business & Economics --- Pharmacy, Therapeutics, & Pharmacology --- Industries --- Drug industry --- Drug trade --- Development of drugs --- Drugs --- New drug development --- Development --- Medicine. --- Pharmacology. --- Biomedicine. --- Pharmacology/Toxicology. --- Biomedicine general. --- Medicine industry --- Medicines industry --- Prescription medicine industry --- Chemical industry --- Pharmacy --- Toxicology. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Chemicals --- Medicine --- Poisoning --- Poisons --- Toxicology --- Health Workforce --- Biomedicine, general. --- Drug effects --- Medical pharmacology --- Chemotherapy --- Physiological effect

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Health care should be provided efficiently, given the potential gains for patients and the population and the high cost of some kinds of care. Emphasizing the most cost-effective services can in principle attain the greatest health gains. Policies are implemented through tools available to policy makers, particularly those in government who can influence not only public expenditure and service delivery but also how private insurers and providers allocate resources among diseases and individuals. Example's of tools that nudge a health system toward greater value for money, while respecting fairness and the wishes of taxpayers, patients and health workers, include specifying coverage by insurance or public provision, promoting or limiting medical procedures, and methods of contracting for service delivery and paying providers. Policy Tools reviews an enormous research literature for evidence that particular policies can improve how efficiently health services are delivered, aiming not only at what policies to recommend but at what it takes to make them effective.

Bewijsgebaseerde geneeskunde --- EBM (Medicine) --- Economics [Medical ] --- Economie médicale --- Etat et médicine --- Evidence-based healthcare --- Evidence-based medicine --- Evidenzbasierte Medizin --- Geneeskunde en staat --- Geneeskunde op basis van bewijs --- Geneeskunde--Economische aspecten --- Geneeskunde--Overheidsbeleid --- Geneeskunde--Regeringspolitiek --- Gezondheid--Economische aspecten --- Gezondheidsbeleid --- Gezondheidseconomie --- Gezondheidszorg--Economische aspecten --- Gezondheidszorg--Overheidsbeleid --- Gezondheidszorg--Regeringspolitiek --- Health economics --- Health policy --- Health--Economic aspects --- Hygiene--Economic aspects --- Hygiène--Aspects économiques --- Hygiëne--Economische aspecten --- Medical care--Economic aspects --- Medical care--Government policy --- Medical economics --- Medical policy --- Medicina basada en la evidencia --- Medicina basata su prove di efficacia --- Medicine and state --- Medicine--Economic aspects --- Médecine basée sur des preuves --- Médecine basée sur la preuve --- Médecine basée sur le niveau de preuve --- Médecine basée sur les preuves --- Médecine factuelle --- Médecine fondée sur des preuves --- Médecine fondée sur les données probantes --- Médecine fondée sur les faits --- Médecine--Aspects économiques --- Médecine--Politique gouvernementale --- Médicine et état --- Policy [Medical ] --- Politique de santé --- Politique médicale --- Politique sanitaire --- Protection sanitaire --- Public health--Government policy --- Santé [Politique de ] --- Santé publique--Politique gouvernementale --- Santé--Aspects économiques --- Soins médicaux--Aspects économiques --- Soins médicaux--Politique gouvernementale --- Staat en geneeskunde --- State and medicine --- Medical policy. --- Medical economics. --- Evidence-based medicine. --- Economics, Medical --- Health --- Hygiene --- Medical care --- Medicine --- Health care policy --- Policy, Medical --- Public health --- Public health policy --- Economic aspects --- Government policy --- Science and state --- Social policy --- Clinical medicine --- Systematic reviews (Medical research) --- Decision making --- Health planning --- Methods --- Health care rationing